1. 智能纳米药物及其在肿瘤化疗、光疗及免疫治疗中的应用(The design and application of intelligent nano-drugs in cancer chemotherapy, phototherapy and immunotherapy)

2. 活性/仿生型生物材料工程及其生物医学应用(The engineering of bioactive/biomimic-materials and their biomedical applications)

担任Theranostics，Biomaterials，Acs Applied Materials & Interfaces，Nanotechnology, Biology and Medicine，Nano Life，Journal of Nanomaterials 等期刊的审稿人。

主持承担科研项目:

（1）国家自然科学基金面上项目（2024-2027）；

（2）国家自然科学基金面上项目（2019-2022）；

（3）中央高校基本科研业务费专项资金（2017-2018）；

（4）国家自然科学基金青年基金项目（2015-2017）；

（5）中国博士后基金项目2项（2014-2015；2017-2018）；

（6）中国博士后特别资助基金（2014-2015）；

（7）杨浦区博士后创新实践基地科研项目（2014-2016）。

在ACS Nano、Advanced Science、Cell Reports、Adv Healthc Mater、Nano Research等国际高水平杂志上发表SCI论文20余篇。近期代表性成果：

1 Zichen Yang, Yuge Zhao, Xiaoyou Zhang, Li Huang, Kun wang, Jiuyuan Sun, Nana Chen, Weimin Yin, Shiyu Chen, Hui Zhi, Liangyi Xue, Lulu An, Rongjie Li, Haiqing Dong, Jinfu Xu*, Yan Li*, Yongyong Li*. Nano-mechanical Immunoengineering: Nanoparticle Elasticity Reprograms Tumor-Associated Macrophages via Piezo1. ACS Nano, 2024, DOI: 10.1021/acsnano.4c04614.

2 Zhang T, Yin W, Zhao Y, Huang L, Gu J, Zang J, Zheng X, Chang J, Sun J, Dong H, Li Y, Yan Li*. NOX2 Enzyme Mimicking Nano-Networks Regulate Tumor-Associated Macrophages to Initiate Both Innate and Adaptive Immune Effects. Adv Healthc Mater. 2023, e2302387.

3 Xiaoyi Ma, Bingbing Liu, Limin Fan, Yiqiong Liu, Yuge Zhao, Tianbin Ren*, Yan Li*, Yongyong Li*. Native and engineered exosomes for inflammatory disease. Nano Research, 2022，1.

4 Zhang T, Yang Y, Huang L, Liu Y, Chong G, Yin W, Dong H*, Li Yan*, Li Yongyong. Biomimetic and Materials-Potentiated Cell Engineering for Cancer Immunotherapy. Pharmaceutics, 2022, 14, 734. (SCI, IF: 6.525)

5 Yan Li, Yi Han, Runping Su, Yiqiong Liu, Gaowei Chong, Dailin Xu, Ruiqing He, Ying Liu, Haiqing Dong, Donglu Shi, Yongyong Li*. Photosensitizer-laden Neutrophils Remotely Controlled for Cancer Immunotherapy. Cell Reports, 2020, 33, 108499.

6 Yan Li, Lianghua He, Haiqing Dong, Yiqiong Liu, Kun Wang, Ang Li, Tianbin Ren, Donglu Shi, Yongyong Li*. Fever-inspired Immunotherapy Based on Photothermal CpG Nanotherapeutics: The Critical Role of Mild Heat in Regulating Tumor Microenvironment. Advanced Science, 2018,1700805,1.

7 Dou Du, Kun Wang, Ya Wen, Yan Li*, Yongyong Li*. Photodynamic Graphene Quantum Dot: Reduction Condition Regulated Photo-activity and Size Dependent Efficacy. ACS Applied Materials & Interfaces, 2016, 8, 3287.