学术成果
以第一作者或通讯作者在国际知名学术期刊Advanced Materials, Advanced Functional Materials, Advanced Science, Ebiomedicine, Theranostics, ACS Applied Materials & Interfaces, ACTA Biomaterialia, Journal of Colloid&Interface Science, Nanoscale, Chemical Communication, Langmuir上发表SCI收录论文30余篇,署名SCI论文51篇,总影响因子约为330,论文总引用次数2100余次,单篇最高引用270余次;2篇ESI高被引论文,6篇引用次数过百,h-index:24。申请发明专利15项,拥有授权发明专利8项(其中第一发明人6项),已实现专利权转让3项。
承担项目
[1] 国家自然科学基金面上项目“纳米酶携载乙酯利血平抑制乳酸外排协同增效肿瘤催化治疗与免疫微环境重塑”(32271439);项目起止年月:2023年01月至2026年12月;(在研)
[2] 国家自然科学基金面上项目“颗粒-蛋白相互作用分子机制及代谢重编程敏感的循环肿瘤细胞捕获方法研究”(32071395);项目起止年月:2021年01月至 2024年 12月;(在研)
[3] 国家自然科学基金面上项目“基于人源性组织异种移植瘤(PDTX)模型的新型miRNA纳米载体构建及其治疗效应研究”(31571018);项目起止时间:2016年01月至2019年12月; (已结题)
[4] 上海市科委“科技创新行动计划”生物医药领域科技支撑项目“前列腺癌血清标记物free PSA/total PSA联合检测的磁性免疫层析试剂盒样品的试制”(15441905900);项目起止时间:2015年07月至2019年09月; (已结题)
[5] 上海市自然科学基金项目“miRNA-介孔Fe3O4纳米晶簇新型复合系统的构建及其对头颈鳞癌细胞生长抑制效应的研究”(15ZR1443200);项目起止时间:2015年01月至2017年12月;(已结题)
[6] 上海市科委引导项目“结核杆菌纳米探针检测新方法研究”(124119a1500);项目起止时间:2012年10月至2015年09月;共同主持; (已结题)
[7] 国家自然科学基金青年基金项目“含双功能基团无机/有机非对称纳米磁性复合材料的可控制备”(51003077);项目起止时间:2011年01月至2013年12月;(已结题)
[8] 中央高校基本科研项目“石墨烯/磁性复合纳米材料合成及水处理应用研究”;项目起止时间:2012年01月至2013年12月;(已结题)
[9] 污染控制与资源化研究国家重点实验开放课题“石墨烯-磁性纳米材料的制备及其对典型重金属的去除研究”(PCRRF11003);项目起止时间:2011年09月至2012年12月;(已结题)
[10] 同济大学青年优秀教师项目“非对称形貌及表面功能化的无机/聚合物磁性复合微球的可控制备”(2009KJ074);项目起止时间:2010年09月至2013年12月;(已结题)
学术兼职
中国微米纳米学会高级会员、中国化学会会员 、《生物医学工程学杂志》青年编委。国家自然科学基金面上和青年项目函评专家、教育部博硕士学位论文盲审专家、教育部高等学校科学研究发展中心评审专家、上海市科委“科技创新行动计划”项目评审专家等;
同时担任Nature Communications, Advanced Materials, Advanced Functional Materials, Biomaterials, Nano Letters, Chemical Engineering Journal, Small, Nanoscale, Chemical Communications, Langmuir, Journal of Harzard Materials, Journal of Polymer Science,Part A等国际学术期刊审稿专家。
学术会议、学术交流
2024.04 全国磁性材料与器件大会/生物医用磁性纳米材料专题委员,口头报告
2023.04 中国微米纳米技术学会第六届微米纳米技术应用创新大会,口头报告
2021.05 中国微米纳米技术学会第五届微米纳米技术应用创新大会,口头报告
2019.12 中国微米纳米技术学会第三届微流控技术应用创新论坛,口头报告
2018.05 中国微米纳米技术学会第二届微米纳米技术应用创新大会,口头报告
2017.07 再生医药生物材料及生物制造国际会议(南京),口头报告
2016.12 国际纳米生物与医学学术会议(福州),口头报告
2013.09第十四届全国生物材料大会,口头报告
教育背景
2003.09-2009.06 博士 应用化学专业 上海交通大学 (硕博联读)
2007.09-2008.09 博士联合培养美国西雅图华盛顿大学(CSC公派研究生项目)
1994.09-1998.07 学士 高分子材料专业 青岛科技大学
工作经历
2022.12至今 同济大学医学院 “生物材料与诊疗技术”课题组长(PI)
2021.12至今 同济大学医学院 研究员(自然科学类正高),博士生导师
2020.05 至今 同济大学附属东方医院 转化医学中心双聘课题组长(PI)
