擅长心血管病临床诊治和介入治疗，具有丰富临床经验和优秀技术水平。同时，聚焦临床问题，开展冠心病基础、临床、介入手术和预后等方面的系列研究，并取得初步研究成果：
一）动脉粥样硬化“易损性”和冠心病的基础研究
通过系列分子机制研究，阐述内皮功能障碍、SIRT6、TREM1因子及线粒体稳态与斑块易损性的关系。国际上首次发现并报道冠脉心肌桥特征性“FUSIFORM现象”及壁血管“腔小壁薄”的血管生物学特性。腔内影像学技术在体表征心梗患者少见“易损斑块”类型的组织特征（冠脉瘤样扩张、钙化结节病变）。获3项国家自然科学基金面上项目及2项上海市科委课题资助；共发表相关论文15篇 ，其中 SCI 12篇 (总IF 39.5，最高10.1)
二）急性心肌梗死的个体化治疗的基础和临床探索
从心梗的整体化治疗出发，对心梗的“特殊病变、抗血小板药物治疗、紧急再灌注策略、并发症预防和预后改善”等开展研究，提供个体化治疗的证据，包括：国人抗血小板药物的基因多态性与疗效；新型抗血小板改善心梗疗效及机制；应用新型QFR技术优化合并多支病变的急诊再灌注治疗策略；提出心梗术后“补救性”水化方案降低造影剂肾病，以及TREM-1预测心梗事件和死亡风险的危险分层。并尝试探索“斑块糜烂”在心梗患者的发生率、病理、临床特征及转归，筛选和验证早期预警生物标志物，降低剩余心血管风险。获上海市科委重点项目资助（300万）；发表相关论文8篇 ，其中 SCI 6 篇(总IF 23.7)；部分成果获上海医学会优秀论文二/三等奖。近年来带领团队筛选和验证心梗早期预警生物标志物，完成千余例心梗患者长期随访，同时基于QFR技术，致力探索心梗患者的个体化治疗策略。
三）国产化自主药物洗脱支架的研制和平台构建
在国内最先参与研制中国生物可降解涂层的药物洗脱支架（DES），并最早发表国内研究发现，为填补国内空白做出贡献。从事预防冠状动脉支架再狭窄的基础研究工作，协作建立包括药物支架涂层材料研究、抑制细胞增殖药物的筛选、药物作用机制的阐明、再狭窄动物模型的建立、药物支架疗效及安全性的评价等一套完整的研究体系。申请3项有关自主研制的药物支架的专利，其中2项为第二排名。2001年“国家863计划”资助（重要参与者）；2010年“上海市科技奖”一等奖（主要成员）；上海心血管病年会优秀论文一等奖（第一作者）；主持国家科技部子课题“国产三氧化二砷支架研制和临床应用”
四）优化冠心病介入及精准干预研究
在国内率先引入“支架失败”理念，开展系列冠心病介入技术研究：阐述国人左主干部位的血管生物学特征。国际上创新性提出“弥漫性支架扩张不良”机制是冠脉支架血栓的重要危险因素，并阐明其在支架再狭窄的机制差异，研究结果引发国际心血管同行的极大兴趣，杂志社同期刊文评论和在线视频评论，为改进单纯依赖造影指导介入技术做出重要贡献。在另一方面，阐述DES时代“支架边缘夹层和血肿”发生率、机制及造影不典型表现，为预防严重并发症且避免过多支架植入提供重要理论基础。上述研究结果被他引120余次，其中顶级心血管病杂志JACC、Circulation、European Heart Journal、AJC等40余次；并被写入《血管内超声在冠状动脉疾病中应用的中国专家共识2018》。
综上述，以第一或通讯作者在JACC Cardio intervention, JACC Imaging , JAHA, CCI等发表SCI文章60余篇，中文核心期刊杂志20余篇。出版书籍18本，其中副主编10本、教材1本；副主译1本。共主持国家自然基金项目、上海科委“科技创新行动计划”重点项目等14项，参与国家836、卫生部重点学科课题6项。作为主要完成人获上海市科学技术奖一等奖，中华医学科技奖三等奖，教育部科学技术进步奖一等奖，上海市科学技进步奖一等奖。获得上海市优秀学术带头人、上海市医学领军人才、上海市五一劳动奖章、上海市医务工匠、国之名医等荣誉。
主要科研项目：
上海市卫生健康委员会临床研究专项，“斑块侵蚀型”急性心肌梗死的免疫表征和疾病模型构建----基于前瞻性急性心梗专病队列研究，50万，2024年10月-2027年9月，202440145，主持（在研）
国家自然科学基金面上项目：核受体Sirt6调节内皮来源微颗粒生成机制及对泡沫细胞形成的抑制作用，55万，2022年1月-2025年12月，82170346，主持（在研）
上海市卫健委医学领军人才计划：急性心肌梗死患者分子生物学特征分析，45万，2019年7月-2022年6月，2019LJ10，主持
上海市科委“优秀学术带头人”计划：基于影像和无导丝生理功能评估的“一站式”技术优化急性心梗急诊血运重建策略的研究，40万，2019年5月-2022年4月，19XD1403300，主持
