主持课题：
1.国家自然科学基金面上项目， Nrf2通过SPNS1调控溶酶体功能改善老年肌少症的作用及机制研究，82371586，2024-01至2027-12，49万元，在研，主持。
2.国家自然科学基金面上项目，Nrf2调控OMA1-OPA1通路影响线粒体动力学改善老年肌少症的机制研究，82171565，2022-01至2025-12，55万元，在研，主持。
3.国家自然科学基金青年项目，Nrf2调控FoxO1信号通路改善术后骨骼肌功能的机制研究，81800795，21万，2019.1-2021.12，结题，主持。
4.引进人才（优秀青年）科研启动经费，20万，2018/05-不过期。
荣誉获奖：
1.全国肿瘤营养先进个人 中国抗癌协会肿瘤营养专业委员会，2022
2.北京医学科技奖，北京医学会，一等奖，2021
3.国际NOSES手术视频大赛，中国医师协会结直肠肿瘤专委会，亚军，2020
4.加速康复外科病例演讲点评交流赛全国总决赛，中华普通外科杂志，三等奖，2018
5.全国肿瘤营养菁莪奖 中国抗癌协会肿瘤营养专业委员会，2021
6.全国肿瘤营养新苗奖 中国抗癌协会肿瘤营养专业委员会，2020
7.全国肿瘤营养新苗奖 中国抗癌协会肿瘤营养专业委员会，2019
8.人参联合营养支持改善术后疲劳综合征的基础与临床研究，上海市中医药学会，二等奖 2016，排名第2
9.肠外肠内营养支持治疗的基础研究及临床应用，浙江省人民政府，二等奖，2013，排名第9
10.第八届上海市肠外肠内营养学术年会“青年演讲比赛”，上海市医学会 二等奖，2017
11.中华医学会第十三届全国肠外肠内营养学学术会议大会优秀论文，中华医学会肠外肠内营养学分会，二等奖，2019
12.中华医学会第十三届全国肠外肠内营养学学术会议大会优秀论文，中华医学会肠外肠内营养学分会，三等奖，2019
13.第十届全国肿瘤营养大会优秀论文，中国抗癌协会肿瘤营养专业委员会，二等奖，2021
近五年发表的代表性论著：
1.Zhang FM, Wu HF, Shi HP, Yu Z, Zhuang CL. Sarcopenia and malignancies: epidemiology, clinical classification and implications. Ageing Res Rev. 2023 Sep 2;91:102057. doi: 10.1016/j.arr.2023.102057. Epub ahead of print. PMID: 37666432.(IF:13.1)，通讯作者
2.Zhuang CL, Zhang FM, Li W, Wang KH, Xu HX, Song CH, Guo ZQ, Shi HP. Associations of low handgrip strength with cancer mortality: a multicentre observational study. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1476-1486. (IF:12.9)，第一作者
3.Zhang FM, Wu HF, Wang KF, Yu DY, Zhang XZ, Ren Q, Chen WZ, Lin F, Yu Z, Zhuang CL. Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity. Cell Death Dis. 2024 Jun 28;15(6):459.(IF:8.1)，通讯作者
4.Zhang X, Zhang F, Wu H, Yu Z, Zhuang C. SPNS1 ablation drives skeletal muscle atrophy by disrupting mitophagy, mitochondrial function, and apoptosis in mice. Genes Dis. 2023 Sep 7;11(5):101083. (IF:6.9)，通讯作者
5.Liu L, He J, Sun G, et al. The N6-methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma. Clin Transl Med. 2022;12(5):e778. (IF: 10.6)，共同通讯作者
6.Cai Y, Song W, Li J，et al. The landscape of aging. Sci China Life Sci. 2022 Dec;65(12):2354-2454. (IF:9.1)，共同第一作者
7.Zhang FM, Zhuang CL, Dong QT, Yu Z, Cheng J, Shen X, Wang SL. Characteristics and prognostic impact of cancer cachexia defined by the Asian Working Group for Cachexia consensus in patients with curable gastric cancer. Clin Nutr. 2024 Jun;43(6):1524-1531.(IF:6.6)，共同第一作者
8.Zhang FM, Zhuang CL, Dong QT, et al. Characteristics and prognostic impact of cancer cachexia defined by the Asian Working Group for Cachexia consensus in patients with curable gastric cancer. Clin Nutr. 2024 May 10;43(6):1524-1531. (IF:6.3)，共同第一作者
9.Wang SL, Zhang FM, Chen CB, et al. Comparison between AWGC-cachexia and GLIM-malnutrition in patients with gastric cancer. European Journal of Surgical Oncology.(IF:3.5)，通讯作者
10.Zhuang CL, Wu HF al.Metabolomic analysis of circulating tumor cells derived liver metastasis of colorectal cancer. Heliyon.Nutrition. (IF:4.4)，第一作者