2013.12-2021.12 同济大学医学院 副研究员,博士生导师
2009.07-2013.11 同济大学 先进材料与纳米生物医学研究院 讲师
1998.07-2003.08 重庆庆兰实业有限公司 生产技术设备部 工艺主管
教学情况
研究生专业选修课《纳米材料与生物医学检测》(2015~至今)
医学院本科生(国豪班)交叉创新课程《生物材料与组织工程》(2024~)
同济大学本科生通识课《纳米科学与艺术》(2011-2013)
代表性论文
Lehua Xu#, Chenlong He#, Shusheng Yang#, Yunxia Zhu, Peng Wang, Shengming Wu, Fangfang Guo, Yilong Wang*, Phase-transited lysozyme nanofilm with coimmobilized copper ion and heparin as cardiovascular stent multifunctional coating, Colloids and Surfaces B: Biointerfaces, 2023, 230, 113530. (#Co-first author)
Shengming Wu, Lehua Xu, Chenlong He, Peng Wang, Jingwen Qin, Fangfang Guo, Yilong Wang*, Lactate effluxinhibition bysyrosingopine/LOD co-loaded nanozyme for synergetic self-replenishing catalytic cancer therapy and immune microenvironment remodeling, Advanced Science, 2023, 2300686.
Meng Li, Shengming Wu, Chengle Zhuang, Chenzhang Shi, Lei Gu, Peng Wang, Fangfang Guo, Yilong Wang*, Zhongchen Liu*, "Metabolomic Analysis of Circulating Tumor Cells Derived Liver Metastasis of Colorectal Cancer", HELIYON, 2023, 9, e12515.
Yawen Ma#, Huimin Lin#, Peng Wang#, Haocheng Yang, Jie Yu, Hao Tian, Tianyu Li, Shengfang Ge, Yilong Wang*, Renbing Jia*, Kam W. Leong, Jing Ruan*, A miRNA-based gene therapy nanodrug synergistically enhances pro-inflammatory antitumor immunity against melanoma, ACTA Biomaterialia, 2023, 155, 538–553.(#Co-first author)
Zicheng Deng, Shengming Wu, Yilong Wang*, Donglu Shi*, Circulating Tumor Cell Isolation for Cancer Diagnosis and Prognosis, EBioMedicine, 2022, 83, 104237. (invited review article, * Co-Corresponding author )
Yanbai Pei, Shengming Wu, Peng Wang, Jingwen Qin, Lehua Xu, Yilong Wang*, "Path-Dependent Anisotropic Colloidal Assembly of Magnetic Nanocomposite-Protein Complexes", Langmuir, 2022, 38, 20, 6265–6272.
Peng Wang#, Junli Xue#, Shengming Wu, Yanbai Pei, Lehua Xu, Yilong Wang*, "Cell-Friendly Isolation and pH Sensitive Controllable Release of Circulating TumorCells by Fe3O4@CaCO3 Nanoplatform", Advanced Materials Interfaces, 2021, 2101191. (#Co-first author)
Shengming Wu, Peng Wang, Jingwen Qin, Yanbai Pei, Yilong Wang*,"GSH-Depleted Nanozymes with Dual-Radicals Enzyme Activities for Tumor Synergic Therapy" , Advanced Functional Materials, 2021, 2102160.
