北京大学医学部内科学专业八年制博士,美国UC Davis Medical Center、Texas Heart Institute访问学者。现就职于同济大学附属东方医院心血管内科,专业方向为心电生理,常规从事心律失常导管消融、左心耳封堵、心脏起搏器植入等介入手术,已获国家卫健委心律失常介入治疗资质。致力于心律失常基础及临床研究,主持国家科技重大专项1项、省市级科研项目3项,发表SCI论文20余篇,影响因子60余分,获省级医疗新技术引进奖2项、中华商业联合会科学技术奖1项、市科技进步奖1项,荣获浦东新区卫生英才、浦东新区优秀青年人才、扬州市“绿扬金凤”优秀博士称号。
【科研项目】
(1)经导管主动脉瓣置换术后新发房颤筛查及节律管理策略的临床价值研究,国家科技计划四大慢病重大专项,2023ZD0513700,2024/08-2027/7,60万元,主持;
(2)5-AZA诱导MSC外泌体miRNA3543通过调控Smad3改善心肌纤维化机制研究,江苏省苏北人民医院基础科研专项基金,BHSJJ1802,2018/10—2022/10,10万元,主持;
(3)DNA甲基化及组蛋白修饰对MSC诱导分化为心肌细胞的交互调控机制研究,扬州市“绿扬金凤计划”优秀博士项目,YZLYJFJH2016YB112, 2016/10—2019/10,10万元,主持;
(4)极小胚胎样干细胞跨物种移植治疗急性心肌梗死的安全性和有效性研究,江苏省苏北人民医院博士科研启动基金,KYQDJ1602,2016/08—2020/08,10万元,主持;
(5)基于HCN转染VSELs构建生物起搏信号通路筛选诱导剂,国家自然科学基金面上项目,81370305,2013/01—2017/12,75万元,参与;
(6)专科医生指导下社区医护家庭成员心血管病远程精准管理体系构建与医学循证,江苏省科技计划专项,BL2013022,2013/07—2018/06,200万元,参与。
【主要论文】
(1)Xu L, Wang Z, Sun L, Liu B, Li H. Ultrafiltration in Elderly Patients with Type 1 Cardiorenal Syndrome: Efficacy and Safety Outcomes. Cardiorenal Med. 2025 May 19:1-13. (IF 2.9/Q2,通讯作者)
(2)Li H, Li G, Gao Y, Ma Y, Yu Z, Zhang A, Yang G, Hou Z, Zhang Y, Yu Y, Zhang Z. Oligo-peptide I-C-F-6 mitigates polymicrobial sepsis-induced cardiac dysfunction in mice. Eur J Pharmacol. 2025 Jun 5;996:177545.(IF 4.7/Q1,第一作者)
(3)李红校,黄碧君,王路鑫,等. 经导管主动脉瓣置换术后房性心动过速射频消融1例[J]. 中国介入心脏病学杂志, 2024,32 (04): 232-235.
(4)Hongxiao Li,Jianjun Gu, Xiaolin Sun, Qisheng Zuo, Bichun Li, Xiang Gu. Isolation of Swine Bone Marrow Lin-/CD45-/CD133 + Cells and Cardio-protective Effects of its Exosomes. Stem Cell Rev Rep. 2023,19(1):213-229.(IF 6.692/Q1,第一作者)
(5)Gu JJ, Li HX, Wei W, Sun XL, Li BC, Chen Y, Li J, Gu X. Bone marrow mesenchymal stem cell transplantation alleviates radiation-induced myocardial fibrosis through inhibition of the TGF-β1/Smad2/3 signaling pathway in rabbit model. Regen Ther. 2023,29(24):1-10. (IF 4.3/Q3,共同一作)
(6)Wang Z, Li H, Sun L, Liu B, Gu X. Efficacy and safety of ultrafiltration combined with haemodialysis in patients with uraemia who cannot tolerate dialysis because of hypotension. Acta Cardiol. 2023,10(31):1-6. (IF 1.6/Q4, 共同一作)
(7)Zhen Wang, Chenlu Zhong, Hongxiao Li. Histone demethylase KDM5B catalyzed H3K4me3 demethylation to promote differentiation of bone marrow mesenchymal stem cells into cardiomyocytes. Mol Biol Rep. 2022,49(8):7239-7249.(IF 2.742/Q3,通讯作者)
(8)李红校; 孙磊; 鲍正宇; 陈福坤; 顾翔; 老年急性冠状动脉综合征患者临床诊疗指南依从性现状分析[J]. 中华老年心脑血管病杂志, 2022, 24(1): 51-54. (北大核心, 第一作者)
(9)Luo X, Li H, Sun X, Zuo Q, Li B, Zhu Y, Wei W, Gu X. Promotion of Differentiating Bone Marrow Mesenchymal Stromal Cells (BMSCs) into Cardiomyocytes via HCN2 and HCN4 Cotransfection. Biomed Res Int. 2021,13(8):5529276. (IF 3.246/Q3, 共同作者)
(10)Sun X#, Gu X#, Li H#, Xu P, Li M, Zhu Y, Zuo Q, Li B. H3K9me2 regulates early transcription factors to promote mesenchymal stem‑cell differentiation into cardiomyocytes. Mol Med Rep. 2021,24(2):616. (IF 3.423/Q3, 共同一作)
(11)Jiang J#, Gu X#, Cheng CD#, Li HX#, Sun XL, Duan RY, Zhu Y, Sun L, Chen FK, Bao ZY, Zhang Y, Shen JH. The Hospital-Community-Family–Based Telemedicine (HCFT-AF) Program for Integrative Management of Patients With Atrial Fibrillation: Pilot Feasibility Study. JMIR mHealth and uHealth, 2020,8(10):e22137. (IF 4.947/Q1, 共同一作)
(12)Sun X, Li H, Zhu Y, Xu P, Zuo Q, Li B, Gu X. 5-Azacytidine-Induced Cardiomyocyte Differentiation of Very Small Embryonic-Like Stem Cells. Stem Cells Int. 2020,9(8):51. (IF 5.131/Q2,共同作者)
(13)Cheng CD, Gu X, Li HX, Duan RY, Sun L, Zhang Y, Bao ZY, Shen JH, Chen FK, Zhu Y. Can men with atrial fibrillation really rest easy with a CHA2DS2-VASc score of 0?[J]. BMC cardiovascular disorders, 2019, 19(1):178. (IF 2.174/Q3,共同作者)
(14)Guo X#, Gu X#, Jiang J#, Li H#, Duan R, Zhang Y, Sun L, Bao Z, Shen J, Chen F. A Hospital-Community-Family–Based Telehealth Program for Patients With Chronic Heart Failure: Single-Arm, Prospective Feasibility Study[J]. JMIR mHealth and uHealth, 2019, 7(12): e13229. (IF 4.947/Q1, 共同一作)