主要从事微生物感染与神经免疫相关研究，重点关注白念珠菌感染的免疫识别及应答机制，探讨白念珠菌、牙龈卟啉单胞菌和隐球菌等微生物对神经系统的影响机制。相关研究成果以第一作者或通讯作者身份发表在在Nature Communications、Cell Host & Microbe、Trends in Microbiology、Proceedings of the National Academy of Sciences (PNAS)等杂志。作为项目负责人，承担国家自然科学基金、上海市科委项目等科研项目。
I specialize in research at the intersection of microbial infections and neuroimmunology, with a particular emphasis on the immune recognition and response mechanisms associated with Candida albicans infections. My work also explores the impact of microorganisms such as Candida albicans, Porphyromonas gingivalis, and Cryptococcus on the nervous system. I have published findings as the first or corresponding author in journals including Nature Communications, Cell Host & Microbe, Trends in Microbiology, and Proceedings of the National Academy of Sciences (PNAS). As the project leader, I have undertaken research projects funded by the National Natural Science Foundation of China and the Science and Technology Commission of Shanghai.
代表性论文：
Representative publications：
Yi-Heng Yang, Ke-Fang Xie, Shuai Yang, Huan Wang, Hui-Hui Ma, Min Zhou, Zhong-Wei Wang, Yebo Gu*, Xin-Ming Jia*. BLNK negatively regulates C-type lectin receptor-mediated antifungal immunity through inhibiting macrophage migration. PNAS 2024; (*Corresponding author, In press)
Fan Li, Hui Wang, Yan-Qi Li, Yebo Gu*, Xin-Ming Jia*. C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity. Nature Communications 2023; 14(1): 6718. (*Corresponding author, Featured article at Nature Communications)
Yebo Gu#, Xin-Ming Jia*. STING negatively regulates antifungal immunity. Trends in Microbiology 2023; 31(11): 1090-1092.
Yebo Gu#, Xin-Ming Jia*. Stealth strategies of Candida albicans to evade host immunity. Cell Host & Microbe 2024 Sep 11;32(9):1459-1461.
Yebo Gu#, Zhou Wu, Fan Zeng, Muzhou Jiang, Jessica L Teeling, Junjun Ni, Ichiro Takahashi. Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis Induces Bone Loss-Correlated Alzheimer's Disease-Like Pathologies in Middle-Aged Mice. Journal of Alzheimer’s Disease 2020; 78(1):61-74.
Wang Y, Zhao J, Gu Y#, Wang H, Jiang M, Zhao S, Qing H, Ni J. Cathepsin H: Molecular characteristics and clues to function and mechanism. Biochem Pharmacol. 2023 Jun;212:115585. doi: 10.1016/j.bcp.2023.115585. Epub 2023 May 5. PMID: 37148981.
科研项目：
国家自然科学基金, 青年科学基金项目（2025.01-2027.12）,主持，30万元
上海市科委, “科技创新行动计划”启明星项目（扬帆专项）（2022.05-2025.04）,主持，20万元
科技部, 国家重点研发计划“国家质量基础设施体系”重点专项（2023.11-2028.10），课题骨干，55万元
科技部, 国家重点研发计划“病原学与防疫技术体系研究”重点专项（2022.12-2025.11）, 课题骨干, 32万元
同济大学自主原创基础研究项目(2024.04-2026.03), 主持，12万元
Research projects:
Grants from the National Natural Science Foundation of China;
Grants from the Shanghai Sailing Program, the Science and Technology Commission of Shanghai;
Grants from Ministry of Science and Technology, National Key Research and Development Program of China, “National Quality Infrastructure System” Key Special Project;
Grants from Ministry of Science and Technology, National Key Research and Development Program of China, “Research on Pathogen and Preventive Technology Systems” Key Special Project;
Grants from Tongji University Original Basic Research Project