Shengming Wu#, Lei Gu#, Jingwen Qin, Lei Zhang, Yishu He, Jian Zhao, Fenyong Sun*, Zhongchen Liu*, Yilong Wang*, Rapid Label-free Isolation of Circulating Tumor Cells from Patients Peripheral Blood using Positively-charged Fe3O4 Nanoparticles,ACS Appl. Mater. Interfaces, 2020, 12, 4193-4203. (#Co-first author, * Co-Corresponding author)
Yishu He, Jingwen Qin, Shengming Wu, Haocheng Yang, Huiyun Wen*, Yilong Wang*, Cancer Cell-Nanomaterial Interface: Role of Geometry and Surface Charge of Nanocomposites on the Capture Efficiency and Cell Viability, Biomaterials Science,2019,DOI: 10.1039/c9bm00037b
Yilong Wang#,*, Xiao Han#, Zheng Cui*, Donglu Shi*, Bioelectricity, Its Fundamentals, Characterization Methodology, and Applications in Nano-Bioprobing and Cancer Diagnosis, Advanced Biosystems, 2019, 1900101, DOI: 10.1002/adbi.201900101. (review article, # Co-first author, * Co-Corresponding author )
Wei Tian, Fan Li, Shengming Wu, Gen Li, Lieying Fan, Xue Qu*, Xinming Jia*, Yilong Wang*, Efficient Capture and T2 Magnetic Resonance Assay of Candida albicans with Inorganic Nanoparticles: Role of Nanoparticle Surface Charge and Fungal Cell Wall, ACS Biomaterials Science & Engineering, 2019, DOI:10.1021/acsbiomaterials.9b00069. (* Co-Corresponding author )
Yilong Wang#; Shuyang Sun#; Zhiyuan Zhang, Donglu Shi, Nanomaterials for Cancer Precision Medicine, Advanced Materials, 2018, 30,(17): 1705660. DOI: 10.1002/adma.201705660 (# Co-first author, review article)
Chang Xu, Qishuai Feng, Haocheng Yang, Guangxue Wang, Liqun Huang, Qianwen Bai,Chuyi Zhang, Yilong Wang*, Yingna Chen, Qian Cheng, Yu Han, Zuoren Yu*, Maciej S. Lesniak, Yu Cheng*, A Light-Triggered Mesenchymal Stem Cell Delivery System for Photoacoustic Imaging and Chemo-Photothermal Therapy of Triple Negative Breast Cancer, Advanced Science, 2018, 5, 1800382. (* Co-Corresponding author )
Jian Zhao#,*, Shengming Wu#, Jingwen Qin, Donglu Shi*, and Yilong Wang*, Electrical-Charge-Mediated Cancer Cell Targeting via Protein Corona-Decorated Superparamagnetic Nanoparticles in a Simulated Physiological Environment, ACS Appl. Mater. Interfaces, 2018, 10, 41986-41998. (# Co-first author, * Co-Corresponding author )
Xiao Han; Zicheng Deng; Zi Yang; Huanhuan Zhu; Bingdi Chen; Yilong Wang*; Zheng Cui; Rodney C. Ewing; Donglu Shi*, Biomarkerless targeting and photothermal cancer cell killing by surface-electrically-charged superparamagnetic Fe3O4 composite nanoparticles, Nanoscale,2017, 9, 1457~1465. (Back cover article, * Co-Corresponding author )
Shuyang Sun#; Yilong Wang#; Rong Zhou; Zicheng Deng; Yong Han; Xiao Han; Wenjie Tao; Zi Yang; Chaoji Shi; Duo Hong; Jiang Li; Donglu Shi*; Zhiyuan Zhang*, Targeting and Regulating of an Oncogene via Nanovector Delivery of MicroRNA using Patient-Derived Xenografts, Theranostics, 2017, 7, 677~693. (# Co-first author, * Co-Corresponding author,Front cover article)
Du, Juan; Zhao, Yong; Yang, Zi; Xu, Changhua; Lu, Ying*; Pan, Yingjie; Shi, Donglu; Wang, Yilong*, Influence of controlled surface functionalization of magnetic nanocomposites on the detection performance of immunochromatographic test, Sensors and Actuators B: Chemical, 2016, 237, 817~825. (* Co-Corresponding author )
Han, Xiao; Huang, Shiming; Wang, Yilong*; Shi, Donglu*, Design and development of anisotropic inorganic/polystyrene nanocomposites by surface modification of zinc oxide nanoparticles, Materials Science and Engineering: C, 2016, 64, 87~92. (* Co-Corresponding author )
Bingdi Chen#, Wenjun Le#, Yilong Wang, Zhuoquan Li, Dong Wang, Lei Ren, Ling Lin, Shaobin Cui,Jennifer J. Hu, Yihui Hu, Pengyuan Yang, Rodney C. Ewing, Donglu Shi* ,Zheng Cui*, Targeting Negative Surface Charges of Cancer Cells by Multifunctional Nanoprobes, Theranostics, 2016, 6(11): 1887-1898. (#Co-first author, * Co-Corresponding author )
Tian Li, Xiao Han, Yilong Wang*, Feng Wang, Donglu Shi, Preparation of Spherical Caged Superparamagnetic Nanocomposites with Completed Inorganic Shell via a Modified Miniemulsion Technology, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2015, 477, 84-89.
