脓毒症与脓毒症脏器损伤的分子机制与临床干预研究，脓毒症队列的建立与机器学习预测模型的建立；心肺脑复苏预后预测模型研究；肠菌移植在重症感染患者中应用的基础与临床研究。

Researching the molecular mechanisms and clinical interventions of sepsis and sepsis induced organ injury, establishing a sepsis cohort, and developing a machine learning prediction model. Studying prognostic prediction models for cardiopulmonary and cerebral resuscitation. Basic and clinical researching on fecal microbiota transplantation in patients with severe infections.

院内任职：急诊医学科行政副主任，急诊感染党支部副书记

社会学术任职：

1) 上海市医师协会急诊科医师分会委员 2025/08-2028/08

2) 上海市医学会急诊医学分会青年委员会秘书 2024/02-2027/02

3) 上海市中西医结合学会急救医学专委会委员 2023/02-2026/02

4) 中国中西医结合学会急救医学专业委员会青年委员 2022/11-2025/11

5) 中国医疗保健国际交流促进会急诊分会委员 2021/11-2025/11

6) 上海市中医药学会危重病分会青年委员 2019/01-2023/01

Position in hospital:

Deputy Director of Emergency Medicine Department, Deputy Secretary of the Emergency Infection Party Branch

Social and Academic positions:

1) Member of the Emergency Physicians Branch of the Shanghai Medical Doctor Association 08/2025-08/2028

2) Secretary of Youth Committee, Emergency Medicine Branch of Shanghai Medical Association 02/2024-02/2027

3) Member of the Emergency Medicine Committee of Shanghai Association of Chinese Integrated Medicine 02/2023-02/2026

4) Youth member of Emergency Medicine Professional Committee of Chinese Association of Integrated Medicine 11/2022-11/2025

5) Member of the Emergency Branch of China Association International Exchange and Promotive for Medical and Health Care 11/2021-11/2025

6) Youth Member of Critical Care Branch of Shanghai Association of Chinese Medicine 01/2019-01/2023

针对脓毒症肺损伤进行了系列基础和临床研究，在脓毒症内皮损伤机制方面提出了新颖的机制；在心肺脑复苏方面开展系列动物和临床研究，对心肺复苏预后的影响因素和心肺复苏预后预测生物标志物方面提出了较为新颖的观点；针对肠菌移植在重症感染患者中的应用展开了系列研究。近几年主要相关科研成果如下：

一、期刊论文（“#”为共同第一作者，“*”为通讯作者）：

1. Zhao J#, Lin ST#, Qin AH#, Zhou CR#, Huang XD, Chen HG, Zhou SQ*, Peng H*, Chen YZ*,. Impact of diastolic blood pressure time under range on mortality and acute kidney injury in septic patients: a retrospective cohort study. BMC Anesthesiol. 2025 Oct 21;25(1):512.

2. Zhao J#, Huang D#, Hua S#, Huang X, Chen Y*, Zhuang Y*. Time in targeted blood glucose range as an independent predictor of 28-Day mortality in ICU Patients: A retrospective study. Diabetes Res Clin Pract. 2025 Mar;221:112033.

3. Zhao J#, Dai R#, Zhao Y#, Tan J#, Hao D, Ren J, Wang X, Chen Y, Peng H, Zhuang Y, Zhou S*, Chen Y*. Immune Subtypes in Sepsis: A Retrospective Cohort Study Utilizing Clustering Methodology. J Inflamm Res. 2024 Dec 28;17:11719-11728.

4. Zhao J#, Jiang HH#, Wan HH#, Liu D#, Zhao Y#, Chen YQ*, Chen YZ*. The impact of dexamethasone on short- and long-term mortality in hospitalized COVID-19 patients: a retrospective study. BMC Infect Dis. 2024 Nov 25;24(1):1343.

