【承担课题】
1. 国家自然科学基金：GMFB调控星形胶质细胞CARM1/PPARG通路改善损伤轴突再髓鞘化的机制研究（82471073）
2.中央高校研究基金：胶质细胞成熟因子beta 控制视神经损伤后内源性干细胞动员的微环境（22120220009）
3.上海市自然科学基金:胶质成熟因子beta在早期糖尿病视网膜病变的作用机制及干预策略研究（17ZR1431300）
4.上海卫健委 (201640229) GMFB作为糖尿病视网膜病变早期神经变性标记物的研究
【Projects】
1.National Natural Science Foundation of China: Mechanism study of GMFB regulating CARM1/PPARG pathway in astrocytes to improve remyelination of injured axons (82471073)
2.Fundamental Research Funds for the Central Universities: Glial maturation factor beta controls the microenvironment for endogenous stem cell mobilization after optic nerve injury (22120220009)
3.Shanghai Natural Science Foundation: Study on the mechanism and intervention strategy of glial maturation factor beta in early diabetic retinopathy (17ZR1431300)
4.Shanghai Municipal Health Commission Project (201640229): GMFB as an early neurodegenerative marker for diabetic retinopathy
【发表文章】
1.Xu J, Zhu L, Li J, Xu J, Cui T, Jia S, Zhu T, Shi S, Gao F, Jin C, Tian H, Wang J, Ou Q, Xu JY, Bi YL, Xu GT, Zhang X, Lu L*. Glia maturation factor-beta deficiency improves insulin resistance by promoting CARM1-mediated lipid turnover. Pharmacol Res. 2025 Aug 30:107937. doi: 10.1016/j.phrs.2025.107937. Online ahead of print.PMID: 40889622
2.Liu C, Gao F, Zhu L, Sun W, Zhu T, Shi S, Wang J, Ou Q, Xu JY, Li J, Xu J, Jia S, Bi Y, Jin C, Tian H, Xu GT, Lu L*.Extracellular GMFB activates the non-canonical FAS-FAF1 pathway to induce lysosomal dysfunction in early diabetic retinopathy.Int J Biol Macromol. 2025 Jun 7;318(Pt 1):145082. doi: 10.1016/j.ijbiomac.2025.145082. PMID: 40490177
3.Chen Z, Zhu X, Lu M, Ou Q, Xueying Wang 1, Zhao Z, Shen Q, Wang Q, WangZ , Xu J, Jin C, Gao F, Wang J, Zhang J,Zhang J, Jin X, Bi Y,Lu L*, Xu G, Tian H. PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species. Adv Sci (Weinh) . 2025 May 21:e2505359. doi: 10.1002/advs.202505359.
4.Xu J, Huang Z, Shi S, Xia J, Chen G, Zhou K, Zhang Y, Bian C, Shen Y, Yin X*, Lu L*, Gu H*.Glial maturation factor-β deficiency prevents oestrogen deficiency-induced bone loss by remodelling the actin network to suppress adipogenesis of bone marrow mesenchymal stem cells.Cell Death Dis. 2024 Nov 14;15(11):829. doi: 10.1038/s41419-024-07234-z. （共通讯）
5.Sun W, Wang J, Liu C, Gao F, Ou Q, Tian H, Xu J, Zhang J, Li J, Xu J, Jia S, Zhang J, Xu G, Huang J, Jin C, Lu L*. SUMOylation of GMFB regulates its stability and function in retinal pigment epithelial cells under hyperglycemia. Int J Biol Macromol. 2024;268(Pt2):131678. doi: 10.1016/j.ijbiomac.2024.131678.
6.Zhu T, Li Y, Zhu L, Xu J, Feng Z, Chen H, Shi S, Liu C, Ou Q, Gao F, Zhang J, Jin C, Xu J, Li J, Zhang J, Bi Y, Xu GT, Wang J, Tian H, Lu L*.GMFB/AKT/TGF-β3 in Müller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model.Glia. 2024 Mar;72(3):504-528. doi: 10.1002/glia.24486.
7.Gao F, Li M, Zhu L, Li J, Xu J, Jia S, Ou Q, Jin C, Tian H, Wang J, Xu J, Xu W, Xu GT, Lu L.Knockdown of HSPA13 Inhibits TGFβ1-Induced Epithelial-Mesenchymal Transition of RPE by Suppressing the PI3K/Akt Signaling Pathway.Invest Ophthalmol Vis Sci. 2024 Sep 3;65(11):1. doi: 10.1167/iovs.65.11.1.
8.Xu J, Zhu L, Xu J, Lin K, Wang J, Bi YL, Xu GT, Tian H, Gao F, Jin C, Lu L*. The identification of a novel shared therapeutic target and drug across all insulin-sensitive tissues under insulin resistance. Front Nutr. 2024 Mar 26;11:1381779. doi: 10.3389/fnut.2024.1381779. eCollection 2024.
9.Shi S, Gu H, Xu J, Sun W, Liu C, Zhu T, Wang J, Gao F, Zhang J, Ou Q, Jin C, Xu J, Chen H, Li J, Xu G, Tian H, Lu L. Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity. Exp Mol Med. 2023 ;55(5):898-909. doi: 10.1038/s12276-023-00980-8.
10.Liu C, Sun W, Zhu T, Shi S, Zhang J, Wang J, Gao F, Ou Q, Jin C, Li J, Xu JY, Zhang J, Tian H, Xu GT, Lu L.Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.Redox Biol. 2022 Jun;52:102292. doi: 10.1016/j.redox.2022.102292. Epub 2022 Mar 18.