Hua Yang, Hui Ma, Yilong Wang*, Bingbo Zhang, Lianhua Qin, Zhonghua Liu, Junmei Lu, Xiaochen Huang, Jie Wang, Donglu Shi, Zhongyi Hu*,Detection of Mycobacterium Tuberculosis based on H37Rv binding peptides using surface functionalized magnetic microspheres coupled with quantum dots, International Journal of nanomedicine, e, 2015,10:77-88. (* Co-Corresponding author )
Jun Yan, Yingying Liu, Yilong Wang,* Xiaowei Xu, Ying Lu,* Yingjie Pan,Fangfang Guo, Donglu Shi, Effect of Physiochemical Property of Fe3O4 Particle on Magnetic Lateral Flow Immunochromatographic Assay, Sensors & Actuators: B. Chemical, 2014, 197, 129-136. (* Co-Corresponding author )
Feng Wang, Giovanni M. Pauletti, Juntao Wang, Jiaming Zhang, Rodney C. Ewing, Yilong Wang* and Donglu Shi*, Dual Surface-functionalized Janus Nanocomposites of Polystyrene/Fe3O4@SiO2 for Simultaneous Tumor Cell Targeting and Stimulus-induced Drug Release, Advanced Materials, 2013, 25, 3485–3489. (* Co-Corresponding author )
Tian Li,Yilong Wang*,Fangfang Guo,Donglu Shi,Synthesis and Biomedical Applications of Magnetic Nanocomposites with Complex Morphologies, Progress In Chemistry, In press, 2013.
Yulin Tang, Hongguang Guo, Lan Xiao, Naiyun Gao, Shuili Yu, Yilong Wang*, Adsorption behavior and mechanisms of fluoroquinolone antibiotics on the reduced graphene oxide/magnetite composites, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2013, 424, 74– 80.
Yilong Wang, Song Liang, Bingdi Chen, Fangfang Guo, Shuili Yu, Yulin Tang*, Synergistic removal of Pb(II), Cd(II) and humic acid by Fe3O4@mesoporous silica-graphene oxide composites, PLoS One, 2013, 8, e65634:1-8.
Yulin Tang*, Song Liang, Juntao Wang, Shuili Yu, Yilong Wang*, Amino functionalized core-shell magnetic mesoporous composite microspheres for Pb(II) and Cd(II) removal, Journal of Environmental Sciences, 2013, 25, 830-837. (* Co-Corresponding author )
Fangyingkai Wang, Yulin Tang, Bingbo Zhang, Bingdi Chen, Yilong Wang*, Preparation of Novel Magnetic Hollow Mesoporous Silica Microspheres and their Efficient Adsorption, Journal of Colloid & Interface Science 2012, 386, 129-134.
Yulin Tang*, Song Liang, Shuili Yu, Naiyun Gao, Jun Zhang, Haicheng Guo, Yilong Wang*, Enhanced adsorption of humic acid on amine functionalized magnetic mesoporous composite microspheres, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2012, 406, 61- 67. (* Co-Corresponding author )
Yilong Wang*, Fangyingkai Wang, Bingdi Chen, Hong Xu*, Donglu Shi. “Facile one-pot synthesis of yolk–shell superparamagnetic nanocomposites via ternary phase separations” Chemical Communications, 2011, 47, 10350 - 10352. (* Co-Corresponding author )
Yilong Wang*, Hong Xu, Yongsheng Ma, Fangfang Guo, Feng Wang, and Donglu Shi*. “Facile One-Pot Synthesis and Morphological Control of Asymmetric Superparamagnetic Composite Nanoparticles” Langmuir, 2011, 27, pp 7207–7212. (* Co-Corresponding author )
Yilong Wang, Hong Xu, Weili Qiang, Hongchen Gu, and Donglu Shi, “Asymmetric Composite Nanoparticles with Anisotropic Surface Functionalities”,Journal of Nanomaterials, 2009, 620269, 1-5
Yilong Wang, Hong Xu, and Hongchen Gu*, Synthesis of Raspberry-Like SiO2/Polystyrene Nanocomposite Particles via Miniemulsion Polymerization, Journal of Nanoscience and Nanotechnology, 2009, 9, 1571-1576.