11.Wu HF, Yan JP, Wu Q, Yu Z, Xu HX, Song CH, Guo ZQ, Li W, Xiang YJ, Xu Z, Luo J, Cheng SQ, Zhang FM, Shi HP, Zhuang CL; Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group. Discovery of distinct cancer cachexia phenotypes using an unsupervised machine-learning algorithm. Nutrition. 2023 Nov 29;119:112317. (IF:4.4)，通讯作者
12.Zhang FM, Song CH, Guo ZQ, Yu Z, Weng M, Zhou FX, Liu M, Cong MH, Li T, Li ZN, Chen JQ, Cui JW, Xu HX, Li W, Shi HP, Zhuang CL; Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group. Sarcopenia prevalence in patients with cancer and association with adverse prognosis: A nationwide survey on common cancers. Nutrition. 2023 Oct;114:112107.(IF:4.4)，通讯作者
13.Chen WZ, Zhang XZ, Zhang FM, Yu DY, Chen WH, Lin F, Dong QT, Zhuang CL, Yu Z. Coexistence of GLIM-defined malnutrition and sarcopenia have negative effect on the clinical outcomes in the elderly gastric cancer patients after radical gastrectomy. Front Nutr. 2022 Aug 19;9:960670. doi: 10.3389/fnut.2022.960670. PMID: 36061885; PMCID: PMC9437552.(IF:5.0)，共同通讯作者
14.Zhuang CL, Zhang FM, Xu HX, et al. Reference values of low body mass index, mid-upper arm circumference, and calf circumference in cancer patients: A nationwide multicenter observational study Nutrition. 2022;99-100:111688. (IF: 4.4)，第一作者
15.Zhuang CL, Dong QT, Shi HP, et al. Cachexia Versus Sarcopenia in Clinical Characteristics and Prognostic Value After Radical Gastrectomy for Gastric Cancer: A Large-Scale Prospective Study. Ann Surg Oncol. 2022;29(4):2348-2358. (IF: 3.7)，第一作者
16.Zhang FM, Zhang XZ, Zhu GL, Lv LQ, Yan XL, Wu WX, Wang SL, Chen XL, Zhuang CL, Yu Z. Impact of sarcopenia on clinical outcomes of patients with stage I gastric cancer after radical gastrectomy: A prospective cohort study [published online ahead of print, 2021 Aug 17]. Eur J Surg Oncol. 2021;S0748-7983(21)00693-4. doi:10.1016/j.ejso.2021.08.021 (IF:3.8)，共同通讯作者
17.Zhang FM, Zhang XZ, Shi HP, Zhang Z, Wang SL, Shen ZL, Chen XL, Shen X, Yu Z, Zhuang CL. Comparisons and Impacts of the Basic Components of Sarcopenia Definition and Their Pairwise Combinations in Gastric Cancer: A Large-Scale Study in a Chinese Population. Front Nutr. 2021;8:709211. Published 2021 Oct 20. doi:10.3389/fnut.2021.709211 (IF:5.0) ，通讯作者
18.Zhuang CL, Zhang FM, Wang Z, Jiang X, Wang F, Liu ZC. Precision functional sphincter-preserving surgery (PPS) for ultralow rectal cancer: a natural orifice specimen extraction (NOSE) surgery technique. Surg Endosc. 2021 Jan;35(1):476-485. doi: 10.1007/s00464-020-07989-4. Epub 2020 Sep 28. PMID: 32989539，(IF: 3.1)，第一作者
19.Zhang FM, Chen XL, Wu Q, Dong WX, Dong QT, Shen X, Shi HP, Yu Z, Zhuang CL. Development and validation of nomograms for the prediction of low muscle mass and radiodensity in gastric cancer patients. Am J Clin Nutr. 2021 Feb 2;113(2):348-358. doi: 10.1093/ajcn/nqaa305. PMID: 33300037. (IF:7.1)，通讯作者
