主持科研项目(课题)及人才计划项目情况:
1.国家重点研发计划2024年重点专项课题五,“干细胞衍生物规模化制备关键技术及评价研究”,2024/12-2027/11,940万元,在研,骨干(本人承担60万元课题任务)
2.国家自然科学基金青年项目,“基于患者C9ORF72-ALS-iPS细胞模型研究PTEN-knockdown的神经保护作用的机制”,2015/01-2017/12,23万元,结题,主持。
3.上海思德克索生物科技有限公司,校企合作,横向项目-技术开发,“一种新型外泌体凝胶制剂治疗烧创伤的临床前研究”,2023/10-2025/10,105万元,在研,主持。
4.上海市卫生健康委员会科研项目,面上项目,“基于偶氮萘苯骨架的变形分子对Tau蛋白聚集的抑制及解聚作用研究”,2023/01-2025/12,10万元,在研,主持。
5.上海市卫生和计划生育委员会科研课题,青年项目,“基于荧光传感技术对脊肌萎缩症的基因诊断研究”,2017/01-2019/12,2万元,结题,主持。
6.上海市博士后基金,“利用病人特异的iPSCs脊肌萎缩症疾病模型与致病机制的研究”,2012/03-2013/06,结题,主持。
7.同济大学中央高校基本科研业务费专项资金-学科交叉类,“DNA生物传感器的构建及若干疾病的分子诊断研究”,2017/09-2019/08,20万,结题,主持。
已发表第一作者或通讯作者署名SCI论文:
(1)Tu Ying; Chai Keke; Wu Junjie; Hu Yuan; Shi Shuo; Yang Danjing; Yao Tianming ; A rational design to improve selective imaging of tau aggregates by constructing side substitution on N,N-dimethylaniline/quinoxaline D-π-A fluorescent probe, Sensors and Actuators B: Chemical, 2023, 380(0): p133406.
(2)Jiang, Tianfang; Xu, Chuanying; Gao, Shane; Zhang, Jia; Wu, Xiaolin; Lu, Qiuyun; Gao, Limei; Yang, Danjing; Xu, Jun; Chen, Xu; Cathepsin L-containing exosomes from alpha-synuclein-activated microglia induce neurotoxicity through the P2X7 receptor. NPJ Parkinsons Dis, 2022, 8(1): p. 127.
(3)Yang, Danjing; Wang, XianLi; Ismail, A; Ashman, C J; Valori, C F; Wang, G; Gao, S; Higginbottom, A; Ince, P G; Azzouz, M; Xu, J; Shaw, P J; Ning, K; PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons., Cell Death & Disease, 2014, 5(2): e1096-e1108.
(4)Yang, Danjing; Zhu, Liang; Lin, Xiangyu; Zhu, Jiaming; Qian Yusheng; Liu Wenhui; Chen Jianjun; Zhou Chuncai*; He Jing*; Therapeutic Effects of Synthetic Triblock Amphiphilic Short Antimicrobial Peptides on Human Lung Adenocarcinoma, Pharmaceutics, 2022, 14(5):929.
(5)Hu, Yuan; Yang, Danjing*; Tu, Ying; Chai, Keke; Chu, Lei; Shi, Shuo; Yao, Tianming*; DynamicInspired Perspective on the Molecular Inhibitor of Tau Aggregation by Glucose Gallates Based on Human Neurons, ACS Chem. Neurosci, 2021, 12(21): 4162-4174.
(6)Hu, Yuan; Hu, Xiaochun; Lu, Yonglin; Shi, Shuo; Yang, Danjing*; Yao, Tianming*; New Strategy for Reducing Tau Aggregation Cytologically by A Hairpinlike Molecular Inhibitor, Tannic Acid Encapsulated in Liposome, ACS Chemical Neuroscience, 2020, 11(21): 3623-3634.
(7)Yang, Danjing; Zhu, Liang; Ren, Jie; Ma, Rong Jie; Zhu, Hongwen; Xu, Jun; Dysfunction of autophagy as the pathological mechanism of motor neuron disease based on a patient-specific disease, Neuroscience Bulletin, 2015, 31(4): 445-451.
(8)Yang DanJing; Yao TianMing*; Shi Shuo; Ji LiangNian; The impacts of Hg(II) tightly binding on the Alzheimer’s tau construct R3: misfolding and aggregation, Bull Chem Soc JPN, 2011, 84: 1362-1369.
(9)Yang DanJing; Shi Shuo; Yao TianMing*; Ji LiangNian; Cooperative folding of tau peptide by coordination of group IIB metal cations during heparin-induced aggregation, Biometals, 2012, 25(2): 361-372.
(10)Yang DanJing; Shi Shuo; Zheng LengFeng; Yao TianMing*; Ji LiangNian; Mercury(II) promotes the in vitro aggregation of tau fragment corresponding to the second repeat of microtubule-binding domain: coordination and conformational transition, Biopolymers, 2010, 93 (12): 1100-1107.
发明专利2项,均已授权
(1)石硕; 杨丹静; 朱艳艳; 一种脊肌萎缩症致病基因检测试剂盒及其应用, 中国, 201910490837.1。
(2)杨丹静;柴可可,涂英;姚天明;喹喔啉类荧光探针、方法及应用,中国,202211045629.9。
参编教材及著作
(1)《生命科学综合实验》,同济大学出版社,2018。
(2)《干细胞基础与再生修复技术》,上海交通大学出版社有限公司,2024,ISBN号:978-7-313-30550-3。