1.纳米医学与肠道微生态交叉领域基础研究、临床转化；

2.靶向纳米药物递送系统及抗肿瘤治疗；

3.新型纳米制剂及其在炎症/骨修复/肿瘤微环境/神经调控中的应用;

4.工程化益生菌在炎症或神经调节上的机制研究。

1. Basic research and clinical transformation in the cross-field of nanomedicine and intestinal microecology;

2. Targeted nanomedicine delivery system and anti-tumor therapy;

3. Novel nanomaterials and their applications in inflammation/bone repair/tumor microenvironment/neuroregulation;

4. Study on the mechanism of engineered probiotics on inflammation or neuroregulation.

上海第二军医大学药学院药剂学博士，同济大学生物材料博士后，同济大学博士研究生导师、研究员，上海市第十人民医院临床研究中心主任，纳米医学和肠道微生态课题组组长。

学术任职：中国医药教育协会临床研究工作委员会常务委员，上海市医学会肠内肠外营养专科分会青年委员，中国医药卫生文化协会医工融合分会委员及学会细胞治疗技术和设备学组青年学组主委，上海市第十人民医院临床研究学生委员会委员，细胞治疗学术委员会副主任委员等。

Ph.D. in Pharmacy from the School of Pharmacy, Shanghai Second Military Medical University, postdoctoral fellow in biomaterials at Tongji University, doctoral supervisor and researcher at Tongji University. Director of the Clinical Research Center of Shanghai Tenth People’s Hospital, and leader of the Nanomedicine and Intestinal Microecology Research Center.

Academic positions: Executive member of the Clinical Research Working Committee of the China Medical Education Association, young member of the Intestinal and Parenteral Nutrition Specialized Branch of the Shanghai Medical Association, member of the Medical Integration Branch of the China Medical and Health Culture Association, and chairman of the Youth Study Group of the Cell Therapy Technology and Equipment Group of the Society, member of the Clinical Research Student Committee of the Shanghai 10th People’s Hospital, and vice chairman of the Cell Therapy Academic Committee.

申请国家发明专利20余项，作为副主编编写人民卫生出版社书籍《临床肠道微生态学》，在国际顶级纳米杂志Signal transduction and targeted therapy, Advanced Materials, Nano.Today，Adv.Funct.Mater.，ACS nano, Biomaterials, In J Pharm等发表论文20余篇，总计IF为300余分，单篇最高IF=39.3，单篇最高引用205次。先后主持国家自然科学基金面上项目、青年项目、上海市科委基础重大项目子课题、上海市科委自然科学基金面上项目、上海交大医工交叉面上项目等多项科研项目。

Applied for more than 20 national invention patents, and worked as a deputy editor to write the book "Clinical Intestinal Microecology" by the People’s Health Publishing House. Published more than 20 papers in top international nano journals such as Signal transduction and targeted therapy, Advanced Materials, Nano.Today，Adv.Funct.Mater.，ACS nano, Biomaterials, In J Pharm, with a total IF score of over 300 points. The highest IF for a single article is 39.3, and the highest citation for a single article is 205 times. Has successively led multiple scientific research projects, including The National Natural Science Foundation of China, Shanghai Municipal Science and Technology Commission Basic Major Project Sub project, Shanghai Municipal Science and Technology Commission Natural Science Foundation General Project, Shanghai Jiao Tong University Medical and Industrial Intersection Project, and so on.

代表性文章：

1. Yang Yang, Yefei Zhu, Kairuo Wang, Yunqiu Miao, Yuanyuan Zhang, Jie Gao*, Huanlong Qin*, Yang Zhang*. Activation of Autophagy by in situ Zn2+ Chelation Reaction for Enhanced Tumor Chemo-Immunotherapy. Bioactive materials. 2023. （通讯 IF2022：18.9） （原位Zn2+螯合反应激活自噬增强肿瘤化学免疫治疗）

2. Xinyue Wang, Qian Chen*, Yefei Zhu, Kairuo Wang, Yongliang Chang, Xiawei Wu, Weichao Bao, Tongcheng Cao, Hangrong Chen, Yang Zhang*， Huanlong Qin*. Destroying Pathogen-Tumor Symbionts Synergizing with Catalytic Therapy of Colorectal Cancer by Biomimetic Protein-supported Single-Atom Nanozyme. Signal transduction and targeted therapy. 2023. （通讯 IF2022: 39.3）（生物模拟蛋白支持的单原子纳米酶协同破坏病原体-肿瘤共生体催化治疗结直肠癌癌症）