5. Si H#, Chen Y#, Jiang K, Ma K, Ramsey E, Oakey J*, Sun M*, Jiang Z*: Deterministic Single-Cell Encapsulation in PEG Norbornene Microgels for Promoting Anti-Inflammatory Response and Therapeutic Delivery of Mesenchymal Stromal Cells. Adv Healthc Mater 2024, 13(14):e2304386.

6. Zhao J#, Zhou SQ#, Chen YX#, Pan X, Chen YZ*, Zhuang YG*: Causal Relationship between Mitochondrial-Associated Proteins and Sepsis in ICU Patients: A Mendelian Randomization Study. ACS Omega 2024, 9(7):8457-8463.

7. Liu D#, Zhao J#, Xia H, Dong S, Yan S, Zhuang Y, Chen Y*, Peng H*: Nafamostat mesylate versus regional citrate anticoagulation for continuous renal replacement therapy in patients at high risk of bleeding: a retrospective single-center study. Eur J Med Res 2024, 29(1):72.

8. Chen Y#, Zhao J#, Ye H#, Ceylan-Isik AF, Zhang B, Liu Q, Yang Y, Dong M, Luo B*, Ren J*: Beneficial impact of cardiac heavy metal scavenger metallothionein in sepsis-provoked cardiac anomalies dependent upon regulation of endoplasmic reticulum stress and ferroptosis but not autophagy. Life sciences 2024, 336:122291.

9. Zhao J#, Dai RS#, Chen YZ*, Zhuang YG*: Prognostic significance of lymphocyte subpopulations for ICU-acquired infections in patients with sepsis: a retrospective study. J Hosp Infect 2023, 140:40-45.

10. Chen Y#, Liu D#, Li X, Nie K, Yan S, Peng H, Zhuang Y*, Sun M*: Aggressive alternative splicing events discovered in cecum ligation and puncture induced lung injury. Biochemical and biophysical research communications 2023, 655:90-96.

11. Chen YZ, Zhou SQ, Chen YQ, Peng H*, Zhuang YG*: Plasma Adipokines in Patients Resuscitated from Cardiac Arrest: Difference of Visfatin between Survivors and Nonsurvivors. Dis Markers 2020, 2020:9608276.

12. Chen J#, Wang H#, Gao C, Liu D, Fan Y, Li W, Chen Y*, Pan S*: Tetramethylpyrazine alleviates LPS-induced inflammatory injury in HUVECs by inhibiting Rho/ROCK pathway. Biochemical and biophysical research communications 2019, 514(1):329-335.

13. Chen Y#, Peng H#, Zhou S, Zhuang Y*: ADAR1 is targeted by miR-143 to regulate IL-1beta-induced endothelial activation through the NFkappaB pathway. Int J Biochem Cell Biol 2017, 89:25-33.

14. Chen Y#, Jiang B#, Zhuang Y, Peng H, Chen W*: Differential effects of heat shock protein 90 and serine 1179 phosphorylation on endothelial nitric oxide synthase activity and on its cofactors. PloS one 2017, 12(6):e0179978.

15. Wang H#, Chen Y#, Li W, Li C, Zhang X, Peng H*, Gao C*: Ligustrazine effect on lipopolysaccharide-induced pulmonary damage in rats. Burns : journal of the International Society for Burn Injuries 2015, 41(6):1235-1241.

16. Chen YZ, Yan SY, Chen YQ, Zhuang YG, Wei Z, Zhou SQ, Peng H*: Noninvasive monitoring of intra-abdominal pressure by measuring abdominal wall tension. World J Emerg Med 2015, 6(2):137-141.

17. Zhuang Y#, Li W#, Wang H, Peng H, Chen Y, Zhang X, Chen Y*, Gao C*: Predicting the Outcomes of Subjects With Severe Community-Acquired Pneumonia Using Monocyte Human Leukocyte Antigen-DR. Respir Care 2015, 60(11):1635-1642.

18. Chen S#, Li W#, Zhang Z#, Min H, Li H, Wang H, Zhuang Y, Chen Y*, Gao C, Peng H*: Evaluating the Quality of Cardiopulmonary Resuscitation in the Emergency Department by Real-Time Video Recording System. PloS one 2015, 10(10):e0139825.

