陈炳地，博士，现任同济大学医学院副研究员，上海市分子诊断创新技术研究所CTC中心主任。重点从事肿瘤液体活检、AI+细胞病理和癌症康复治疗研究。与海外特聘教授、美籍华人科学家崔征教授合作，在全世界首创粒细胞抗癌疗法。通过医工交叉，结合纳米技术，开展癌症的诊断、治疗、康复研究。目前在癌症检测、粒细胞抗癌免疫治疗、营养抗癌等方向已取得突破性进展。部分科研项目已进入临床转化阶段，是致慧医疗科技（上海）有限公司创始人。
作为项目负责人承担十余项国家及省部级科研项目，包括国家自然科学基金面上项目、教育部博士点基金、上海市科委生物医药科技支撑项目、上海市卫健委优青计划等。迄今在Adv. Mater.、ACS Nano、Theranostics等国际知名学术期刊发表SCI论文60 余篇，总引用次数超过3000多次（H因子23），申请国家发明专利 30 余项，已授权 10余项。
荣获上海市卫健委优秀青年医学人才，同济大学“青年岗位能手”，福建省“百人计划”专家，台州“500精英计划”A类人才等称号。兼任白求恩精神研究会检验医学分会理事、中国抗癌协会肿瘤标志物委员会CTC专家委员会委员、上海市医师协会肿瘤精准诊疗专业委员会委员、中国人体健康科技促进会临床检验科学技术转化专业委员会常委、全国卫生产业企业管理协会转化医学专家委员会委员、全国抗衰老协会肿瘤风险评估与系统康复专委会委员，国家自然科学基金评审专家，教育部学位论文评审专家等。
【代表性论文】
1. Xiao Y, Chen K, Hu T, Wang Y, Wang J, Lv C, Xu J, Zhang X, Li A, Chen B* . A bionic “trojan horse”-like nanovesicle delivery system hybridized with BCG cytoplasmic membrane and melanoma cell membrane for cancer immunotherapy[J]. Pharmaceutics, 2025, 17(4): 507.
2. Du Y, Wang Y, Kong M, Liang T, Long Q, Chen B*, Zhu Q. Confidence calibration for multimodal LLMs: an empirical study through medical VQA, MICCAI, 2025[J].
3. Lin C, Wang J, Zhu Y, Zhang D, Huang X, Wang J, Ren J, Hou M, Wu M, Shen B, Chen B*. Enhancing cancer-killing activity of PMN transfusion therapy via apoptotic modulation function of selenium nanoparticles[J]. Chemical Engineering Journal, 2025, 514: 162764.
4. Ninghan Fan, Ming Kong, Jing Huang, Qiang Zhu, Bingdi Chen*. Explainable ADHD diagnostic framework using weakly-supervised action recognition, MICCAI,2025[J].
5. Wang, Jiaming, Mingchong Liu, Chensong Yang, Xixi Huang, Chenyu Lin, Yuqian Zhu, Jing Wang, Hongyi Zhang, Bingdi Chen* and Guixin Sun. Photocrosslinked gelatin methacryloyl/hyaluronic acid methacryloyl composite hydrogels loaded with bone morphogenetic protein 2-black phosphorus nanosheets for bone regeneration[J]. Journal of Biomaterials Science, Polymer Edition, 2025, 36(14): 1962-1984.
6. Chen X, Chen B, Zhao H. Role of neutrophils in anti-tumor activity: characteristics and mechanisms of action[J]. Cancers, 2025, 17(8): 1298.
7. Shuyuan Hu, Jingyao Chen, Yihui Hu, Wenjun Le, Pengbo Zhang, Wenwen Jia, Quanhu Sun, Tao Chen, Wei Bao, Zheng Cui, Bingdi Chen*. The intensity of cell surface charge defines the malignancy of cancer cells[J]. Chemical Engineering Journal, 2025, 519: 164948.
8. Wenjun Le, Shuyuan Hu, Pengbo Zhang, Yanqi Wang, Yihui Hu, Zheng Cui, Bingdi Chen*. Capture of live circulating tumor cells via unique surface charges from cancer patients by a novel nanotechnology[J]. Interdisciplinary Medicine, 2024, 2(4): e20240045.
9. Jun Li , Jutang Li , Jingyao Chen , Wei Cao , Bingdi Chen*. Comprehensive analysis of ATP6V1s family member, ATP6V1C2, with prognostic and drug development values in colorectal cancer[J]. Pathology, Research and Practice, 2024, 258: 155357.