20.Zou HB, Yan XL, Dong WX, Yu DY, Zhang FM, Zhou LP, Shen ZL, Cai GJ, Zhuang CL, Yu Z. Sarcopenia is a predictive factor of poor quality of life and prognosis in patients after radical gastrectomy. Eur J Surg Oncol. 2021 Aug;47(8):1976-1984. doi: 10.1016/j.ejso.2021.03.004. Epub 2021 Mar 6. PMID: 33714648. (IF:3.8)，共同通讯作者
21.Zhang F. M., Ma B.W., Huang Y. Y., Chen W. Z., Chen J. J., Dong Q. T., Chen W. S., Chen X.L., Shen X., Yu Z., Zhuang C.L., Laparoscopic colorectal cancer surgery reduces the adverse impacts of sarcopenia on postoperative outcomes: A propensity score-matched analysis. Surgical Endoscopy. 2020 Oct;34(10):4582-4592. Epub 2019 Nov 18. (IF:3.1)，通讯作者
22.Zhuang C. L., Shen X., Huang Y. Y., Zhang F. M., Chen X. Y., Ma L. L., Chen X. L., Yu Z., Wang S. L. Myosteatosis predicts prognosis after radical gastrectomy for gastric cancer: A propensity score-matched analysis from a large-scale cohort. Surgery. 2019,166(3):297-304. (IF:3.8)，第一作者
23.Chen X.Y., Zhang X.Z., Ma B.W., Li B., Zhou D.L., Liu Z.C., Chen X.L., Shen X., Yu Z., Zhuang C.L., A comparison of four common malnutrition risk screening tools for detecting cachexia among patients with curable gastric cancer. Nutrition. 2020 Feb;70:110498. Epub 2019 Apr 26. Doi: org/10.1016/j.nut.2019.04.009 (IF: 4.4)，通讯作者
24.Zhou LP, Yu DY, Ma BW, Shen ZL, Zou HB, Zhang XZ, Yan XL, Zhuang CL, Yu Z. Feasibility of substituting handgrip strength for muscle mass as a constituent standard in the Global Leadership Initiative on Malnutrition for diagnosing malnutrition in patients with gastrointestinal cancers. Nutrition. 2020 Oct 30;84:111044. doi: 10.1016/j.nut.2020.111044. Epub ahead of print. PMID: 33517155. (IF: 4.4)，共同通讯作者
25.Ma B. W., Chen X. Y., Fan S. D., Zhang F. M., Huang D. D., Li B., Shen X., Zhuang C. L., Yu Z. Impact of sarcopenia on clinical outcomes after radical gastrectomy for patients without nutritional risk. Nutrition. 2019,6161-66. (IF: 4.4)，共同通讯作者
26.Huang D. D., Fan S. D., Chen X. Y., Yan X. L., Zhang X. Z., Ma B. W., Yu D. Y., Xiao W. Y., Zhuang C. L., Yu Z. Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner. Experimental gerontology. 2019,11961-73. (IF: 3.9)，共同通讯作者
27.Chen X. Y., Li B., Ma B. W., Zhang X. Z., Chen W. Z., Lu L. S., Shen X., Zhuang C. L., Yu Z. Sarcopenia is an effective prognostic indicator of postoperative outcomes in laparoscopic-assisted gastrectomy. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2019. (IF: 3.8)，共同通讯作者
28.Zhuang C. L., Shen X., Zou H. B., Dong Q. T., Cai H. Y., Chen X. L., Yu Z., Wang S. L., EWGSOP2 Versus EWGSOP1 for sarcopenia to predict prognosis in patients with gastric cancer after radical gastrectomy: analysis from a large-scale prospective study. Clin Nutr. 2020 Jul;39(7):2301-2310. Doi: org/ /10.1016/j.clnu.2019.10.024 (IF:6.3)，第一作者
发明专利：
1.庄成乐等，一种专用于大鼠腹腔注射的设备，国家发明专利，ZL201310598852.0（第一发明人）
2.章晓东;沈贤;庄成乐;一种负压双套引流管,2022-06-24,中国,CN201610389057.4
3.张现中；张锋敏；余鼎业；马兵伟；庄成乐；余震；一种用于动物医学实验的解剖装置，国家发明专利，ZL2021 1 1041561.2
