主要从事化学生物学、超分子自组装与振动光学成像的交叉研究，聚焦重大疾病相关生化反应的时空解析与精准干预。发展新型中红外光热（MIP）与受激拉曼散射（SRS）成像技术及化学探针，实现活细胞和组织中酶活性、代谢过程及生物分子组装状态的高分辨可视化；构建酶响应型超分子自组装体系，调控癌细胞代谢重编程并探索选择性干预策略。
My research focuses on the interdisciplinary integration of chemical biology, supramolecular self-assembly, and vibrational optical imaging, with an emphasis on the spatiotemporal characterization and precise modulation of biochemical reactions associated with major diseases. I develop advanced mid-infrared photothermal (MIP) and stimulated Raman scattering (SRS) imaging technologies and chemical probes to enable high-resolution visualization of enzyme activities, metabolic processes, and biomolecular assembly states in living cells and tissues. In parallel, I design enzyme-responsive supramolecular self-assembly systems to modulate metabolic reprogramming in cancer cells and explore strategies for selective therapeutic intervention.
发展了基于中红外光热（MIP）和受激拉曼散射（SRS）的高灵敏度化学成像技术，建立了活细胞和组织中酶活性、代谢过程及生物分子组装状态的时空解析方法；设计了具有生物响应性的化学探针与超分子自组装体系，实现了细胞内生化反应的可视化及癌细胞代谢重编程的精准调控，为重大疾病的机制研究与干预策略开发提供了新的技术手段。相关研究成果发表于 Nature Methods、Journal of the American Chemical Society、Angewandte Chemie International Edition、ACS Nano、Advanced Healthcare Materials 等国际知名学术期刊。累计发表学术论文 50余篇，其中第一作者及共同第一作者论文 11篇，获授权美国专利 1项。研究成果受到 Chemical & Engineering News（C&EN）、Nature Reviews Chemistry 等国际知名学术媒体和期刊的关注与报道。
Developed highly sensitive chemical imaging technologies based on mid-infrared photothermal (MIP) microscopy and stimulated Raman scattering (SRS) microscopy, establishing methods for spatiotemporally resolved visualization of enzyme activities, metabolic processes, and biomolecular assembly states in living cells and tissues. Designed bioresponsive chemical probes and supramolecular self-assembly systems to enable the visualization of intracellular biochemical reactions and the precise modulation of metabolic reprogramming in cancer cells, providing new tools for investigating disease mechanisms and developing targeted therapeutic strategies.
These research achievements have been published in prestigious international journals, including Nature Methods, Journal of the American Chemical Society, Angewandte Chemie International Edition, ACS Nano, and Advanced Healthcare Materials. To date, I have authored or co-authored over 50 peer-reviewed publications, including 11 first-author or co-first-author papers, and hold one granted U.S. patent. My research has attracted attention and coverage from prominent scientific publications, including Chemical & Engineering News (C&EN) and Nature Reviews Chemistry.
In recognition of my research achievements and scientific potential, I was selected for a prestigious national overseas high-level talent recruitment program in China in 2025.