上海市科委“创新性行动计划”重点项目：基于多模态腔内影像和无创QFR技术的冠心病早起预警及个体化治疗方案研究，300万，2018年6月-2021年6月，18411950300，主持
国家自然科学基金面上项目：Sirt6经KLF4/PGC-1a调控内皮细胞线粒体稳态的机制及其在糖尿病性动脉粥样硬化中的作用，62万，2017年1月-2020年12月，81670403，主持
国家自然科学基金面上项目：TREM-1/DAP12/ NF-κB 信号通路在6-姜烯酚抗动脉粥样硬化中的作用研究，70万，2014年01月- 2017年12月，81370390，主持
上海市科委产学研医项目：注射用丹参多酚酸盐改善PCI术后疗效的临床研究，80万，2015年7月-2018年9月，15DZ1900300，子课题负责人
上海市科委自然基金项目：药物洗脱支架致动脉瘤样扩张和血栓形成微环境的机制研究，10万，2010年04月-2013年03月，10ZR1406600，主持
卫生部重点学科课题：急性冠脉综合征冠状动脉不稳定性斑块的识别及对临床预后的价值，240万，2007-2009，第三负责人
卫生部重点学科课题：冠心病患者斑块特性的早期识别及药物干预后转归的研究，240万，2010-2012，第三负责人
国家863计划科技支撑项目：药物涂层支架在冠心病应用的研制与应用，100万，2002年09月-2005年08月，2002AA326110，主要参与和完成者
国家自然科学基金委面上项目：载中药E药物支架预防再狭窄机制的研究，25万，2003年01月-2005年12月，主要执行和参与
国家科技部项目：新型三氧化二砷洗脱支架的临床应用，10万，2014年，国家科技部，负责人
主要编写书籍：
《血管内超声（第二版）》副主编，人民卫生出版社,2018
《2019现代心脏病学进展》副主编，科学出版社,2019.5
《2018现代心脏病学进展》副主编，科学出版社,2018.5
《血管内超声中国专家共识2016》主笔编者，中华心血管病杂志,2018.5
《2017现代心脏病学进展》副主编，科学出版社,2017.5
《OCT中国专家共识2016》编者，中华心血管病杂志,2017.1
《2016现代心脏病学进展》副主编，科学出版社,2016.5
《OCT临床应用进展》副主编，科学技术出版社,2015
《冠状动脉疾病影像学》副主编，北京大学医学出版社,2015
《2015现代心脏病学进展》副主编，科学出版社,2015
《2014现代心脏病学进展》副主编，复旦大学出版社,2014
《现代心脏病学》主编助理，复旦大学出版社,2011
《实用内科学（第13版）》编者，人民卫生出版社,2009
《冠状动脉慢性闭塞病变介入治疗》编者，人民卫生出版社,2009
《内科学》八年制医学生英文版教材 编者，人民卫生出版社,2007
《实用心脏病学（第4版）》编者，上海科技出版社,2007
《Handbook of Complications during Percutaneous Coronary Interventions》编者，CRC Press出版社,2006
奖项和荣誉：
2021年 上海市五一劳动奖章（上海市总工会）
2020年 国之名医·优秀风范（人民日报）
2019年 上海市“优秀学术带头人”
2019年 上海市“医学领军人才”
2019年 上海市“医务工匠”
2010年 上海市科学技术奖一等奖
2009年 上海市科学技术进步一等奖
2009年 教育部科学技术进步奖一等奖
2009年 中华医学科技奖三等奖
2005年 上海市科学技术进步一等奖
代表性论文：
Jia-Jie Wang, Yian Yao, Guoli Sun, Zi Ye, Hungchen Lin, Chengxing Liu, Yan Lai, Ying Zhang, Zhichao Zheng and Xuebo Liu. Sex differences in the association between cardiovascular risk factors and coronary artery calcification progression among individuals without coronary artery calcium. Biology of Sex Differences (2026) 17:6
