【科研方向】
长期聚焦胃肠道肿瘤信号转导机制，围绕 Hippo 信号通路调控胃肠肿瘤的病理功能与分子机制，取得一系列原创科学发现并研发了双环螺旋肽、多肽胶水等前体药物。迄今共发表研究论文 18 篇，其中 10 篇以（共同）第一或通讯作者身份在 Cancer Cell (2020)、EMBO J (2020，2024), J Biol Chem(2024)等期刊上发表。研究成果被 Cancer Cell 及 Sci Transl Med 等期刊点评推荐；并获批发明专利 4 项。申请人受邀参与编写《高通量筛选实验技术手册》一书，主持包括基金委青年基金及面上项目、上海市科委自然科学面上项目、同济大学基础创新项目等各类科研项目共计10 项，并入选上海市青年科技启明星（A类）。
【项目情况】
1．国家自然科学基金面上项目，49万 (2026-2029)
2．国家自然科学基金面上项目，54万 (2023-2026)
3．国家自然科学基金青年基金，24万 (2021-2023)
4. 上海市“科技创新行动计划”自然科学基金面上项目，20万（2022-2025）
5. 上海市青年科技启明星计划，40万 (2022-2025)
6. 遗传国家重点实验室开放课题，30万 (2025-2027)
7. 同济大学自主原创探索项目，12万 (2024-2026)
8. 上海市第十人民医院培育项目，10万 (2024-2026)
【主要论文】
1) Tang Y*, Chen M*, Zhou L*, Ma J*, Li Y, Zhang H, Shi Z, Xu Q, Zhang X, Gao Z, Zhao Y, Cheng Y, Jiao S#, Zhou Z#, Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discov, 2019, 8;5:3.
2）Tang Y*, Fang G*, Guo F*, Zhang H*, Chen X, An L, Chen M, Zhou L, Wang W, Ye T, Zhou L, Nie P, Yu H, Lin M, Zhao Y, Lin X, Yuan Z, Jiao S#, Zhou Z#. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell. 2020 Jul 13;38(1):115-128.e9.
3) Xu J*, Tang Y*, Sheng X, Tian Y, Deng M, Du S, Lv C, Li G, Pan Y, Song Y, Lou P, Luo Y, Li Y, Zhang B, Chen Y, Liu Z, Cong Y, Maksim V Plikus, Meng Q, Zhou Z#, Yu Z#, Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling. EMBO J, 2020, 39(7): e103255.
4) Chen X*, Tang Y*, Wu M*, Zhang Y, Chen K, Zhou Z#, Fang G#, Helix-Constrained Peptides Constructed by Head-to-Side Chain Cross-Linking Strategies. Org Lett, 2021, 23(20):7792-7796.
5) Tang Y, Jiao S, Zhou Z, Screening of Negative Regulators of Hippo Pathway in Gastric Cancer Cells with Nuclear Translocation of YAP as Readout. Bio-Protocol, 2021, e1010822.
6) Tang Y, Jiao S, Zhou Z, Screening of Ferroptosis Regulators in Gastric Cancer Cell-PI/Hoechst Staining. Bio-Protocol, 2021, e1010823.
7) Chen K*, Tang Y*, Wu M*, Wan X, Zhang Y, Chen X, Yu F, Cui Z, Ma J, Zhou Z#, Fang G#, Head-to-Tail Cross-Linking to Generate Bicyclic Helical Peptides with Enhanced Helicity and Proteolytic Stability. Org Lett, 2022, 24(1):53-57.
8) Tang Y*, Chen F*, Fang G*, Zhang H, Zhang Y, Zhu H, Zhang X, Han Y, Cao Z, Guo F, Wang W, Ye D, Ju J, Tan L, Li C, Zhao Y, Zhou Z#, An L#, Jiao S#. A cofactor-induced repressive type of transcription factor condensation can be induced by synthetic peptides to suppress tumorigenesis. EMBO J. 2024 Nov;43(22):5586-5612.
9) Cao Z, Hou Y, Zhao Z, Zhang H, Tian L, Zhang Y, Dong C, Guo F, Tan L, Han Y, Wang W, Jiao S, Tang Y#, An L#, Zhou Z#. Reactivating Hippo by drug compounds to suppress gastric cancer and enhance chemotherapy sensitivity. J Biol Chem. 2024 Jun;300(6):107311.
10) Zhang Y*, Wan X*, Tang Y*, Chen Y, Zhang H, Cui Z, Zheng F, Zhou Z, Fang G. Employing unnatural promiscuity of sortase to construct peptide macrocycle libraries for ligand discovery. Chem Sci. 2024 22;15(25):9649-9656.
Long focused on the signal transduction mechanisms of gastrointestinal tumors, centered on the pathological functions and molecular mechanisms of the Hippo signaling pathway in regulating gastrointestinal tumors. They have made a series of original scientific discoveries and developed precursor drugs such as bicyclic helical peptides and peptide glues.
So far, a total of 18 research papers have been published, among which 10 were published as (co-)first author or corresponding author in journals including Cancer Cell (2020), EMBO Journal (2020, 2024), and Journal of Biological Chemistry (2024). Their research achievements have been commented on and recommended by journals such as Cancer Cell and Science Translational Medicine, and they have obtained 4 authorized invention patents.
Invited to participate in compiling the book Handbook of High-Throughput Screening Experimental Techniques. They have presided over a total of 10 scientific research projects, including the Youth Fund and General Program of the National Natural Science Foundation of China, the General Program of Natural Science of the Shanghai Science and Technology Commission, and the Basic Innovation Project of Tongji University. Additionally, the applicant was selected into the Shanghai Youth Science and Technology Star Program (Category A).