3. Kairuo Wang; Qian Chen; Li Ding; Yefei Zhu; Xinyue Wang; Mengting Zhou; Meiqi Chang; Manman Pei; Yuanyuan Zhang; Yang Zhang*; Yu Chen*；Huanlong Qin*. Mucoadhesive probiotic-based oral microcarriers with prolonged intestinal retention for inflammatory bowel disease therapy. Nano today. 2023. （通讯 IF2022: 17.4）（基于益生菌的口腔微载体延长肠道滞留时间用于炎症性肠病治疗）

4. Xiao Qu, Fang Yin, Manman Pei, Qian Chen*, Yuanyuan Zhang, Shengwei Lu, Xuelian Zhang, Ziyuan Liu, Xinyao Li, Hangrong Chen, Yang Zhang*, Huanlong Qin*. Modulation of Intratumoral Fusobacterium nucleatum to Enhance Sonodynamic Therapy for Colorectal Cancer with Reduced Phototoxic Skin Injury. 2023. ACS nano. （通讯 IF2022: 17.1）（调节瘤内具核梭杆菌增强声动力治疗结直肠癌减少光毒性皮肤损伤）

5. Jiahao Du, Mengting Zhou, Qian Chen,* Yichao Tao, Jun Ren, Yang Zhang*, Huanlong Qin*. Disrupting Intracellular Iron Homeostasis by Engineered Metal-Organic Framework for Nanocatalytic Tumor Therapy in Synergy with Autophagy Amplification-Promoted Ferroptosis. Adv. Funct. Mater. 2023. （通讯 IF2022: 19）（通过工程金属-有机框架破坏细胞内铁稳态协同自噬扩增促进铁凋亡的纳米催化肿瘤治疗）

6. Manman Pei, Kaiyuan Liu, Xiao Qu, Kairuo Wang, Qian Chen, Yuanyuan Zhang, Xinyue Wang, Zheng Wang, Xinyao Li, Feng Chen*, Huanlong Qin*, Yang Zhang*. Enzyme-catalyzed synthesis of selenium-doped manganese phosphate for synergistic therapy of drug-resistant colorectal cancer. J Nanobiotechnology. 2023. （通讯 IF2022: 10.2）（酶催化合成硒掺杂磷酸锰协同治疗耐药结直肠癌）

7. Yuanyuan Zhang, Qian Chen, Yefei Zhu, Manman Pei, Kairuo Wang, Xiao Qu, Yang Zhang*, Jie Gao*, Huanlong Qin*. Targeting inorganic nanoparticles to tumors using biological membrane-coated technology. MedComm. 2022.（通讯 IF2022: 9.9）（利用生物膜涂层技术靶向无机纳米粒子治疗肿瘤）

8. Ming Yang, Yang Zhang, Chao Fang, Li Song, Ying Wang, Lu Lu, Ranxing Yang, Zhaoting Bu, Xiayi Liang, Kun Zhang, Qiang Fu. Urine-Microenvironment-Initiated Composite Hydrogel Patch Reconfiguration Propels Scarless Memory Repair and Reinvigoration of the Urethra. Advanced Materials. 2022. （一作 IF2022: 29.4）（尿液微环境引发的复合水凝胶贴片重构促进尿道无瘢痕记忆修复和再生）

9. MiaoWang, QianChen, DongXu, ZebinYang, JufengChen, YangZhang*, HangrongChen*. Self-cycling Redox Nanoplatform in Synergy with Mild Magnetothermal and Autophagy Inhibition for Efficient Cancer Therapy. Nano today. 2022.（通讯 IF2022: 17.1）（自循环氧化还原纳米平台与温和磁热和自噬抑制协同作用用于有效的癌症治疗）

10.Keyi Wang, Yang Zhang, Weipu Mao, Wei Feng, Shuting Lu, Jian Wan, Xinran Song, Yu Chen, Bo Peng. Engineering Ultrasmall Ferroptosis-Targeting and Reactive Oxygen/Nitrogen Species-Scavenging Nanozyme for Alleviating Acute Kidney Injury. Adv. Funct. Mater. 2022.（一作 IF2022: 19）（工程超微铁靶向和活性氧/氮清除纳米酶减轻急性肾损伤）