吕诚,同济大学医学院助理教授,硕士生导师,研究方向为DNA纳米技术的生物医学应用。博士毕业于武汉大学化学与分子科学学院化学基地班,导师为国家杰出青年基金获得者庞代文教授。后进入上海交通大学医学院分子医学研究院从事博士后研究,入选上海交通大学医学院博士后激励计划,主持博士后科学基金项目,合作导师为中科院院士谭蔚泓教授、国家杰出青年基金获得者韩达研究员。出站后加入同济大学医学院,入选上海市青年科技英才扬帆计划,主持国家自然科学基金面上项目,国家自然科学基金青年项目、上海市科委专项定向项目子课题、同济大学自主原创基础研究项目等多个课题。近年来以第一作者/通讯作者身份发表论文10篇,包括ACS Nano,Nano Lett.,Adv. Funct. Mater.,Biomaterials,Anal. Chem.等一区期刊,总引用次数近160次,单篇最高引用45次。
【代表性文章】
Lv, C.; Li, Y.; Zhang, M.; Cheng, Y.;* Han, D.* and Tan, W.*, Sequential Control of Cellular Interactions Using Dynamic DNA Displacement. Nano lett. 2023, 23, 1167-1174.
Li, Y.; Chen, X.; Lv, C.* and Cheng, Y.*, Ethane Groups Modified DNA Nanopores to Prolong the Dwell Time on Live Cell Membranes for Transmembrane Transport. Front. Chem. 2023, 11, 1148699.
Li, L.; Yuan, G.; Qi, Q.; Lv, C.;* Liang, J.; Li, H.; Cao, L.; Zhang, X.; Wang, S.; Cheng, Y. and He, H.*, Synthesis of tetraphenylethene-based D-A conjugated molecules with near-infrared AIE features, and their application in photodynamic therapy. J. Mater. Chem. B 2022, 10, 3550-3559.
Lv, C.; Ao, J.; Wang, J.; Tang, M.; Liu, A.* and Pang, D., Host-cell-assisted construction of folate-engineered nanocarrier based on viral light particle for targeted cancer therapy. Nanoscale 2021, 13, 17881-17889.
Yuan, G.;# Lv, C.;# Liang, J.; Zhong, X.; Li, Y.; He, J.; Zhao, A.; Li, L.; Shao, Y.; Zhang, X.; Wang, S.; Cheng, Y.* and He, H.*, Molecular Engineering of Efficient Singlet Oxygen Generators with Near-Infrared AIE features for Mitochondrial Targeted Photodynamic Therapy. Adv. Funct. Mater. 2021, 31, 2104026.
Lv, C.;# Gu, X.;# Li, H.; Zhao, Y.; Yang, D.; Yu, W.;* Han, D.;* Li, J. and Tan, W.*, Molecular Transport through a Biomimetic DNA Channel on Live Cell Membranes. ACS Nano 2020, 14, 14616-14626.
Lv, C.; Yang, C.; Ding, D.; Sun, Y.; Wang, R.; Han, D.* and Tan, W.*, Endocytic Pathways and Intracellular Transport of Aptamer-drug Conjugates in Live Cells Monitored by Single-particle Tracking. Anal. Chem. 2019, 91, 13818-13823.
Lv, C.; Zhang, T.; Lin, Y.; Tang, M.; Zhai, C.; Xia, H.; Wang, J.; Zhang, Z.; Xie, Z.; Chen, G. and Pang, D.*, Transformation of Viral Light Particles into Near-Infrared Fluorescence Quantum Dots-Labeled Active Tumor-Targeting Nanovectors for Drug Delivery. Nano lett. 2019, 19, 7035-7042.
Lv, C.; Lin, Y.; Sun, E.; Tang, B.; Ao, J.; Wang, J.; Zhang, Z.; Zheng, Z.; Wang, H. and Pang, D.*, Internalization of Pseudorabies Virus via Macropinocytosis Analyzed by Quantum Dot-based Single-Virus Tracking. Chem. Commun. 2018, 54, 11184-11187.
Lv, C.; Lin, Y.; Liu, A.; Hong, Z.; Wen, L.; Zhang, Z.; Zhang, Z.; Wang, H. and Pang, D.*, Labeling Viral Envelope Lipids with Quantum Dots by Harnessing the Biotinylated Lipid-Self-Inserted Cellular Membrane. Biomaterials 2016, 106, 69-77.
【主持科研项目】
国家自然科学基金面上项目“磁热调控DNA仿生纳米通道治疗骨癌痛的机制研究”(项目编号:82372107);
国家青年科学基金项目“基于单颗粒示踪技术的核酸适体药物偶联物与肿瘤细胞的作用机制研究”(项目编号:22007073);
上海市扬帆计划“单颗粒水平上对核酸适体药物偶联物治疗脑肿瘤的机制研究”(项目编号:20YF1452100);
上海市2020年度军民融合专项定向项目子课题“基于仿趋磁细菌微纳机器人集群的磁感知技术研究”(项目编号:20dz1101203);
同济大学自主原创基础研究项目“程序化动态调控多细胞间通讯策略的构建” (项目编号:22120210585);
中国博士后科学基金项目“基于单颗粒示踪技术核酸适体靶向性及进胞机制的研究”(项目编号:2018M642033);
胚胎干细胞研究湖北省重点实验室开放项目“肿瘤干细胞多模态标记及成像技术研究”(项目编号:2021ESOF002)。