Wei, Bao; Chengxing, Liu; Wen, Huang; Yan, Lai; Fei, Chen; Yian, Yao; Hung-Chen, Lin; Zi, Ye; Jun, Qian; Fan, Ping; Deqiang, Yuan; Kangwei, Wang; Yi, Hu; Xuebo, Liu. Dietary inflammatory potential and dietary quality in relation to advanced cardiovascular-kidney-metabolic syndrome and mortality risk: traditional and machine learning-based analysis. Nutrition Journal (2026) 25:20
Deqiang Yuan, Jun Qian, Hao Lin, Jiapeng Chu, Guoqi Zhu,Fei Chen and Xuebo Liu. Construction of a predictive model for in-hospital mortality in patients with acute myocardial infarction complicated with cardiogenic shock. Frontiers in Cardiovascular Medicine 2025.Oct
Chengxing, Liu; Yuntao, Feng; Fan, Ping; Litang, Huang; Jun, Qian; Li, Zhou; Fei, Chen; Xuebo, Liu. Association of magnesium depletion score with all-cause and cardiovascular mortality in hyperlipidemia adults: a large nationwide population-based study. Journal of Health, Population and Nutrition 2025 Aug 3;44(1):275
Yuntao Feng, Chengxing Liu, Litang Huang, Jun Qian, Na Li, Hongwei Tan and Xuebo Liu. Associations between heavy metal exposure and vascular age: a large cross‑sectional study. Journal of Translational Medicine (2025) 23:4
Yao, TQ; Xi, YH; Chen, F ; Lin, H; Qian, J; Liu, XB. Safety of human serum albumin infusion in heart failure patients with hypoproteinemia: a propensity score-matched analysis. CLINICS 2025;80
Hao, Lin; Tongqing, Yao; Haoran, Ding; Jiapeng, Chu; Deqiang, Yuan; Fan, Ping; Fei, Chen; Xuebo, Liu. Identification and functional characterization of differentially expressed circRNAs in high glucose treated endothelial cells: Construction of circRNA-miRNA-mRNA network. Heliyon 2024 Sep 15;10(17)
Yuntao, Feng; Hao, Lin; Hongwei, Tan; Xuebo, Liu. Life's essential 8 metrics and mortality outcomes in insulin resistance: The role of inflammation, vascular aging, and gender. Clin Nutr ESPEN 2024 Jun;61
Haoran, Ding; Jing, Tong; Hao, Lin; Fan, Ping; Tongqing, Yao; Zi, Ye; Jiapeng, Chu; Deqiang, Yuan; Kangwei, Wang; Xuebo, Liu; Fei, Chen. KLF4 inhibited the senescence-associated secretory phenotype in ox-LDL-treated endothelial cells via PDGFRA/NAMPT/mitochondrial ROS. Aging (Albany NY) 2024 May 08;16(9).
