长期从事心血管疾病尤其动脉粥样硬化疾病的相关基础与临床研究，作为主持人独立完成国家自然科学基金一项、上海市科委创新项目一项、中国心血管健康联盟基金两项、临床研究两项，作为主要负责人参与国家级、上海市、浙江省科委多个项目研究；在探索冠心病发病机制、冠脉植入支架前后计算机重建等方面积累了较丰富的经验，发表SCI论文20余篇。
Long-term engagement in basic and clinical research related to cardiovascular diseases, especially atherosclerosis. As the principal investigator, I have independently completed one National Natural Science Foundation project, two China Cardiovascular Health Alliance Foundation projects, and two clinical research projects. As the main person in charge, I have participated in multiple project researches at the national, Shanghai, and Zhejiang Provincial Science and Technology Commission levels. I have accumulated rich experience in exploring the pathogenesis of coronary heart disease and computer reconstruction before and after coronary stent implantation, and have published more than 20 SCI papers.
近3年文章(第一或通讯作者)：
1. Haoran Ding, Guoqi Zhu, Hao Lin, Jiapeng Chu, Deqiang Yuan, Yi’an Yao, Yanhua Gao, Fei Chen*, Xuebo Liu*. Screening of Potential Circulating Diagnostic Biomarkers and Molecular Mechanisms of Systemic Lupus Erythematosus-Related Myocardial Infarction by Integrative Analysis., Journal of Inflammation Research, 2023,16:3119-3134. (通讯作者)
2. Guoqi Zhu, Yanhua Gao, Jun Qian, Yan Lai, Hao Lin, Chengxing Liu, Fei Chen* and Xuebo Liu*. Comprehensive analysis of atherosclerotic plaques reveals crucial genes and molecular mechanisms associated with plaque progression and rupture. FRONTIERS IN CARDIOVASCULAR MEDICINE,2023:951542. (通讯作者)
3. Deqiang Yuan, Jiapeng Chu, Hao Lin, Guoqi Zhu, Jun Qian, Yunan Yu, Tongqing Yao, Fan Ping, Fei Chen* and Xuebo Liu*. Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis. FRONTIERS IN CARDIOVASCULAR MEDICINE,2023:1109445. (通讯作者)
4. Jun Qian, Yanhua Gao, Yan Lai, Zi Ye, Yian Yao, Keke Ding, Jing Tong, Hao Lin, Guoqi Zhu, Yunan Yu, Haoran Ding, Deqiang Yuan, Jiapeng Chu, Fei Chen* and Xuebo Liu*. Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Acute Myocardial Infarction. FRONTIERS IN IMMUNOLOGY,2022:908815. (通讯作者)
5. Jing Tong, Bing Ji, Yan-Hua Gao, Hao Lin, Fan Ping, Fei Chen*, Xue-Bo Liu*. Sirt6 regulates autophagy in AGE-treated endothelial cells via KLF4. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES,2022,32:755-764. (通讯作者)
6. Jun Qian, Jiyong Zan, Lijun Kuang, Lin Che, Yunan Yu, Ting Shen, Jiani Tang, Fei Chen*, Xuebo Liu*. A predictive nomogram of bleeding risk in patients with atrial fibrillation after drug-eluting stent implantation. Ann Transl Med, 2021,9(3):193. (通讯作者)
7. Jun Qian, Lijun Kuang, Lin Che, Fei Chen*, Xuebo Liu*. Maximum blood glucose levels during hospitalisation to predict mortality in patients with acute coronary syndrome: a retrospective cohort study. BMJ Open,2020,10:e042316. (通讯作者)
8. Xiaolu Jiang, Yanqiu Zeng, Shixiao Xiao*, Shaojie He, Caizhi Ye, Yu Qi, Jiangsheng Zhao, Dezhi Wei, Muhua Hu, Fei Chen*. Automatic Detection of Coronary Metallic Stent Struts Based on YOLOv3 and R-FCN. Computational and Mathematical Methods in Medicine. 2020:1793517. (通讯作者)
9. Ye Zi, Yao Yi-An, Ji Bing, Lai Yan, Tong Jing, Guan Chun-Yu, Ping Fan, Lin Hao, Tang Jia-Ni, Hou Han-Jin, Chen Fei*,Liu Xue-Bo*. Sirt6-induced autophagy restricted TREM-1-mediated pyroptosis in ox-LDL-treated endothelial cells: relevance to prognostication of patients with acute myocardial infarction. Cell death discovery. 2019,5:88. (通讯作者)
