转录调控的结构与功能研究，以结构为基础的药物设计

Structural and functional studies of transcription regulation, structure-based drug design

2022.03-至今 同济大学医学院 助理教授

2021.07-2022.02 清华大学医学院 研究助理

2016.09-2021.06 清华大学 博士（导师饶子和院士）

郑礼涛助理教授毕业于清华大学，师承著名结构生物学家饶子和院士。主要从事RNA转录过程的分子机制研究。相关研究成果以共同第一作者或者其他作者身份在国际著名期刊 Cell（2篇）、Science 、Nature communication、 Nucleic Acids Res等发表多篇原创性论文。共同一作Cell论文入选2021年度“中国百篇最具影响国际学术论文”和“中国2021年度重要医学进展”。病毒RNA转录研究成果入选2021年度“中国科技十大进展”和“中国生命科学十大进展”。入选上海市科委杨帆计划。主持主持上海市科委，上海市卫健委和同济大学自主原创项目共3项。此外，还参与包括科技部重大项等在内的多个项目的研究。

已发表的论文：

1、Yan Liming*, Ge Ji*, Zheng Litao*, Zhang Ying, Gao Yan, Wang Tao, Huang Yucen, Yang Yunxiang, Gao Shan, Li Mingyu, Liu Zhenyu,Wang haofeng, Li Yingjian, Chen Yu, Guddat Luke W, Wang Quan, Rao Zihe#, Lou Zhiyong#. Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Cell,2021.184(1): 184-193.共同第一作者

2、Yan Liming*, Yang Yunxiang*, Li Mingyu*, Zhang Ying*, Zheng Litao*, Ge Ji*, Huang Yucen C*, Liu Zhenyu*, Wang Tao, Gao Shan, Zhang Ran, Huang Yuanyun Y, Guddat Luke W, Gao Yan#, Rao Zihe#, Lou Zhiyong#. Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3’-5’ exoribonuclease with polymerase reveals mechanisms for mRNA capping and proofreading. Cell,2021.184(13): 3474-3485.共同第一作者

3、Yan Liming*, Zhang Ying*, Ge Ji, Zheng Litao, Gao Yan, Wang Tao, Jia Zhi, Wang Haofeng, Huang Yucen, Li Mingyu, Wang Quan, Rao Zihe#, Lou Zhiyong#. Architecture of a SARS-CoV-2 mini replication and transcription complex. Nature Communications,2020. 11(1): 5874.

4、Gao Yan*, Yan Liming*, Huang Yucen*, Liu Fengjiang*, Zhao Yao, Cao Lin, Wang Tao, Sun Qianqian, Ming Zhenhua, Zhang Lianqi, Ge Ji, Zheng Litao, Zhang Ying, Wang Haofeng, Zhu Yan, Zhu Chen, Hu Tianyu, Hua Tian, Zhang Bing, Yang Xiuna, Li Jun, Yang Haitao, Liu Zhijie, Xu Wenqing, Guddat Luke W, Wang Quan, Lou Zhiyong#, Rao Zihe#. (2020). Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science,2020. 368(6492): 779-782.

5、Jia Zhihui*, Yan Liming*, Ren Zhilin, Wu Lijie, Wang Jin, Guo Jing, Zheng Litao, Ming Zhenhua, Zhang Lianqi, Lou Zhiyong, Rao Zihe#. Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis. Nucleic Acids Resarch,2019.47(12): 6538-6550.