Yuntao, Feng; Hao, Lin; Hongwei, Tan; Xuebo, Liu. Heterogeneity of aging and mortality risk among individuals with hypertension: Insights from phenotypic age and phenotypic age acceleration. J Nutr Health Aging 2024 May;28(5)
Jiapeng, Chu; Yan, Lai; Yian, Yao; Wen, Ye; Tongqing, Yao; Hao, Lin; Deqiang, Yuan; Fan, Ping; Guoqi, Zhu; Haoran, Ding; Fei, Chen; Wenwen, Yan; Xuebo, Liu. The relationship between glycemic risk and longitudinal changes in total physiological atherosclerotic burden in patients with coronary artery disease. Quant Imaging Med Surg 2024 Apr 3;14(4):2904-2915
Jiapeng, Chu; Deqiang, Yuan; Yan, Lai; Wen, Ye; Lei, Liu; Hao, Lin; Fan, Ping; Guoqi, Zhu; Fei, Chen; Yian, Yao; Wenwen, Yan; Xuebo, Liu. Prognostic Implications of Changes in Total Physiological Atherosclerotic Burden in Patients With Coronary Artery Disease-A Serial QFR Study. Angiology 2023 Nov 23;0(0):33197231218616
Hao, Lin; Jiapeng, Chu; Deqiang, Yuan; Kangwei, Wang; Fei, Chen; Xuebo, Liu.MiR-206 may regulate mitochondrial ROS contribute to the progression of Myocardial infarction via TREM1.BMC Cardiovasc Disord 2023 Sep 20;23(1):470
Haoran, Ding; Guoqi, Zhu; Hao, Lin; Jiapeng, Chu; Deqiang, Yuan; Yi'an, Yao; Yanhua, Gao; Fei, Chen; Xuebo, Liu. Screening of Potential Circulating Diagnostic Biomarkers and Molecular Mechanisms of Systemic Lupus Erythematosus-Related Myocardial Infarction by Integrative Analysis.J Inflamm Res 2023;16(0):3119-3134
Guoqi, Zhu; Yanhua, Gao; Jun, Qian; Yan, Lai; Hao, Lin; Chengxing, Liu; Fei, Chen; Xuebo, Liu. Comprehensive analysis of atherosclerotic plaques reveals crucial genes and molecular mechanisms associated with plaque progression and rupture. Front Cardiovasc Med 2023;10(0):951242
Shengxian, Tu; Bo, Xu; Lianglong, Chen; Huihong, Hong; Zhiqing, Wang; Chunming, Li; Miao, Chu; Lei, Song; Changdong, Guan; Bo, Yu; Zening, Jin; Guosheng, Fu; Xuebo, Liu; Junqing, Yang; Yundai, Chen; Junbo, Ge; Shubin, Qiao; William, Wijns. Short-Term Risk Stratification of Non-Flow-Limiting Coronary Stenosis by Angiographically Derived Radial Wall Strain. J Am Coll Cardiol 2023 Feb 28;81(8):756-767
Jian-Ming, Wei; Yan-Li, Song; Huan, Zeng; Wen-Wen, Yan; Xue-Bo, Liu.Assessing causality between different risk factors and pulmonary embolism: A Mendelian randomization study. Front Cardiovasc Med 2023;10(0):1057019
Lei, Song; Bo, Xu; Shengxian, Tu; Changdong, Guan; Zening, Jin; Bo, Yu; Guosheng, Fu; Yujie, Zhou; Jian'an, Wang; Yundai, Chen; Jun, Pu; Lianglong, Chen; Xinkai, Qu; Junqing, Yang; Xuebo, Liu; Lijun, Guo; Chengxing, Shen; Yaojun, Zhang; Qi, Zhang; Hongwei, Pan; Rui, Zhang; Jian, Liu; Yanyan, Zhao; Yang, Wang; Kefei, Dou; Ajay J, Kirtane; Yongjian, Wu; William, Wijns; Weixian, Yang; Martin B, Leon; Shubin, Qiao; Gregg W, Stone. 2-Year Outcomes of Angiographic Quantitative Flow Ratio-Guided Coronary Interventions. J Am Coll Cardiol 2022 Nov 29;80(22):2089-2101
