主要从事炎症性肠病(IBD)的诊治,主要研究方向为肠道微生态与肠道免疫、IBD多组学分析以及医学人工智能转化应用研究。
【主持科研项目】
国家自然科学基金委员会, 青年科学基金项目, 81700457, IBD患者树突状细胞过表达OX40L致 F.prausnitzii定植失能的机制研究, 2018-01-01 至 2020-12-31, 22万元, 结题, 主持。
山东省科技厅, 省自然面上项目, ZR2022MH098, UC患者肠道厌氧菌共有蛋白PFOR调节IFN-γ的机制研 究, 2023-01 至 2025-12, 10万元, 在研, 主持。
国家自然科学基金委员会,面上项目,82370536,肠外应用普氏粪杆菌保护肠黏膜机制研究,2024-01-01 至 2027-12-31, 48万元, 在研, 主持。
同济大学医学+X交叉研究项目,2025-0553-YB-04,炎症性肠病患者机会性感染AI预警模型的建立和应用,2025-1-1至2027-12-31,20万元,在研,主持
【发明专利】
ZL 2020 1 0157344.9, PFOR蛋白特异性IgA抗体作为溃疡性结肠炎诊断标志物中的应用,发明人:李铭,王楷若
【代表性论著】
2013 Surface maturation scoring for oesophageal squamous intraepithelial neoplasia: a novel diagnostic approach inspired by first endomicroscopic 3dimensional reconstruction. Gut 第一作者
2014 Virtual gastroscopy for the evaluation of stomach malignancy. Endoscopy 第一
2014 Kudo’s pit pattern classification for colorectal neoplasms: A meta analysis. WJG 共一
2015 Endomicroscopy Will Track Injected Mesenchymal Stem Cells in Rat Colitis Models IBD 第一
2016 Visceral hypersensitive rats share common dysbiosis features with irritable bowel syndrome patients. WJG 共一
2016 Human colorectal mucosal microbiota correlates with its host niche physiology revealed by endomicroscopy. Scientific Reports 共一
2020 Fusobacterium nucleatum Causes Microbial Dysbiosis and Exacerbates Visceral Hypersensitivity in a Colonization-Independent Manner. Frontiers in Microbiology 共通 2/2
2021 Sequential laxative-probiotic usage for treatment of irritable bowel syndrome: a novel method inspired by mathematical modelling of the microbiome. Scientific Reports 共一 1/2
2021 Looking into key bacterial proteins involved in gut dysbiosis World journal of methodology 通讯.
2022 Gut Microbiota in Systemic Lupus Erythematosus and Correlation With Diet and Clinical Manifestations. Frontiers in Medicine 通讯
2022 Pyruvate: Ferredoxin oxidoreductase is involved in IgA-related microbiota dysbiosis and intestinal inflammation. Frontiers in Immunology 通讯
2024 Dysbiosis and Staphylococcus species over representation in the exit site skin microbiota of hemodialysis patients carrying tunneled cuffed central venous catheter. Renal Failure通讯