【主持承担科研项目】
（1）国家自然科学基金面上项目（2024-2027）；
（2）国家自然科学基金面上项目（2019-2022）；
（3）中央高校基本科研业务费专项资金（2017-2018）；
（4）国家自然科学基金青年基金项目（2015-2017）；
（5）中国博士后基金项目2项（2014-2015；2017-2018）；
（6）中国博士后特别资助基金（2014-2015）；
（7）杨浦区博士后创新实践基地科研项目（2014-2016）
在Advanced Functional Materials、ACS Nano、Advanced Science、Cell Reports、Biomaterials、J Control Release、ACS Applied Materials & Interfaces、Nano Research等国际高水平杂志上发表SCI论文30余篇。
【近期代表性成果】
1 Lulu An, Yiqiong Liu, Zichen Yang, Rongjie Li, Weimin Yin, Haiqing Dong, Yan Li*, Yongyong Li*. Intracellular Delivery of CRISPR/Cas9 via Living Bacteria to Block Arginine Metabolic Reprogramming and Enhance Tumor Chemotherapy Sensitivity. Advanced Functional Materials, 2025, e04296.
2 Li Huang, Ying Luo, Le Kuai, Xiaoyou Zhang, Ying Zhang, Zichen Yang, Xiaoya Fei, Jiuyuan Sun, Yue Luo, Yuge Zhao, Tingting Xue, Weimin Yin, Jiao Chang, Jiankun Song, Yongyong Li*, Bin Li*, Yan Li*. An approach for psoriasis of microneedle patch simultaneously targeting multiple inflammatory cytokines and relapse related T cells. Biomaterials. 2025, 318, 123120.
3 Xiaoyou Zhang, Rongjie Li, Zichen Yang, Yanni Cai, Caoyi You, Hui Zhi, Shiyu Chen, Haiqing Dong, Weimin Yin, Lulu An, Yongyong Li*, Yan Li*. Nano-mechanochemical synergistic approach to reprogram tumor-associated macrophages for tumor immunotherapy. J Control Release. 2025, 385, 114062.
4 Zichen Yang, Yuge Zhao, Xiaoyou Zhang, Li Huang, Kun Wang, Jiuyuan Sun, Nana Chen, Weimin Yin, Shiyu Chen, Hui Zhi, Liangyi Xue, Lulu An, Rongjie Li, Haiqing Dong, Jinfu Xu*, Yan Li*, Yongyong Li*. Nano-mechanical Immunoengineering: Nanoparticle Elasticity Reprograms Tumor-Associated Macrophages via Piezo1. ACS Nano. 2024, 18(32), 21221-21235.
5 Zhang T, Yin W, Zhao Y, Huang L, Gu J, Zang J, Zheng X, Chang J, Sun J, Dong H, Li Y, Yan Li*. NOX2 Enzyme Mimicking Nano-Networks Regulate Tumor-Associated Macrophages to Initiate Both Innate and Adaptive Immune Effects. Adv Healthc Mater. 2023, e2302387.
6 Xiaoyi Ma, Bingbing Liu, Limin Fan,Yiqiong Liu, Yuge Zhao, Tianbin Ren*, Yan Li*, Yongyong Li*. Native and engineered exosomes for inflammatory disease. Nano Research, 2023, 16(5): 6991-7006.
7 Zhang T, Yang Y, Huang L, Liu Y, Chong G, Yin W, Dong H*, Li Yan*, LiYongyong. Biomimetic and Materials-Potentiated Cell Engineering for Cancer Immunotherapy. Pharmaceutics, 2022, 14, 734.
8 Yan Li, Yi Han, Runping Su,Yiqiong Liu, Gaowei Chong, Dailin Xu, Ruiqing He, Ying Liu, Haiqing Dong,Donglu Shi, Yongyong Li*. Photosensitizer-laden Neutrophils Remotely Controlled for Cancer Immunotherapy. Cell Reports, 2020, 33, 108499.
9 Yan Li, Lianghua He,Haiqing Dong, Yiqiong Liu, Kun Wang, Ang Li, Tianbin Ren, Donglu Shi, YongyongLi*. Fever-inspired Immunotherapy Based on Photothermal CpG Nanotherapeutics: The Critical Role of Mild Heat in Regulating Tumor Microenvironment. Advanced Science, 2018,1700805,1.
10 Dou Du, Kun Wang, Ya Wen,Yan Li*, Yongyong Li*. PhotodynamicGraphene Quantum Dot: Reduction Condition Regulated Photo-activity and Size Dependent Efficacy. ACS Applied Materials & Interfaces, 2016, 8, 3287.