Jiapeng, Chu; Yan, Lai; Wenwen, Yan; Yian, Yao; Hao, Lin; Deqiang, Yuan; Fan, Ping; Guoqi, Zhu; Zi, Ye; Tongqing, Yao; Fei, Chen; Xuebo, Liu. Impact of Radial Wall Strain on Serial Changes in Vascular Physiology in Patients with Intermediate Coronary Stenosis. Rev Cardiovasc Med 2023 Aug;24(8):245
Deqiang, Yuan; Jiapeng, Chu; Jun, Qian; Hao, Lin; Guoqi, Zhu; Fei, Chen; Xuebo, Liu. New Concepts on the Pathophysiology of Acute Coronary Syndrome. Rev Cardiovasc Med 2023 Apr;24(4):112
Yuntao, Feng; Xuebo, Liu; Hongwei, Tan. Causal association of peripheral immune cell counts and atrial fibrillation: A Mendelian randomization study. Front Cardiovasc Med 2022;9(0):1042938
Deqiang, Yuan; Jiapeng, Chu; Hao, Lin; Guoqi, Zhu; Jun, Qian; Yunan, Yu; Tongqing, Yao; Fan, Ping; Fei, Chen; Xuebo, Liu. Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis. Front Cardiovasc Med 2022;9(0):1109445
Jiapeng, Chu; Hao, Lin; Wenwen, Yan; Deqiang, Yuan; Yan, Lai; Xuebo, Liu. Angiographic quantitative flow ratio in acute coronary syndrome: beyond a tool to define ischemia-causing stenosis-a literature review. Cardiovasc Diagn Ther 2022 Dec;12(6):892-907
Hong-Wei, Tan; Wei-Dong, Gao; Xin-Hua, Wang; Zhi-Song, Chen; Xue-Bo, Liu. A Four-Stepwise Electrocardiographic Algorithm for Differentiation of Ventricular Arrhythmias Originated from Left Ventricular Outflow Tract. J Clin Med 2022 Oct 28;11(21)
Jun, Qian; Yanhua, Gao; Yan, Lai; Zi, Ye; Yian, Yao; Keke, Ding; Jing, Tong; Hao, Lin; Guoqi, Zhu; Yunan, Yu; Haoran, Ding; Deqiang, Yuan; Jiapeng, Chu; Fei, Chen; Xuebo, Liu. Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Acute Myocardial Infarction. Front Immunol 2022;13(0):908815
Jing, Tong; Bing, Ji; Yan-Hua, Gao; Hao, Lin; Fan, Ping; Fei, Chen; Xue-Bo, Liu. Sirt6 regulates autophagy in AGE-treated endothelial cells via KLF4. Nutr Metab Cardiovasc Dis 2022 Mar;32(3):755-764
Guoqi, Zhu; Yan, Lai; Fei, Chen; Jun, Qian; Hao, Lin; Deqiang, Yuan; Tongqing, Yao; XueBo, Liu. Exploration of the Crucial Genes and Molecular Mechanisms Mediating Atherosclerosis and Abnormal Endothelial Shear Stress. Dis Markers 2022;2022(0):6306845
Jiani, Tang; Hanjing, Hou; Jiapeng, Chu; Fei, Chen; Yian, Yao; Yanhua, Gao; Zi, Ye; Shaowei, Zhuang; Yan, Lai; Xuebo, Liu. Clinical implication of quantitative flow ratio to predict clinical events after drug-coated balloon angioplasty in patients with in-stent restenosis. Clin Cardiol 2021 Jul;44(7):978-986
Jun, Qian; Lijun, Kuang; Fei, Chen; Xuebo, Liu; Lin, Che. Prognosis and management of new-onset atrial fibrillation in critically ill patients. BMC Cardiovasc Disord 2021 May 5;21(1):231
Hongwei, Tan; Zhisong, Chen; Fei, Chen; Wenjun, Xu; Xuebo, Liu. CKAP4 participates in tryptase-induced phenotypic conversion in atrial fibroblasts through PAR2/p38/JNK pathway. Am J Transl Res 2021;13(4):2270-2282
Zhi-Song, Chen; Hong-Wei, Tan; Hao-Ming, Song; Wen-Jun, Xu; Xue-Bo, Liu. Impact of corrected sinus node recovery time in predicting recurrence in patients with paroxysmal atrial fibrillation. J Int Med Res 2021 May;49(5):3000605211010103