19. Chen YZ, Xu YF, Zheng JH*: Effect of carbon dioxide pneumoperitoneum on human renal cell carcinoma proliferation and metastasis in an orthotropic xenograft nude mouse model. Archives of medical science : AMS 2014, 10(5):1041-1046.

20. Zhang C#, Chen Y#, Wang M, Chen X, Li Y, Song E, Liu X, Kim S*, Peng H*: PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cells. World J Surg Oncol 2014, 12:258.

21. 陈远卓, 严姝瑛, 陈艳清, 庄育刚, 赵伟, 周书琴, 彭沪*: 通过测量腹壁张力无创监测腹内压的临床研究. 中华急诊医学杂志 2014, 23(4):421-425.

二、科研课题：

1. 国家自然科学基金面上项目，82572470，NCBP2介导ATG16L1可变剪切调控线粒体自噬减轻脓毒症肺损伤的作用与机制，2026/01-2019/12，49万，在研，主持。

2. 睿E（睿意）急诊医学研究专项基金，22222012008，粪菌移植应用于危重症患者抗生素相关性腹泻治疗的临床研究，单中心，2022/10-2024/09，3万，在研，主持。

3. 中央高校基本科研业务费专项资金，22120180391，内皮细胞Caspase-11依赖的焦亡炎症通路在脓毒症急性肺损伤中的作用及机制，2018/09-2019/08，5万，已结题，主持。

4. 国家自然科学基金青年项目，81501696，ADAR1调控Caveolin-1对肺微血管内皮细胞通透性的影响及机制研究，2016/01-2018/12，21.6万，已结题，主持。

5. 国家自然科学基金面上项目，81971804，TNIP2通过负向调控TNF-α信号通路减轻心肺复苏脑损伤的作用及机制研究，2020/01-2023/12，66万，已结题，第一参与人。

6. 国家自然科学基金面上项目，81870011，粘合蛋白β4 表达调节机理在急性肺损伤中的作用，2019/01-2022/12，68.4万，已结题，第三参与人。

7. 上海市卫计委面上项目，201740240，经鼻高流量呼吸治疗（HFNC）在慢性呼吸功能不全患者中的应用研究，2018/01-2020/12，10万，已结题，第二参与人。

8. 国家自然科学基金面上项目，81671938，ADAR1调控Caspase-11非经典炎症小体激活在脓毒症急性肺损伤中的作用及机制，2017/01-2020/12，69.6万，已结题，第二参与人。

9. 国家自然科学基金面上项目，81270133，辛伐斯坦通过claudin-5蛋白调节内皮细胞屏障功能，2013/01-2016/12，70万，已结题，主要参与人。

10. 上海市卫生局项目，2012J011A，从Rock/MLCK信号通路研究川芎嗪对内皮微粒的生成及内皮细胞通透性的作用机制，2013/01-2016/12，2万，已结题，主要参与人。

11. 国家自然科学基金青年项目，81000024，内皮微粒介导的Rock/MLCK通路的激活对肺微血管内皮细胞通透性的影响，2011/01-2013/12，20万，已结题，主要参与人。

12. 上海市科委项目，11QA1405100，内毒素激活Rho信号调节肺微血管内皮细胞通透性及内皮微粒在此过程中的作用机制，2011/04-2013/03，15万，已结题，主要参与人。

13. 上海市卫生局项目，2009143，ALI/ARDS患者机械通气时最佳PEEP值的临床研究，2010/01-2013/01，4万，已结题，主要参与人。

三、急诊重症相关论著：

1. 新机械通气手册，新世界图书出版公司，2020年，副主编

2. 胰腺整合介入治疗学（中英文版），同济大学出版社，2019年，参编（获第五届中国政府出版奖）

3. 重症监护（消化系统监护部分），郑州大学出版社，2013年，参编

四、授权发明专利：(针对动物实验过程中的问题发明的实验改良装置)

