2014年获得英国曼彻斯特大学微生物学博士。研究主要开展新型抗菌药物与特异性抗菌药物的筛选和靶点确证工作，尤其是靶向幽门螺杆菌、金黄色葡萄球菌等病原菌的抗菌药物的筛选和靶点确证，发现并揭示了金黄霉素A、唑氟达星、ARM1和DM94等多种新型抗菌（抗多耐药）先导物和抗菌机制。主持国家重点研发计划课题子课题、国家自然科学基金青年项目、面上项目等。近五年来以第一作者或通讯作者在《Science advances》、《Helicobacter》、《Microbial Biotechnology》等相关领域高质量国际期刊发表SCI论文多篇。2016年入选江苏省高层次创新创业人才引进“双创博士”计划。
Dr. Jia received her Ph.D. in Microbiology from the University of Manchester, UK. Her research focuses on the discovery and target validation of novel and pathogen-specific antimicrobial agents, with particular emphasis on Helicobacter pylori (Hp) and Staphylococcus aureus. She has identified and elucidated the antibacterial mechanisms of several promising lead compounds, including ChryA, Zoliflodacin, ARM1, and DM94, with potential activity against multidrug-resistant pathogens. She has led sub-projects under the National Key R&D Program of China and has been awarded both Young Investigator and General Program grants from the National Natural Science Foundation of China. Over the past five years, she has published multiple first- or corresponding-author papers in leading journals such as Science Advances, Helicobacter, and Microbial Biotechnology.
主持科研项目：
1.国家自然科学基金面上项目，天然产物Armeniaspirol A抗幽门螺杆菌的作用靶点及分子机制研究，32470188，50万元，2025.01-2028.12，在研，主持
2.国家重点研发计划子课题，海洋微生物候选药物的成药性评价—抗细菌耐药先导物的药效评价及药动学研究，2018YFC0311005，156.89万元，2019.01-2021.12，结题，主持
3.国家自然科学基金青年项目，青枯菌生物素合成途径中一种新型甲酯二酸单酰ACP酯酶的鉴定及其生物学功能研究，31600039，20万元，2017.01-2019.12，结题，主持
4.国家自然科学基金面上项目，基于细菌不饱和脂肪酸合成新机制的抗幽门螺杆菌药物靶点确证及先导化合物发现研究，82073899，55万元，2020.01-2024.12，在研，第一参与人
5.广东省自然科学基金面上项目，OSMAC策略结合质谱分子网络对新型含氮Citrinin衍生物的定向分离及抗耐药幽门螺杆菌活性评价，2023A1515010432，10万元，2023.01-2025.12，在研，第一参与人
6.江苏省“双创博士”人才计划项目，世界名校（创新）类，2017.01－2018.12，15万元，已结题，主持
代表性论文：
1.Liu, J.*, Jia, J.*, Shi,T., Bai, Y., Huang,Y., Zeng, L., Bi,H. (2024) Evaluating the potency of zoliflodacin against Helicobacter pylori: In vitro activity and conserved GyrB target. Helicobacter 29(2):e13075.
2.Jia, J.*, Zheng, M.*, Zhang, C.*, Li, B., Lu, C., Bai, Y., Tong, Q., Hang, X., Ge, Y., Zeng, L., Zhao, M., Song, F., Zhang, H., Zhang, L., Hong, K., and Bi, H. (2023) Killing of Staphylococcus aureus persisters by a multitarget natural product chrysomycin A. Sci Adv 9, eadg5995
3.Jia, J., Zhang, C., Liu, Y., Huang, Y., Bai, Y., Hang, X., Zeng, L., Zhu, D., and Bi, H. (2022) Armeniaspirol A: a novel anti-Helicobacter pylori agent. Microb Biotechnol 15, 442-454
4.Chen, S. Q.*, Jia, J.*, Hu, J. Y., Wu, J., Sun, W. T., Zheng, M., Wang, X., Zhu, K. K., Jiang, C. S., Yang, S. P., Zhang, J., Wang, S. B., and Cai, Y. S. (2022) Iboga-type alkaloids with Indolizidino[8,7-b]Indole scaffold and bisindole alkaloids from Tabernaemontana bufalina Lour. Phytochemistry 196, 113089
5.Gou, X.*, Jia, J.*, Xue, Y.*, Ding, W., Dong, Z., Tian, D., Chen, M., Bi, H., Hong, K., and Tang, J. (2020) New pyrones and their analogs from the marine mangrove-derived Aspergillus sp. DM94 with antibacterial activity against Helicobacter pylori. Appl Microbiol Biotechnol 104, 7971-7978
6.Zeng, Q., Yang, Q., Jia, J.#, and Bi, H#. (2020) A Moraxella Virulence Factor Catalyzes an Essential Esterase Reaction of Biotin Biosynthesis. Front Microbiol 11, 148
7.Cen, S.*, Jia, J.*, Ge, Y., Ma, Y., Li, X., Wei, J., Bai, Y., Wu, X., Song, J., Bi, H., and Wu, B. (2021) A new antibacterial 3,5-dimethylorsellinic acid-based meroterpene from the marine fungus Aspergillus sp. CSYZ-1. Fitoterapia 152, 104908
8.Hang, X., Zeng, Q., Zeng, L., Jia, J.#, and Bi, H.# (2019) Functional Replacement of the BioC and BioH Proteins of Escherichia coli Biotin Precursor Biosynthesis by Ehrlichia chaffeensis Novel Proteins. Curr Microbiol 76, 626-636
9.Jia, J., King, J. E., Goldrick, M. C., Aldawood, E., and Roberts, I. S. (2017) Three tandem promoters, together with IHF, regulate growth phase dependent expression of the Escherichia coli kps capsule gene cluster. Sci Rep 7, 17924
10.Li, J., Wang, Y., Hao, X., Li, S., Jia, J., Guan, Y., Peng, Z., Bi, H., Xiao, C., Cen, S., and Gan, M. (2019) Broad-Spectrum Antiviral Natural Products from the Marine-Derived Penicillium sp. IMB17-046. Molecules 24
11.Qiao, Y., Yan, J., Jia, J., Xue, J., Qu, X., Hu, Y., Deng, Z., Bi, H., and Zhu, D. (2019) Characterization of the Biosynthetic Gene Cluster for the Antibiotic Armeniaspirols in Streptomyces armeniacus. J Nat Prod 82, 318-323
授权专利：
(1) 毕洪凯; 黄衍强; 杭旭东; 曾利平; 贾佳; 亚麻酸锌的制备及其在制备抗幽门螺杆菌药物中的应用，2019-04-05, 中国, ZL 2018 1 0462768.9 （专利）
(2) 刘玲; 郭良栋; 郭龙芳; 贾佳; 抗幽门螺旋杆菌活性的蒽醌类化合物及其应用, 2021-10-01，中国，ZL 2019 1 1038374.1 （专利）
(3) Hongkai Bi; Yanqiang Huang; Xudong Hang; Liping Zeng; Jia Jia; PREPARATION OF ZINC LINOLENATE, AND APPLICATION OF ZINC LINOLENATE IN PREPARING ANTI-HELICOBAC-TER PYLORI DRUG，2021，US，11,203,563 B2 （专利）
