蒋晓燕，女，汉族，博士。同济大学医学院教授，博士生导师，心脏病全国重点实验室与东方医院科创中心特聘研究员。为如皋衰老纵向队列Co-PI（Rugao Longevity and Ageing Study, RuLAS），RuLAS队列已进行6次重测随访（2014年wave1, 2016年wave2, 2017年wave3, 2019年wave4, 2021年wave5, 2023年wave6），已建成具有一定国际知名度的多维度深度纵向表型（心眼肾代谢等器官系统、躯体社会心理等功能、组学标志物）及重大慢病发病死因随访的前瞻性队列。建立队列数据库，建立多学科多维度深度纵向表型、基因组、代谢组、宏基因组、甲基化等多组学数据库。研究方向：心血管与代谢性疾病分子和遗传流行病学。长期从事心血管代谢性疾病及衰弱的分子和遗传流行病学研究，并有多年的多基因病与药物遗传学咨询、心血管药理学及病理生理学研究教学经历。主持国家自然科学基金面上项目、国家自然科学基金青年基金、国家教育部博士点新教师基金、上海市自然科学基金、中央高校基本科研业务费专项基金等项目。为国家重点研发计划“主动健康和老龄化科技应对”专项“老年衰弱快速筛查评估量表的研发与建立”任务责任人。发表SCI论文近70篇，其中以通讯或第一作者（含并列）名义发表SCI论文30篇。获济南市科技进步二等奖（2015，排名第二）。是国家自然科学基金及教育部博士学位论文评审专家以及J Nutr Health Aging、Frontiers in Public Health、Molecular Biology Reports、Psychiatry Research等国际SCI期刊的审稿人。

特别欢迎有生物信息背景的学生报考。

Xiao-Yan Jiang, Ph.D., Professor (Ph.D.Supervisor) of the key laboratory of arrhythmias of ministry of Education of China and the assistant director of the department of pathology and pathophysiology. Research field: molecular epidemiology in cardiology and metabolic disease. Reviewer of the National Natural Science Foundation, the Doctoral Dissertation of the Ministry of Education, and the SCI journals (J Nutr Health Aging, Frontiers in Public Health, Molecular Biology Reports, Psychiatry Research). Grants: the National Key R&D Program of China；the National Natural Science Foundation; the Research Fund for the Doctoral Program of Higher Education of China; the Shanghai Municipal Natural Science Foundation; the Fundamental Research Funds for the Central Universities. Awards: the Second Prize of Jinan Science and Technology Progress Award (2015, rank second).

为如皋衰老纵向队列Co-PI（Rugao Longevity and Ageing Study, RuLAS）。

近5年发表文章(Publication)：*通讯作者(corresponding author)，#并列第一(co-first author)

1.Na Zhang#, Jianghong Guo#, Mengya Zhang, Yingmei Yu, MeiGuo, HaoXu, ZhendongWang, LinliangWu, XiaofengWang, Xiaoyan Jiang*. Sleep disturbances and intrinsic capacity trajectories among Chinese older adults: The Rugao Longevity and Ageing Study. Geriatric Nursing.2024,60;150-155. (corresponding author)

2.Dai Q#, Ma Y#, Liu C, Zhao R, Chen Q, Chen W, Wang X, Jiang X*, Li S*. Association of 8-hydroxy-2’-deoxyguanosine with motoric cognitive risk in elderly Chinese people: RUGAO longevity and aging cross-sectional study. BMC Geriatr. 2024 Apr 11;24(1):331. doi: 10.1186/s12877-024-04943-0. （co-corresponding author)

3.Liu He#, Zhoutao Zheng#, Xueqin Li, Xingqi Cao, Jingyun Zhang, Chen Chen, Yuebin Lv, Chenkai Wu, Lisa C. Barry, Zhimin Ying*, Xiaoyan Jiang*, Xiaoming Shi, Zuyun Liu*. Association of spouse’s health status with the onset of depressive symptoms in partner evidence from the China Health and Retirement Longitudinal Study. J Affect Disord. 2023 Mar 15;325:177-184. doi: 10.1016/j.jad.2022.12.118.（co-corresponding author)

4.H Zhang#, M Sun#, Z Hu, Y Cao, M Hao, Y Li, L Jin, X Sun, X Wang, X Jiang*. Association of Arterial Stiffness with Functional Disability and Mobility Limitation: The Rugao Longitudinal Ageing Study. J Nutr Health Aging. 2022; 26(6):598-605. doi: 10.1007/s12603-022-1802-z. (corresponding author)