Jun, Qian; Jiyong, Zan; Lijun, Kuang; Lin, Che; Yunan, Yu; Ting, Shen; Jiani, Tang; Fei, Chen; Xuebo, Liu. A predictive nomogram of bleeding risk in patients with atrial fibrillation after drug-eluting stent implantation. Ann Transl Med 2021 Feb;9(3):193
Jiani, Tang; Jiapeng, Chu; Hanjing, Hou; Yan, Lai; Shengxian, Tu; Fei, Chen; Yian, Yao; Zi, Ye; Yanhua, Gao; Yu, Mao; Shaowei, Zhuang; Xuebo, Liu. Clinical implication of QFR in patients with ST-segment elevation myocardial infarction after drug-eluting stent implantation. Int J Cardiovasc Imaging 2021 Mar;37(3):755-766
Jiani, Tang; Yan, Lai; Shengxian, Tu; Fei, Chen; Yian, Yao; Zi, Ye; Jianyun, Gu; Yanhua, Gao; Chunyu, Guan; Jiapeng, Chu; Cheng, Yang; Xuebo, Liu. Quantitative flow ratio-guided residual functional SYNTAX score for risk assessment in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. EuroIntervention 2021 Jul 20;17(4):e287-e293
Jun, Qian; Lijun, Kuang; Lin, Che; Fei, Chen; Xuebo, Liu. Maximum blood glucose levels during hospitalisation to predict mortality in patients with acute coronary syndrome: a retrospective cohort study. BMJ Open 2020 Dec 12;10(12):e042316
Jiapeng, Chu; Jiani, Tang; Yan, Lai; Yanhua, Gao; Zi, Ye; Chunyu, Guan; Keke, Ding; Yian, Yao; Fei, Chen; Xuebo, Liu. Association of stress hyperglycemia ratio with intracoronary thrombus burden in diabetic patients with ST-segment elevation myocardial infarction. J Thorac Dis 2020 Nov;12(11):6598-6608
Yun Kai, Wang; Jia Ni, Tang; Lu, Han; Xian Dong, Liu; Yun Li, Shen; Chun Yu, Zhang; Xue Bo, Liu. Elevated FURIN levels in predicting mortality and cardiovascular events in patients with acute myocardial infarction. Metabolism 2020 Oct;111(0):154323
Jie, Zhang; Jiaqi, Wang; Han, Yu; Guanghua, Wang; Junfang, Zhang; Rui, Zhu; Xuebo, Liu; Jue, Li. Comparison between Atorvastatin and Rosuvastatin on Secondary Percutaneous Coronary Intervention Rate and the Risk Factors in Patients with Coronary Heart Disease. Curr Drug Metab 2020;21(10):818-828
Ye, Zi; Yao, Yi-An; Ji, Bing; Lai, Yan; Tong, Jing; Guan, Chun-Yu; Ping, Fan; Lin, Hao; Tang, Jia-Ni; Hou, Han-Jin; Chen, Fei; Liu, Xue-Bo. Sirt6-induced autophagy restricted TREM-1-mediated pyroptosis in ox-LDL-treated endothelial cells: relevance to prognostication of patients with acute myocardial infarction. Cell Death Discov 2019;5(0):88
Zi Ye,Yan Lai,Yian Yao,Gary S. Mintz,Xuebo Liu .Optical coherence tomography and intravascular ultrasound assessment of the anatomic size and wall thickness of a muscle bridge segment. Catheter Cardiovasc Interv. 2019.2.21;1-7
Hongwei, Tan; Zhisong, Chen; Fei, Chen; Yian, Yao; Yan, Lai; Wenjun, Xu; Xuebo, Liu. Tryptase Promotes the Profibrotic Phenotype Transfer of Atrial Fibroblasts by PAR2 and PPARγ Pathway. Arch Med Res 2018 Nov;49(8):568-575
Yun Kai Wang,Jia Ni Tang,Jun Bo Ge,Xue Bo Liu,et al. Prognostic Utility of sTREM-1 in Predicting Mortality and Cardiovascular Events in Patients with Acute Myocardial Infarction. J AM Heart Assoc. 2018.6.19;7(12):e008985.
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