10. Gang Liu , Jinfeng Zhu , Pengbo Zhang , Tingting Zhang , Zheng Cui , Fanglei Jiao , Wenjun Le , Xiaofeng Li , Bingdi Chen*. Exploring the diagnostic and prognostic significance of circulating tumor cells in stage II-IV colorectal cancer using a nano-based detection method[J]. Journal of the Chinese Medical Association, 2024, 87(10): 945-952.
11. Yilong Huang, Shasha Shen, Jie Xiao, Cici Luo, Jiyao Ma, Xin Huang, Tianfu Qi, Chao Gao, Guiyun Li, Fan Li, Bo He, Bingdi Chen, Dan Han. Mesothelin-targeted MRI for assessing migration, invasion, and prognosis in malignant pleural mesothelioma[J]. Cancer Nanotechnology, 2024, 15(1) 1.
12. Wenjia Guo , Yu’e Liu , Bingdi Chen , Lieying Fan.Target prediction and potential application of dihydroartemisinin on hepatocarcinoma treatment[J]. Naunyn-Schmiedeberg’s Archives of Pharmacology, 2024, 397(10): 7711-7724.
13. Li X, Zheng J, Zhu J,Huang X, Zhu X ,Chen B* . Circulating tumor cells: biological features and survival mechanisms[J]. Biocell, 2023, 47(8): 1771-1781.
14. Qidong Wang, Meng Li, Tianming Cui, RuiWu, Fangfang Guo, Mei Fu, Yuqian Zhu, Chensong Yang, Bingdi Chen* and Guixin Sun*. A Novel Zwitterionic Hydrogel Incorporated with Graphene Oxide for Bone Tissue Engineering Synthesis Characterization and Promotion of Osteogenic Differentiation of Bone Mesenchymal Stem Cells. Int. J. Mol. Sci. 2023, 24, 2691
15. Yuqian Zhu, Jingyao Chen, Jun Li, Chenqi Zhou, Xin Huang*and Bingdi Chen*. Ginsenoside Rg1 as a promising adjuvant agent for enhancing the anti-cancer functions of granulocytes inhibited by noradrenaline. Frontiers in Immunology, 2023, 14:1070679.
16. Jingyao Chen#, Dan Li#, Chenqi Zhou, Yuqian Zhu, Chenyu Lin, Liting Guo, Wenjun Le, Zhengrong Gu* and Bingdi Chen*. Principle Superiority and Clinical Extensibility of 2D and 3D Charged Nanoprobe Detection Platform Based on Electrophysiological Characteristics of Circulating Tumor Cells. Cells 2023, 12, 305.
17. Jun Li#, Chenjie Qin#, Yicheng Wu, Sheng Cheng,Yuanqing Wang, Huijie Chen, Fangli Chen*, Bingdi Chen* and Jutang Li*. Targeting LRRC41 as a potential therapeutic approach for hepatocellular carcinoma. Frontiers in Molecular Biosciences, 10:1300294.
18. Jun Li#, Chenyu Lin#, Yuqian Zhu, Chengwei Shao, Tiegong Wang* and Bingdi Chen*. Colorectal cancer cell membrane biomimetic ferroferric oxide nanomaterials for homologous bio-imaging and chemotherapy application. Medical Oncology, 2023, 40:322.
19. Mei Fu, Jun Li, Mingchong Liu, Chensong Yang, Qidong Wang, Hongrui Wang, Bingdi Chen, Qingge Fu*, Guixin Sun*. Sericin/Nano-Hydroxyapatite Hydrogels Based on Graphene Oxide for Effective Bone Regeneration via Immunomodulation and Osteoinduction. International Journal of Nanomedicine, 2023:18 1875–1895.
20. Huixiao Yuan#, Xin Huang#, Qingqing Li#, Cici Luo, Chenyu Lin, Shuxian Zhang, Yaguang Zhang, Zhilin Yan, Ning Du, Zhongmin Liu*, Hua Jiang*, Bingdi Chen*. SiRNA-circFARSA-loaded porous silicon nanomaterials for pancreatic cancer treatment via inhibition of CircFARSA expression, Biomedicine & Pharmacotherapy, 2022, 147, 112672.
