姚丽君博士长期从事神经精神性疾病相关研究。博士期间在德国马普生物物理化学研究所 Erwin Neher 教授(1991年诺贝尔生理学或医学奖获得者)实验室从事突触可塑性的研究;博士后在美国杜克大学 James McNamara 教授实验室研究癫痫的发生机制。已发表SCI论文十余篇,其中在PNAS、Epilepsy & Behavior、Frontiers in Neurology、Journal of Neurophysiology 和 Frontiers in Psychiatry 等专业期刊发表第一作者/通讯作者论文多篇。目前主要运用人工智能技术开展医学大数据方面的研究,该研究工作得到了上海市卫健委及多个国家/省部级重点实验室支持。
代表性论文:
1.Lijun Yao, Xudong Zhao, Zhiwei Xu, Yang Chen, Liang Liu, Qiang Feng, Fazhan Chen. Influencing factors and machine learning-based prediction of side effects in psychotherapy. Frontiers in Psychiatry, 2020, 11:537442.
2.Yi Guo, Yushan Liu, Wenjie Ming, Zhongjin Wang, Junming Zhu, Yang Chen, Lijun Yao∗, Meiping Ding, Chunhong Shen∗. Distinguishing focal cortical dysplasia from glioneuronal tumors in patients with epilepsy by machine learning. Frontiers in Neurology. 2020, 11:548305. (∗共通讯)
3.Lijun Yao∗, Mengting Cai, Yang Chen, Chunhong Shen, Lei Shi, Yi Guo∗. Prediction of antiepileptic drug treatment outcomes of newly diagnosed epileptic patients by machine learning. Epilepsy & Behavior. 2019, 96:92-97. (∗共通讯)
4.Lijun Yao, Takeshi Sakaba. Activity-dependent modulation of endocytosis by calmodulin at a large central synapse. Proceedings of the National Academy of Sciences. 2012, 109 (1): 291-296.
5.Lijun Yao, Takeshi Sakaba. cAMP modulates intracellular Ca2+ sensitivity of fast-releasing synaptic vesicles at the calyx of Held synapse. Journal of Neurophysiology. 2010, 104(6): 3250-3260.