科研业绩
美国匹兹堡大学医学院进修1年，主攻血管生物学研究。
1.国家级课题：
主持国家自然科学基金项目：mTORC1/OPN信号通路在cathepsin L缺乏诱导血管衰老中的作用与机制。项目编号: 81871092；经费：56.00万元
主持国家自然科学基金项目：Cathepsin L通过SIRT1/p66Shc途径调控血管内皮细胞衰老的机制研究。项目编号: 81401158；经费：22.00万元
2.局级课题
主持申康发展中心临床研究培育项目：不同危险因素对血管衰老的影响。项目编号: SHDC12017X21；经费：30.00万元
3.临床研究课题
银杏酮酯片在2型糖尿病合并冠心病伴轻度认知功能障碍中的作用研究 2024.9-2026.12
主持，在研 项目编号:2023YJXYSA015；经费：48.22万元
3.近年发表的代表性学术论文
1.Pan X, Yu Y, Chen Y, Wang Y, Fu G. Cathepsin L was involved in vascular aging by mediating phenotypic transformation of vascular cells.Arch Gerontol Geriatr. 2023 Jan; 104:104828.
2.Jun Xu#; Yu Jie Deng#; Yi Wang; Xiao Fang Sun; Shu Qin Chen; Guo Xiang Fu*; SPAG5-AS1 inhibited autophagy and aggravated apoptosis of podocytes via SPAG5/AKT/mTOR pathway. Cell Proliferation. 2020 ,53(2): e12738.
3.Jian-Min Gao; Zeng-Hua Ren; Xin Pan; Y u-Xin Chen; Wei Zhu; Wei Li; Yan-Xi Yang; Guo-Xiang Fu*; Identifying peripheral arterial disease in the elderly patients using machine-learning algorithms. Aging Clin Exp Res. 2022:679-685.
4.Guo Xiang Fu*; Alex F. Chen; Qiu Mei Xu; Bei Bei Han; Gao Zhong Huang; Yuan Zhong; Cathepsin L deficiency results in reactive oxygen species (ROS)accumulation and vascular cells activation. Free Radical Research. 2017 ,51(11-12): 932-942.
5.Feng-Feng Pan; Chan-Chan Xu; Ting-Jun Hu; Guo-Xiang Fu*; Yuan Zhong; Carotid plague formation is associated with ankle-brachial index in elderly people. Aging Clin Exp Res. 2020 Nov;32(11):2217-2223.
6.Jun Xu; Feng Feng Pan; Chan Chan Xu; Yuan Zhong; Ting Jun Hu; Guo-Xiang Fu*. Plasma Cathepsin L Level is Positively Associated with Arterial Stiffness in Geriatric Patients. Artery Research.2019, 25(1-2): 65-69.
