长期聚焦抗真菌药物的研究与开发、药物靶点研究、荧光探针及其应用。主持承担国家自然科学基金重点项目和面上项目8项、新药创制科技重大专项2项、上海市级项目4项。近五年以通讯作者或共同通讯作者发表论文20余篇，申请专利6项，授权并转化专利3项，获批新药证书2件，获得2020年教育部科技进步一等奖1项（第1）。
近三年主持的部分基金课题：
1.重大新药创制科技重大专项，2019ZX09721001-001-006，抗耐药真菌新药NT-2的临床前研究，164.68万元，2019-2020
2.国家自然科学基金重点项目，81830106，基于抗耐药真菌新先导物和新机制的药物发现研究，293 万元，2019/01-2023/12
3.国家自然科学基金面上项目，82173786，基于活细胞特异荧光探针检测的真菌CYP51抑制剂实时原位构效关系探索及其作为抗真菌药物发现新方法研究，55 万元，2022/01-2025/12
4.上海市专项项目，抗耐药真菌药物研究，500 万元，2020/03-2022/03
5.上海市 “科技创新行动计划”生物医药科技支撑专项项目, 21S11901300，新型高效抗隐球菌活性化合物的作用机制与结构优化研究, 30万元，2021/07/01-2024/06/30
6.国家自然科学基金面上项目，81673280，新型氮唑类抗真菌先导物结构优化及其与靶酶结合模式研究，52 万元，2017/01-2020/12
近三年发表的部分发表论文：
1.Liping Li#, Hao Wu#, Shuo Zhu, Zhe Ji, Xiaochen Chi, Fei Xie, Yumeng Hao, Hui Lu, Feng Yang, Lan Yan, Dazhi Zhang*, Yuanying Jiang*, and Tingjunhong Ni*. Discovery of Novel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide Derivatives with Potent and Selective Antifungal Activity against Cryptococcus Species. J. Med. Chem. 2022, 65(16):11257-11269
2.Tingjunhong Ni †, Zichao Ding †, Fei Xie †, Yumeng Hao, Junhe Bao, Jingxiang Zhang, Shichong Yu*,Yuanying Jiang* and Dazhi Zhang*. Design, Synthesis, and In Vitro and In Vivo Antifungal Activity of Novel Triazoles Containing henylethynyl Pyrazole Side Chains. Molecules. 2022; 27(11): 3370.
3.Liping Li#, Hui Lu#, Xuan Zhang, Malcolm Whiteway, Hao Wu, Shanlun Tan, Jianye Zang, Shujuan Tian, Cheng Zhen, Xianlei Meng, Wanqian Li, Dazhi Zhang*, Min Zhang*, Yuanying Jiang*. Baicalein Acts against Candida albicans by Targeting Eno1 and Inhibiting Glycolysis. Microbiol Spectr. 2022;e0208522.
4.Ning Wang#, Yumeng Hao#, Xiaowei Feng, Haidan Zhu, Dazhi Zhang, Ting Wang∗, Xiaoyan Cui,∗. Silicon-substituted rhodamines for stimulated emission depletion fluorescence nanoscopy. Chinese Chemical Letters. 33 (2022) 133–140
5.Xiaofeng Lin#, Mengting Fan#, Ni Li, Jiaojiao Yang, Haidan Zhu, Bo Chen, Junru Zhu, Dazhi Zhang*, Ting Wang*, Xiaoyan Cui*. Phosphorus-substituted rhodamines for bioimaging of the lysosomal peroxynitrite in vivo. Dyes and Pigments 2022，201: 110201
6.Mengting Fan, Haiyan An, Chuanfeng Wang, Shuhui Huo, Ting Wang*, Xiaoyan Cui*, Dazhi Zhang*. STED imaging the dynamic of lysosomes by dually fluorogenic Si-rhodamine. Chemistry-A European Journal, 2021,27(37): 9620-9626
7.Huai-Huai Dong, Yuan-Hua Wang, Xue-Mi Peng, He-Yang Zhou, Fei Zhao, Yuan-Ying Jiang, Da-Zhi Zhang*, Yong-Sheng Jin*. Synergistic antifungal effects of curcumin derivatives as fungal biofilm inhibitors with fluconazole. Chem Biol Drug Des. 2021,97(5): 1079-1088
8.Zichao Ding#; Chuanfeng Wang#; Mengting Fan; Mengyuan Zhang; Yao Zhou; Xiaoyan Cui*; Dazhi Zhang*, Ting Wang*. Far-red imaging of b-galactosidase through a phospha-fluorescein. Chem. Commun.; 2020,56, 13579
9.Quan-Zhen Lv,Ting-Jun-Hong Ni,Li-Ping Li,Tian Li,Da-Zhi Zhang*, Yuan-Ying Jiang*. A New Antifungal Agent (4-phenyl-1, 3-thiazol-2-yl) Hydrazine Induces Oxidative Damage in Candida albicans. Front Cell Infect Microbiol. 2020;10:578956,
10.Fei Xie#; Tingjunhong Ni#; Zichao Ding#; Yumeng Hao; Ruina Wang; Ruilian Wang; Ting Wang; Xiaoyun Chai; Shichong Yu; Yongsheng Jin; Yuanying Jiang*; Dazhi Zhang*. Design, synthesis, and in vitro evaluation of novel triazole analogues featuring isoxazole moieties as antifungal agents. Bioorg Chem. 2020;101:103982
11.Ren-Yi Lu#; Ting-Jun-Hong Ni#; Jing Wu#; Lan Yan; Quan-Zhen Lv; Li-Ping Li; Da-Zhi Zhang*; Yuan-Ying Jiang*. New Triazole NT-a9 Has Potent Antifungal Efficacy against Cryptococcus neoformans In Vitro and In Vivo. Antimicrob Agents Chemother 2020;64(2)：e01628-19
12.Xin Huang#; Yu Liu#; Tingjunhong Ni#; Liping Li; Lan Yan; Maomao An; Dazhi Zhang*; Yuanying Jiang*. 11g, a Potent Antifungal Candidate, Enhances Candida albicans Immunogenicity by Unmasking β-Glucan in Fungal Cell Wall. Front Microbiol 2020;11:1324