1. 陈远卓，一种带磁力扣固定装置的小鼠手术台，2017年，中国，ZL201620955686.4

五、牵头注册并建立全国多中心脓毒症队列研究（CHiCTR2200067084）

Basic and Clinical Studies on Sepsis-Induced Lung Injury

I have conducted a series of studies on the mechanisms and treatments of sepsis-induced lung injury, including basic research on novel molecular mechanisms of sepsis-related endothelial injury and clinical investigations into the predictors of prognosis and biomarkers in cardiopulmonary resuscitation (CPR). Additionally, I have led multiple studies exploring the application of fecal microbiota transplantation (FMT) in critically ill patients. Below is a summary of my recent research achievements.

1. Journal Publications(# indicates co-first author, * indicates corresponding author)

1) Zhao J#, Lin ST#, Qin AH#, Zhou CR#, Huang XD, Chen HG, Zhou SQ*, Peng H*, Chen YZ*,. Impact of diastolic blood pressure time under range on mortality and acute kidney injury in septic patients: a retrospective cohort study. BMC Anesthesiol. 2025 Oct 21;25(1):512.

2) Zhao J#, Huang D#, Hua S#, Huang X, Chen Y*, Zhuang Y*. Time in targeted blood glucose range as an independent predictor of 28-Day mortality in ICU Patients: A retrospective study. Diabetes Res Clin Pract. 2025 Mar;221:112033.

3) Zhao J#, Dai R#, Zhao Y#, Tan J#, Hao D, Ren J, Wang X, Chen Y, Peng H, Zhuang Y, Zhou S*, Chen Y*. Immune Subtypes in Sepsis: A Retrospective Cohort Study Utilizing Clustering Methodology. J Inflamm Res. 2024 Dec 28;17:11719-11728.

4). Zhao J#, Jiang HH#, Wan HH#, Liu D#, Zhao Y#, Chen YQ*, Chen YZ*. The impact of dexamethasone on short- and long-term mortality in hospitalized COVID-19 patients: a retrospective study. BMC Infect Dis. 2024 Nov 25;24(1):1343.

5) Si H#, Chen Y#, Jiang K, Ma K, Ramsey E, Oakey J*, Sun M*, Jiang Z*: Deterministic Single-Cell Encapsulation in PEG Norbornene Microgels for Promoting Anti-Inflammatory Response and Therapeutic Delivery of Mesenchymal Stromal Cells. Adv Healthc Mater 2024, 13(14):e2304386.

6) Zhao J#, Zhou SQ#, Chen YX#, Pan X, Chen YZ*, Zhuang YG*: Causal Relationship between Mitochondrial-Associated Proteins and Sepsis in ICU Patients: A Mendelian Randomization Study. ACS Omega 2024, 9(7):8457-8463.

7) Liu D#, Zhao J#, Xia H, Dong S, Yan S, Zhuang Y, Chen Y*, Peng H*: Nafamostat mesylate versus regional citrate anticoagulation for continuous renal replacement therapy in patients at high risk of bleeding: a retrospective single-center study. Eur J Med Res 2024, 29(1):72.

8) Chen Y#, Zhao J#, Ye H#, Ceylan-Isik AF, Zhang B, Liu Q, Yang Y, Dong M, Luo B*, Ren J*: Beneficial impact of cardiac heavy metal scavenger metallothionein in sepsis-provoked cardiac anomalies dependent upon regulation of endoplasmic reticulum stress and ferroptosis but not autophagy. Life sciences 2024, 336:122291.

9) Zhao J#, Dai RS#, Chen YZ*, Zhuang YG*: Prognostic significance of lymphocyte subpopulations for ICU-acquired infections in patients with sepsis: a retrospective study. J Hosp Infect 2023, 140:40-45.

