主要从事DNA损伤修复、蛋白质翻译后修饰与肿瘤发生发展的相关研究，研究成果以通讯或者第一作者在Science Advances（2023，2019），Nucleic Acids Res，Theranostics，Oncogene，Cell Death and Disease等杂志上发表多篇原创性论文，作为项目负责人承担科研项目9项，包括国家自然科学基金、上海市科委项目等，并获得上海市“科技创新行动计划”启明星计划。
代表性研究论文如下：
1. Tang Ming#*, Chen Guofang#, Tu Bo#, Hu Zhiyi, Huang Yujia, DuFort C. Christopher, Wan Xiaoping, Mao Zhiyong, Liu Yongzhong*, Zhu Wei-Guo*, Lu Wen*. SMYD2 inhibition mediated hypomethylation of Ku70 contributes to impaired non-homologous end joining repair and anti-tumor immunity, Science Advances, 2023, 9(24): eade6624. (第一作者兼共同通讯)
2. Tang Ming#, Li Zhiming#, Zhang Chaohua, Lu Xiaopeng, Tu Bo, Cao Ziyang, Li Yinglu, Chen Yongcan, Jiang Lu, Wang Hui, Wang Lina, Wang Jiadong, Liu Baohua, Xu Xingzhi, Wang Haiying, Zhu Wei-Guo*, SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair, Science Advances, 2019, 5(3): eaav1118. (第一作者)
3. Tang Ming#, Lu Xiaopeng#, Zhang Chaohua, Du Changzheng, Cao Linlin, Hou Tianyun, Li Zhiming, Tu Bo, Cao Ziyang, Li Yinglu, Chen Yongcan, Jiang Lu, Wang Hui, Wang Lina, Liu Baohua, Xu Xingzhi, Luo Jianyuan, Wang Jiadong, Gu Jin, Wang Haiying*, Zhu Wei-Guo*, Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer, Theranostics, 2017, 7(5):1346-1359. (第一作者)
4. Tang Ming#, Shasha Yin#, Hongliang Zeng#, Ao Huang#, Yujia Huang, Zhiyi Hu, Ab Rauf Shah, Shuyong Zhang*, Haisen Li*, Guofang Chen*, The P286R mutation of DNA Polymerase ε activates cancer-cell-intrinsic immunity and suppresses endometrial tumorigenesis via the cGAS-STING pathway, Cell Death & Disease, 2024, 15(1):69.（第一作者）
5. Tang Ming#, Tang Huangqi#, Tu Bo, Zhu Wei-Guo*, SIRT7: a sentinel of genome stability, Open Biology, 2021, 11(6):210047. (第一作者)
6. Lu Xiaopeng#, Tang Ming#, Zhu Qian, Yang Qiaoyan, Li Zhiming, Bao Yantao, Liu Ge, Hou Tianyun, Lv Yafei, Zhao Ying, Wang Haiying, Yang Yang, Cheng Zhongyi, Wen He, Liu Baohua, Xu Xingzhi, Gu Luo, Zhu Wei-Guo*, GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival, Nucleic Acids Res, 2019,47(21):10977-10993. (共同第一作者)
7. Ma Aihui#, Tang Ming#, Zhang Li, Wang Boshi, Yang Zhaojuan, Liu Yun, Xu Guiqin, Wu Lin, Jing Tiantian, Xu Xiaoli, Yang Shengli, Liu Yongzhong*, USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis, Oncogene, 2018,38(13):2405-2419. (共同第一作者)
8. Huang Yujia#, Tang Ming#*, Hu Zhiyi#, Cai Bailian, Chen Guofang, Jiang Lijun, Xia Yan, Guan P, Li X, Mao Z, Wan X*, Lu W*. SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair, Oncogenesis, 2024, 13(1):3.（共同第一作者兼共同通讯）
9. Zhai Zichao#, Tang Ming#, Yang Yue, Lu Ming, Zhu Wei-Guo*, Li Tingting*, Identifying Human SIRT1 Substrates by Integrating Heterogeneous Information from Various Sources, Sci Rep, 2017, 7(1):4614. (共同第一作者)
10. Tu Bo#, Bao Yantao#, Tang Ming#, Zhu Qian, Lu Xiaopeng, Wang Hui, Hou Tianyun, Zhao Ying, Zhang Ping*, Zhu Wei-Guo*, TIP60 recruits SUV39H1 to chromatin to maintain heterochromatin genome stability and resist hydrogen peroxide-induced cytotoxicity, Genome Instability & Disease, 2020, 1, 339-355. (共同第一作者)