21. Jinshan Xu#, Shuxiong Zeng#, Jun Li#, Li Gao, Wenjun Le, Xin Huang, Guandan Wang, Bingdi Chen*, Zhengsheng Zhang*, Chuanliang Xu*. Novel Non Invasive Diagnosis of Bladder Cancer in Urine Based on Multifunctional Nanoparticles, Frontiers in Cell and Developmental Biology, 2022, 9, 813420.
22. Jing Wang, Wenjun Le, Tinghua Yan, Jinhua Jiang*, Bingdi Chen*. Usage of Nanoparticles to Alter Neutrophils’ Function for Therapy, ACS Biomaterials Science & Engineering, 2022, 8,3676
23. Yao Yao#; Jingyao Chen#; Yuhan Guo; Tian Lv; Zilin Chen; Ning Li; Shaokui Cao; Bingdi Chen*; Tao Chen*; Integration of interstitial fluid extraction and glucose detection in one device for wearable non-invasive blood glucose sensors, Biosensors and Bioelectronics, 2021, 179: 113078.
24. Xin Huang#, Chenyu Lin#, Cici Luo, Yuhan Guo, Jun Li, Yiping Wang, Jiahong Xu, Yuwen Zhang, He Wang*, Zhongmin Liu*, Bingdi Chen*. Fe3O4@M nanoparticles for MRI-targeted detection in the early lesions of atherosclerosis, Nanomedicine: Nanotechnology, Biology, and Medicine, 2021, 33, 102348.
25. Jing Wang#, Tianxiao Mei#, Yang Liu, Yifan Zhang, Ziliang Zhang, Yihui Hu, Yibin Wang, Minliang Wu, Chuanxue Yang, Xiangdong Zhong, Bingdi Chen*, Zheng Cui, Wenjun Le*, Zhongmin Liu*. Dual-targeted and MRI-guided photothermal therapy via iron-based nanoparticles-incorporated neutrophils, Biomaterials Science, 2021, 9, 3968.
26. Chen, Xin#; Wang, Tiegong#; Le, Wenjun; Huang, Xin; Gao, Minghui; Chen, Qian; Xu，Shuogui; Yin, Detao; Fu, Qingge; Shao, Chengwei; Bingdi Chen*; Shi, Donglu; Smart Sorting of Tumor Phenotype with Versatile Fluorescent Ag Nanoclusters by Sensing Specific Reactive Oxygen Species, Theranostics, 2020, 10(8): 3430.
27. M. L. Wu, T. X. Tian, C. Y. Lin, Y. C. Wang, J. Y. Chen, W. J. Le*, M. Y. Sun, J. G. Xu, H. Y. Dai, Y. F. Zhang, C. Y. Xue*, Z. M. Liu, B. D. Chen*, Melanoma Cell Membrane Biomimetic Versatile CuS Nanoprobes for Homologous Targeting Photoacoustic Imaging and Photothermal Chemotherapy, ACS Applied Materials & Interfaces, 2020, 1214:16031
28. M. L. Wu, W. J. Le, T. X. Mei, Y. C. Wang, B. D. Chen*, Z. M. Liu, C. Y. Xue*, Cell membrane camouflaged nanoparticles: a new biomimetic platform for cancer photothermal therapy. International Journal of Nanomedicine 2019, 14:4431-4448
29. X. Huang, W. J. Le, Q. Chen, J. Y. Chen, Y. Q. Zhu, D. L. Shi, B. D. Chen*, Z. Cui*, Suppression of the innate cancer-killing activity in human granulocytes by stress reaction as a possible mechanism for affecting cancer development. Stress 2019, DOI: 10.1080/10253890. 2019.1645112.
30. W. J. Le, B. D. Chen, Z. Cui, Z. M. Liu*, D. L. Shi*, Detection of cancer cells based on glycolytic-regulated surface electrical charges. Biophysics Reports 2019,5, 1:10-18
31. H. H. Zhu, X.F. Li, J.F.Zhu, X.Huang, Q. He, B. D. Chen, W.Cao, Circulating tumor cells detected by surface-enhanced Raman scattering technique based on graphene oxide/gold nanorods. Journal of the Second Military Medical University, 2019, 40(6): 643-650.
32. B. D. Chen, W. J. Le, Y. L. Wang, Z. Q. Li, D. Wang, L. Lin, S. B. Cui, J. J. Hu, Y. H. Hu, P. Y.Yang, R. C. Ewing, D. L. Shi*, Z. Cui* Targeting Negative Surface Charges of Cancer Cells by Multifunctional Nanoprobes. Theranostics 2016, 6, 11:1887-1898
