承担课题:
国家重大科学研究计划(2020YFA0113102):临床级 hUC-MSC 的标准化生产、质控和临床前研究,课题组长。
国家自然科学基金面上项目(81770942):关键转录因子诱导间充质干细胞分化为视网膜色素上皮细胞的机制及功能研究(2018/1-2021/12),主持。
国家自然科学基金面上项目(81372071):PUFA衍生物调节巨噬细胞极化状态促进糖尿病感染性溃疡创面修复的作用及机制研究(2014/1-2017/12),主持。
国家重大科学研究计划(2015CB964601):眼上皮成体干细胞原位再生治疗重要致盲眼病的机理研究(2015/1-2019/12),骨干。
国家重大科学研究计划(2013CB967501):干细胞治疗视网膜变性的基础与临床转化研究(2013/1-2017/12),骨干。
横向课题(kh0150020240729 ):优化诱导人iPSC分化视网膜色素上皮细胞技术的GMP工艺,主持(2024/4-2028/4)。
发表文章:
1.Zhu T, Li Y, Zhu L, Xu J, Feng Z, Chen H, Shi S, Liu C, Ou Q, Gao F, Zhang J, Jin C, Xu J, Li J, Zhang J, Bi Y, Xu GT, Wang J, Tian H, Lu L. GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model. Glia. 2024 Mar;72(3):504-528.
2.Li D, Ou Q, Shen Q, Lu MM, Xu JY, Jin C, Gao F, Wang J, Zhang J, Zhang J, Li J, Lu L, Xu GT, Tian H. Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response Stem Cell Res Ther. 2023 Oct 2;14(1):281
3.Shi S, Gu H, Xu J, Sun W, Liu C, Zhu T, Wang J, Gao F, Zhang J, Ou Q, Jin C, Xu J, Chen H, Li J, Xu G*, Tian H*, Lu L*. Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity. Exp Mol Med. 2023 May;55(5):898-909.
4.Zhu X, Chen Z, Wang L, Ou Q, Feng Z, Xiao H, Shen Q, Li Y, Jin C, Xu JY, Gao F, Wang J, Zhang J, Zhang J, Xu Z, Xu GT*, Lu L*, Tian H*. Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration. Cell Death Dis. 2022;13(9):785.
5.Tian H, Chen Z, Zhu X, Ou Q, Wang Z, Wu B, Xu JY, Jin C, Gao F, Wang J, Zhang J, Zhang J, Lu L*, Xu GT*. Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration. iScience (2022), doi: https://doi.org/10.1016/j.isci. 2022.105050.
6.Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H*, Xu GT*, Lu L*. Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy. Redox Biol. 2022 Jun;52:102292.