10) Chen Y#, Liu D#, Li X, Nie K, Yan S, Peng H, Zhuang Y*, Sun M*: Aggressive alternative splicing events discovered in cecum ligation and puncture induced lung injury. Biochemical and biophysical research communications 2023, 655:90-96.

11) Chen YZ, Zhou SQ, Chen YQ, Peng H*, Zhuang YG*: Plasma Adipokines in Patients Resuscitated from Cardiac Arrest: Difference of Visfatin between Survivors and Nonsurvivors. Dis Markers 2020, 2020:9608276.

12) Chen J#, Wang H#, Gao C, Liu D, Fan Y, Li W, Chen Y*, Pan S*: Tetramethylpyrazine alleviates LPS-induced inflammatory injury in HUVECs by inhibiting Rho/ROCK pathway. Biochemical and biophysical research communications 2019, 514(1):329-335.

13) Chen Y#, Peng H#, Zhou S, Zhuang Y*: ADAR1 is targeted by miR-143 to regulate IL-1beta-induced endothelial activation through the NFkappaB pathway. Int J Biochem Cell Biol 2017, 89:25-33.

14) Chen Y#, Jiang B#, Zhuang Y, Peng H, Chen W*: Differential effects of heat shock protein 90 and serine 1179 phosphorylation on endothelial nitric oxide synthase activity and on its cofactors. PloS one 2017, 12(6):e0179978.

15) Wang H#, Chen Y#, Li W, Li C, Zhang X, Peng H*, Gao C*: Ligustrazine effect on lipopolysaccharide-induced pulmonary damage in rats. Burns : journal of the International Society for Burn Injuries 2015, 41(6):1235-1241.

16) Chen YZ, Yan SY, Chen YQ, Zhuang YG, Wei Z, Zhou SQ, Peng H*: Noninvasive monitoring of intra-abdominal pressure by measuring abdominal wall tension. World J Emerg Med 2015, 6(2):137-141.

17) Zhuang Y#, Li W#, Wang H, Peng H, Chen Y, Zhang X, Chen Y*, Gao C*: Predicting the Outcomes of Subjects With Severe Community-Acquired Pneumonia Using Monocyte Human Leukocyte Antigen-DR. Respir Care 2015, 60(11):1635-1642.

18) Chen S#, Li W#, Zhang Z#, Min H, Li H, Wang H, Zhuang Y, Chen Y*, Gao C, Peng H*: Evaluating the Quality of Cardiopulmonary Resuscitation in the Emergency Department by Real-Time Video Recording System. PloS one 2015, 10(10):e0139825.

19) Chen YZ, Xu YF, Zheng JH*: Effect of carbon dioxide pneumoperitoneum on human renal cell carcinoma proliferation and metastasis in an orthotropic xenograft nude mouse model. Archives of medical science : AMS 2014, 10(5):1041-1046.

20) Zhang C#, Chen Y#, Wang M, Chen X, Li Y, Song E, Liu X, Kim S*, Peng H*: PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cells. World J Surg Oncol 2014, 12:258.

21) Chen Yuanzhuo, Yan Shuying, Chen Yanqing, Zhuang Yufeng, Zhao Wei, Zhou Shuqin, Peng Hu*. Clinical study on non-invasive monitoring of intra-abdominal pressure by measuring abdominal wall tension. Chinese Journal of Emergency Medicine. 2014;23(4):421-425.

2. Research Grants

1) National Natural Science Foundation of China (NSFC) General Project, Grant No. 82572470, Mechanisms of NCBP2-Mediated ATG16L1 Alternative Splicing in Regulating Mitophagy to Alleviate Sepsis-Induced Lung Injury, 01/2026/ - 12/2019/, 490,000 RMB, Ongoing, Principal Investigator.

2) Rui E (Ruiyi) Emergency Medicine Research Fund, Grant No. 22222012008, Clinical Study on the Application of Fecal Microbiota Transplantation for Antibiotic-Associated Diarrhea in Critically Ill Patients: A Single-Center Study, 10/2022 – 09/2024/, 30,000 RMB, Ongoing, Principal Investigator.