5.JY Zhang#, SH Yu#, G Zhao, X Jiang*,Y Zhu*，Z Liu*. Associations of chronic diarrheal symptoms and inflammatory bowel disease with sleep quality. Front Neurol. 2022 Aug 24;13:858439. （co-corresponding author)

6.Yuan JL#, Zhao RX#, Ma YJ, Li XD, Zhou XM, Wang XF, Jiang XY*, Li SJ*. Prevalence/potential risk factors for motoric cognitive risk and its relationship to falls in Chinese elderly people: A cross-sectional study. Eur J Neurol. 2021; 28(8):2680-2687. doi: 10.1111/ene.14884. （co-corresponding author)

7.Ma Y#, Li X#, Pan Y, Zhao R, Wang X, Jiang X*, Li S*.Cognitive frailty and falls in Chinese older people：a population-based longitudinal study. Eur J Neurol. 2021; 28(2):381-388. doi: 10.1111/ene.14572.（co-corresponding author)

8.Ma Y#, Li X#, Pan Y, Zhao R, Wang X, Jiang X*, Li S*. Cognitive frailty predicting death and disability in Chinese elderly. Neurol Res. 2021; 43(10):815-822. doi: 10.1080/01616412.2021.1939235. （co-corresponding author)

9.Guo JH#, Shi JM#, Shi GP, Wang Y, Chu XF, Wang ZD, Yao S, Sun XH, Wang XF, Zhu YS*, Jiang XY*. Association Study of Mitochondrial DNA Haplogroup D and C5178A Polymorphisms with Chronic Kidney Disease. Genet Test Mol Biomarkers. 2021; 25(8):546-550. doi: 10.1089/gtmb.2020.0306. （co-corresponding author）

10.Chen Z#, Jiang X#, Shi G, Wang Y, Chu X, Wang Z, Guo J, Zhu Y, Chen J, Wang X, Bao Z*. Social frailty and longitudinal risk of depressive symptoms in a Chinese population: the Rugao Longevity and Aging Study. Psychogeriatrics. 2021; 21(4):483-490. doi: 10.1111/psyg.12696. （co-first author）

11.Sun XH#, Ma T#, Yao S, Chen ZK, Xu WD, Jiang XY*, Wang XF*. Associations of sleep quality and sleep duration with frailty and pre-frailty in an elderly population Rugao longevity and ageing study. BMC Geriatr. 2020; 20(1):9. doi: 10.1186/s12877-019-1407-5. （co-corresponding author)

12.Ma T#, Sun XH#, Yao S, Chen ZK, Zhang JF, Xu WD, Jiang XY*, Wang XF*. Genetic Variants of Homocysteine Metabolism, Homocysteine, and Frailty - Rugao Longevity and Ageing Study.J Nutr Health Aging. 2020;24(2):198-204. doi: 10.1007/s12603-019-1304-9. （co-corresponding author)

13.Li YX#, Jiang XY#, Stone C, Ma YJ, Liu Q, Hu ZH, Li XD, Wang XF, Li SJ. A new physical-cognitive scale for assessment of frailty in Chinese Han elderly. Neurol Res. 2019; 41(8):728-733. doi: 10.1080/01616412.2019.1609164.（co-first author）

14.Shi GP#, Ma T#, Zhu YS, Wang ZD, Chu XF, Wang Y, Chen ZK, Xu WD, Wang XF, Guo JH, Jiang XY*. Frailty phenotype, frailty index and risk of mortality in Chinese elderly population- Rugao longevity and ageing study. Arch Gerontol Geriatr. 2019; 80:115-119.（co-corresponding author）

15.Zhang H, Hu Z, Jiang S, Hao M, Li Y, Liu Y, Jiang XY, Jin L, Wang X. Social frailty and the incidence of motoric cognitive risk syndrome in older adults. Alzheimers Dement. 2024 Apr;20(4):2329-2339.

16.Hao M#, Zhang H# Li Y#, Hu X, Hu Z, Jiang X, Wang J, Sun X, Liu Z, Davis D, Jin L*, Wang X*. Using physiological system networks to elaborate resilience across frailty states. J Gerontol A Biol Sci Med Sci. 2023 Oct 12:glad243. doi: 10.1093/gerona/glad243.

