2001年获全国高中生物学竞赛（重庆赛区）一等奖，2006年于四川大学生命科学学院/吴玉章学院获生物技术学士学位，2011年于清华大学生命科学学院获生物学博士学位。先后在美国加州大学圣迭戈分校（UCSD）诺贝尔生理与医学奖得主实验室，以及新加坡科技局（A*STAR）基因组研究院从事博士后研究。2015年入职同济大学担任教授/博士生导师（PI)。
课题团队深入开展基于成体干细胞的肺、肾等重要脏器的再生修复、功能增强与青春恢复研究。主导完成世界上首个肺干细胞移植再生肺脏临床研究。论文成果发表在Nature、Science Translational Medicine、Nature Communications、Science Advances、Cell Reports Med、eLife、EMBO Mol Med、AJRCCM等顶级期刊上, 单篇通讯论文被引超2000次。领导开发了全球首创肺干细胞1类新药REGEND001和肾干细胞新药REGEND003，获3项国家药监局临床批件及1项美国FDA孤儿药认证，并主导完成多个II期临床试验。研究成果先后入选“中国医药生物技术年度十大进展”和欧洲呼吸学会(ERS)发布的全球年度三大重要进展，并登上《科学》期刊官网首页。2025年成果获批海南博鳌首批干细胞治疗技术应用，累计成功实现数百例患者的器官再生修复治疗。开发的全自动干细胞培养装备获山东省科技进步一等奖。
左为教授先后入选国家青年特聘专家、国家教育部青年长江学者、国自然优秀青年基金、浙江省千人计划专家、江苏省双创专家、江西省双千计划专家等人才计划。多次获国家重点研发计划、国家新药创制中心揭榜挂帅等重大项目资助。曾被国家刊物官方评选为“中国年度十大创新先锋”，被誉为中国的“再生天才（Regeneration Genius）”。先后获“中国科学家创业先锋”，“中国生命科学新力量十大年度人物”等荣誉称号。
Publications 代表性论著 （# corresponding author, 通讯作者）
1. Zou T*, Zhang S*, Liu M*, Chen Q, Wang S, Niu L, Chen YG#, Zhang T#, Zuo W#. Control of airway basal stem cell-mediated lung repair by TGF-β signaling. Science Advances. 2026 Jan 9;12(2). IF=12.5
2. Nie H*, Liang C*, He Y*, Wang S*, Zhang X, Duan J, Huang J, Yu C, Wang Y, Zhao Z, Zuo W#, Zhang T#. Implant Renal Injury-Responsive Cells to Supplement Erythropoietin and Protect Kidney Injury. MedComm. 2025 Oct 30;6(11):e70438. doi: 10.1002/mco2.70438. IF=10.7
3. Zhao Y*, Zhou Y*, Zhang W*, Liu M, Duan J, Zhang X, Ma Q, Wang Y, Zhang Y, Guo Z#, Zhang T#, Zuo W#. Cloned airway basal progenitor cells to repair fibrotic lung through re-epithelialization. Nature Communications. 2025 Feb 3;16(1):1303. IF=15.7
4.Yan J*, Zhang W*, Feng Y*, Liu X*, Niu L, Guo Y, Zhou L, Shi M, Di C, Zhang Q, Wang X, Zhou J, Dai R, Ni L, Bao Z, Yan T, Hu Y, Wang P, Zhang T, Zhou M#, Zuo W#, Qu J#. Autologous transplantation of P63+ lung progenitor cells in patients with bronchiectasis: A randomized, single-blind, controlled trial. Cell Reports Med. 2024 Nov 19;5(11):101819. IF=11.7
5. Wang Y*, Meng Z*, Liu M*, Zhou Y*, Chen D*, Zhao Y, Zhang T, Zhong N#, Dai X#, Li S#, Zuo W#. Autologous transplantation of P63+ lung progenitor cells for chronic obstructive pulmonary disease therapy. Science Transl Med. 2024 Feb 14;16(734):eadi3360. IF=17.1 (Science官网首页)
6. Hong X*, Nie H*, Deng J, Liang S, Chen L, Li J, Gong S, Wang G, Zuo W#, Hou F#, Zhang F#. WT1+ glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury. Theranostics. 2023 Feb 21;13(4):1311-1324. IF=12.4
7. Liang C*, Zhao Z*, Liu S, Zhang T, Zuo W#. Single-cell transcriptome profiling of the vaginal epithelium reveals the heterogeneity of suprabasal cells. Precis Clin Med. 2023 Mar 20;6(1):pbad006.
8. Nie H*, Zhao Z*, Zhou D, Li D, Wang Y, Ma Y, Liu X, Zuo W#. Activated SOX9+ renal epithelial cells promote kidney repair through secreting factors. Cell Prolif. 2023 Apr;56(4):e13394. IF=8.755
9. Zhao Z, Wang Y, Wu Y, Li D, Zhang T, Ma Y, Teng X, Zuo W# (2021). Single-cell analysis defines the lineage plasticity of stem cells in cervix epithelium. Cell Regeneration. Nov 1;10(1):36.
10. Wang X, Zhao Y, Li D, Feng Y, Xie Y, Zhou Y, Zhou M, Wang Y#, Qu J#, Zuo W# (2021). Intrapulmonary distal airway stem cell transplantation repairs lung injury in chronic obstructive pulmonary disease. Cell Prolif. e13046. IF=8.76
11. Wang Y, Zhao Y, Zhao Z, Li D, Nie H, Sun Y, Feng X, Zhang T, Ma Y, Nie J, Cai G#, Chen X#, Zuo W# (2021). Single-cell RNA-Seq analysis identified kidney progenitor cells from human urine. Protein Cell. 12(4):305-312. IF=15.33
12. Zhao Y, Zhao Z, Wang Y, Zhou Y, Ma Y, Zuo W# (2020). Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2. Am J Respir Crit Care Med. 202(5):756-759. IF= 30.53
13. Zhou Y, Shi Y, Yang L, Sun Y, Han Y, Zhao Z, Wang Y, Liu Y, Ma Y, Zhang T, Ren T, Dale T, Forsyth N, Jin F, Qu J#, Zuo W#, Xu J# (2019). Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection. EMBO Molecular Medicine. e10233. IF=14.26
14. Ma Q, Ma Y, Dai X, Ren T, Fu Y, Liu W, Han Y, Wu Y, Cheng Y, Zhang T, Zuo W# (2018). Regeneration of functional alveoli by adult human SOX9airway basal cell transplantation. Protein Cell. 9(3):267-282.（Cover story）IF=15.33
15. Zhang T, Li S, Zuo W# (2015). Landscape of protein domain interactome. Protein & Cell. 6(8), 610-614. IF=15.33
16. Zuo W, Zhang T, Wu DZ, Guan SP, Liew AA, Lim T, Yamamoto Y, Wang X, Lim SJ, Vincent M, Lessard M, Crum CP, Xian W, McKeon F. (2015). p63+/Krt5+ distal airway stem cells are essential for lung regeneration. Nature. 517,616-620. (“F1000”recommended; Highlighted and commented by Nature, Nature Biotechnology, Transplantation, European Journal of Respiratory etc. ) IF=69.5
17. Zuo W, Huang F, Chiang J, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen YL, Deng HT, Feng XH, Luo SW, Gao CJ, Chen YG. (2013). c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of TGF-β type II receptor. Mol Cell 49 (3), 499-510 (“F1000”recommended ) IF=19.33
18. Zuo W, Chen YG (2009). Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity. Mol Biol Cell 20(3), 1020-1029.