3) Central University Basic Research Fund, Grant No. 22120180391, Role and Mechanisms of Caspase-11-Dependent Pyroptotic Inflammatory Pathway in Endothelial Cells during Sepsis-Induced Acute Lung Injury, 09/2018/ - 08/2019, 50,000 RMB, Completed, Principal Investigator.

4) NSFC Youth Project, Grant No. 81501696, Regulation of Caveolin-1 by ADAR1 and Its Impact on Pulmonary Microvascular Endothelial Cell Permeability, 01/2016 – 12/2018, 216,000 RMB, Completed, Principal Investigator.

5) NSFC General Project, Grant No. 81971804, Role and Mechanisms of TNIP2 in Attenuating Cardiopulmonary Resuscitation-Induced Brain Injury via Negative Regulation of the TNF-α Signaling Pathway, 01/2020 - 12/2023, 660,000 RMB, Completed, First Co-Investigator.

6) NSFC General Project, Grant No. 81870011, Regulatory Mechanisms of Adhesive Protein β4 Expression in Acute Lung Injury, 01/2019 - 12/2022, 684,000 RMB, Completed, Third Co-Investigator.

7) Shanghai Municipal Health Commission General Project, Grant No. 201740240, Application of High-Flow Nasal Cannula Oxygen Therapy (HFNC) in Patients with Chronic Respiratory Insufficiency, 01/2018 – 12/2020, 100,000 RMB, Completed, Second Co-Investigator.

8) NSFC General Project, Grant No. 81671938, Role and Mechanisms of ADAR1 in Regulating Caspase-11 Non-Canonical Inflammasome Activation in Sepsis-Induced Acute Lung Injury, 01/2017 – 12/2020, 696,000 RMB, Completed, Second Co-Investigator.

9) NSFC General Project, Grant No. 81270133, Regulation of Claudin-5 Protein by Simvastatin and Its Effects on Endothelial Cell Barrier Function, 01/2013 – 12/2016, 700,000 RMB, Completed, Major Participant.

10) Shanghai Municipal Health Bureau Project, Grant No. 2012J011A, Clinical Study on the Optimal PEEP Value during Mechanical Ventilation in ALI/ARDS Patients, 01/2010 – 01/2013, 40,000 RMB, Completed, Major Participant.

11) NSFC Youth Project, Grant No. 81000024, Impact of Endothelial Microparticles Mediated by Rock/MLCK Pathway Activation on Pulmonary Microvascular Endothelial Cell Permeability, 01/2011 – 12/2013, 200,000 RMB, Completed, Major Participant.

12) Shanghai Science and Technology Commission Project, Grant No. 11QA1405100, Regulation of Pulmonary Microvascular Endothelial Cell Permeability and the Role of Endothelial Microparticles in the Process of Endotoxin-Activated Rho Signaling, 04/2011 – 03/2013, 150,000 RMB, Completed, Major Participant.

13) Shanghai Municipal Health Bureau Project, Grant No. 2009143, Clinical Study on Optimal PEEP Values in Mechanically Ventilated ALI/ARDS Patients, 01/2010 - 01/2013, 40,000 RMB, Completed, Major Participant.

3. Textbooks and Monographs

1) New Manual of Mechanical Ventilation (Deputy Chief Editor), Xinshijie Publishing House, 2020.

2) Integrated Interventional Therapy for Pancreas (English-Chinese Edition, Contributor), Tongji University Press, 2019. (Won the 5th Government Publishing Award of China)

3) Critical Care Medicine: Digestive System Monitoring (Contributor), Zhengzhou University Press, 2013.

4. Patents

Chen Yuanzhuo. A mouse surgical platform with magnetic fixation device.

Patent No.: ZL201620955686.4

Year: 2017 (China).

5. Multicenter Cohort Study

Principal Investigator: Established and registered the nationwide multicenter sepsis cohort study (CHiCTR2200067084).