17.Hao M#, Zhang H#, Hu Z, Jiang X, Song Q, Wang X, Wang J, Liu Z*, Wang X*, Li Y*, Jin L*. Phenotype correlations reveal the relationships of physiological systems underlying human ageing. Aging Cell. 2021; 20(12):e13519.

18.Zhang H#, Hao M#, Hu Z#, Li Y, Jiang X, Wang J, Jin L, Liu Z, Wang X*, Sun X*. Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study. Immun Ageing. 2022 Jan 3;19(1):1

19.Zhang H, Hao M, Li Y, Jiang X, Wang M, Chen J, Wang X*, Sun X*.Glomerular filtration rate by different measures and albuminuria are associated with risk of frailty: the Rugao Longitudinal Ageing Study. Aging Clin Exp Res. 2022 Nov;34(11):2703-2711.

20.Zhang H#, Shen H#, Gong W, Sun X, Jiang X, Wang J, Jin L, Xu X, Luo D*, Wang X*. Plasma Homocysteine and Macular Thickness in Older Adults-the Rugao Longevity and Aging Study. Eye (Lond). 2022;36(5):1050-1060.

21.Zhang H#, Li Y#, Hao M, Jiang X, Wang J, Jin L, Bao Z*, Wang X*. Kidney function decline is associated with an accelerated increase in plasma homocysteine in older adults: a longitudinal study. Br J Nutr. 2022;127(7):993-999.

22.H Zhang#, M Hao#, Z Hu, Y Li, X Hu, X Jiang, Z Liu, X Sun*, X Wang*. Causal Association of Cardiac Function by Magnetic Resonance Imaging with Frailty Index: A Mendelian Randomization Study. Phenomics, 2022, https://doi.org/10.1007/s43657-022-00072-z

23.Zhang H#, Zhu Y#, Hao M, Wang J, Wang Z, Chu X, Bao Z, Jiang X, Shi G*, Wang X*. The modified Healthy Aging Index is Associated with Mortality and Disability: The Rugao Longevity and Ageing Study. Gerontology. 2021;67(5):572-580.

24.Zhang H#, Zhu Y#, Gong W, Sun X, Jiang X, Wang J, Jin L, Xu X, Luo D*, Wang X*. Plasma Homocysteine and Macular Thickness in Older Adults-the Rugao Longevity and Aging Study. Eye (Lond). 2022; 36(5):1050-1060. doi: 10.1038/s41433-021-01549-3.

25.Zhang H#, Li Y#, Hao M, Jiang X, Wang J, Jin L, Bao Z*, Wang X*. Kidney function decline is associated with an accelerated increase in plasma homocysteine in older adults: a longitudinal study. Br J Nutr. 2022;127(7):993-999.

26.Chu X#, Zhang N#, Shi G, Wang Y, Wang Z, Guo J, Jiang X, Jin L, Wang X*, Zhu Y*. Frailty and Incident Depressive Symptoms in a Chinese Sample: The Rugao Longevity and Ageing Study. Psychogeriatrics. 2020;20(5):691-698.

27.Wang Z#, Yao S#, Shi G, Wang Y, Shi J, Guo J, Zhu Y, Jiang X, Chu X*, Wang X*.Frailty index is associated with increased risk of elevated BNP in an elderly population: the Rugao Longevity and Ageing Study. Aging Clin Exp Res. 2020;32(2):305-311.

28.Yao S, Zhu Y , Shi G, Guo J, Wang Z, Chu X, Jiang X, Jin L*, Wang X*. Associations of TNF-α -308 G>A and TNF-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study. J Nutr Health Aging. 2020;24(3):358-363.

29.Zhang N#, Shi GP#, Wang Y, Chu XF, Wang ZD, Shi JM, Guo JH, Wang YC, Yao S, Jiang XY, Zhu YS*, Wang XF*. Depressive symptoms are associated with incident frailty in a Chinese population- the Rugao Longevity and Ageing Study. Aging Clin Exp Res. 2020;32(11):2297-2302.

30.Yao S#, Guo J#, Shi G, Zhu Y, Wang Y, Chu X, Jiang X, Jin L, Wang Z*, Wang X*. Association Of BNP with frailty in elderly population: Rugao Longevity and Ageing Study. J Nutr Health Aging. 2019;23(1):73-78.