Yilong Wang, Pedro H. C. Camargo, Sara E. Skrabalak, Hongchen Gu, and Younan Xia*, “A Facile, Water-Based Synthesis of Highly Branched Nanostructures of Silver”,Langmuir, 2008, 24, 12042-12046.
Weili Qiang#, Yilong Wang#, Ping He, Hong Xu*, Hongchen Gu, and Donglu Shi, “Synthesis of Asymmetric Inorganic/Polymer Nanocomposite Particles via Localized Substrate Surface Modification and Miniemulsion Polymerization”, Langmuir, 2008, 24, 606-608. (#co-first author, * Co-Corresponding author)
已授权中国发明专利
[1] 一种磁性荧光双功能氧化硅空心微球的制备方法,王祎龙;马方;陈炳地;张兵波;郭方方;时东陆;专利号:ZL 2011 1 0132719.7;
[2] 具有核壳结构及表面各向异性双功能团的磁性二氧化硅微球及其制备方法,王祎龙;张兵波;郭方方;时东陆;专利号:ZL 2011 1 0029024.6;
[3] 一种壳层中包埋磁性纳米颗粒的介孔氧化硅空心微球的制备方法,王祎龙;唐玉霖;王方英凯;专利号:ZL 201110344263.0;
[4] 具有非对称结构及表面各向异性双功能基团的磁性氧化硅聚合物复合微球的制备方法,王祎龙;时东陆;专利号:ZL 201310182495.X;
[5] 一种蛋黄-蛋壳结构的氧化锌三元复合纳米材料及其制备方法,王祎龙,韩筱,时东陆,申请号:201410253569.9,申请日期:2014.6.10,授权公告日:2016.4.20,专利号:ZL 201410253569.9
[6] 一种由两种高分子共修饰的生物相容性磁性微球及其制备方法,王祎龙,李恬,韩筱,时东陆,申请号:201410305539.8,申请日期:2014.7.1,授权公告日:2016.6.15,专利号:ZL 201410305539.8
[7] 一种磁性纳米复合材料的制备方法、由该方法制备的产品及其应用,唐玉霖;王祎龙;于水利; 专利号:ZL 2011 1 0407318.8;
[8] 一种高性能锂离子电池负极材料石墨烯负载纳米氧化亚钴的制备方法,陈炳地;郭方方;王祎龙;张兵波;时东陆;专利号:ZL 2011 1 0443045.2;
学生培养
独立指导博士毕业生2人、硕士毕业生10人,联合指导博士毕业生1人、硕士毕业生10人(包括同济大学材料学院、环境学院等、附属肺科医院、附属第十人民医院,上海海洋大学、华东理工大学、西北大学、青岛科技大学等高校研究生);
目前在读博士研究生1名和硕士研究生3名,另外有2名博士研究生进行联合培养;
指导学生获得上海市优秀毕业生、博士生新生奖学金、校级优秀博士生奖学金、优秀社会活动奖学金等称号;本人获得2019级优秀新生导师称号。
部分毕业生进入美敦力、GE医药、强生、联影医疗等从事专业技术工作;1人于2023年获得美国辛辛那提大学博士学位(与辛辛那提儿童医院联合培养),现在弗吉尼亚理工开展博士后工作。
热烈欢迎具有生物医学工程、细胞生物学、生物技术、高分子材料、无机材料、生物力学等专业背景和科研经历,希望致力于纳米医学、生物材料、材料-生物表界面等基础研究,或基于磁性纳米材料的诊疗技术应用基础研究的优秀同学报考同济大学医学院学术型研究生和“生物与医药”专业学位研究生!!!