上海市东方医院南院消化科主任
Director, Department of Gastroenterology, Southern Campus of Shanghai East Hospital
上海市中西医结合学会消化专委会主任委员
Director of Digestive Committee of Shanghai Association of Integrated Traditional Chinese and Western medicine
上海市医学会消化分会炎症性肠病学组委员
Member of inflammatory bowel disease group, digestive branch, Shanghai Medical Association
上海市医学会肝病学会肝纤维化学组委员
Member of Liver Fibrosis Group, Society of Hepatology, Shanghai Medical Association
上海市医师协会消化分会委员
Member of the standing committee, Digestive branch of Shanghai Physicians Association
上海市康复医学会第一届消化康复专业委员会
Member of the first Digestive Rehabilitation Committee of Shanghai Society for Rehabilitation Medicine
国家医学考试中心试题开发专家委员会委员
Member of Expert Committee, the National Medical Examination Center
国家医学考试中心试题开发专家委员会消化专业组副组长
Vice-chairman of group of digestive disease, expert committee of National Medical Examination Center
主要研究领域涉及慢性肝病及肝纤维化、炎症性肠病等消化道疾病，在国内较早建立了肥胖、高脂血症性NASH的动物模型，并开展了系列研究。近年来致力于揭示炎症性肠病发病机制和肠-肝对话，解析新的治疗靶点，建立了炎症性肠病的生物样本库，创新性开展人脐带间充质干细胞治疗难治性中重度克罗恩病的临床研究（NCT05262829）。发表SCI论文总影响因子80分以上，主要代表作发表于Lancet子刊Ebiomedicine，荣获2025年由上海市卫健委、上海市科委、上海市经信委、上海市知识产权局及上海市药监局联合举办的“春昇杯”医学创新人才大赛优胜奖，并获中国医学论坛报等主流媒体报道，此外，还获得了上海市浦东新区优秀科技论文三等奖、上海市医学科技奖三等奖和上海市科学技术进步奖三等奖（第五完成人）等，目前主持国家自然科学基金面上项目、浦东新区学科卫健委建设项目及临床研究专项等各级课题多项，同时还作为PI承担炎症性肠病相关新药临床试验10余项。
Prof. Zhong’s main research area involves chronic liver disease, liver fibrosis, inflammatory bowel disease (IBD) and other digestive tract diseases. She established the models of obesity and hyperlipidemia Non-alcoholic steatohepatittis (NASH) in rats in China, and a series of studies were carried out by using this model. In recent years, her team have devoted to revealing the pathogenesis of inflammatory bowel disease and the gut-liver crosstalk, to analyzing new therapeutic targets, and to building up a sample bank of IBD. She also explored the safteness and effectiveness of Mesenchymal stem cell in treatment of Crohn’s Disease, the related articles have been published in EbioMedicine, a lancet publication.
She’s been a PI in a lot of IBD clinical trial and was awarded the third prize of excellent scientific and technological paper of Pudong New Area. She won the 2025“Spring Rising Cup” medical innovation talent competition jointly organized by the Shanghai Municipal Health Commission, Shanghai Municipal Science and Technology Commission, Shanghai Municipal Economic and Credit Commission, Shanghai Intellectual Property Office and Shanghai Food and Drug Administration. She is also the winner of the third prize of Shanghai Medical Science and Technology Award and the Third Prize of Shanghai Science and Technology Progress Award, her work was funded by General Program of National Natural Science Foundation of China, Technology Development Project of Pudong Science, Technology and Economic Commission of Shanghai, Specialty Feature Construction Project of ShanghaiPudong New Area Health Commission and the Scientific research project of Shanghai Municipal Health Committee.
【2021-2025年发表论文】
1. Sun Q, Li S, Lin R, Zhao G, Lu J, Liu B, Hu M, Wang W, Yang X, Wei Y, Jia W, Hu Y, Zhang W, Zhu J, Cui D, Zhong L. hUC-MSCs therapy for Crohn's disease: efficacy in TNBS-induced colitis in rats and pilot clinical study. EBioMedicine. 2024 May;103:105128. doi: 10.1016/j.ebiom.2024.105128. Epub 2024 Apr 22. PMID: 38653187; PMCID: PMC11063396. （1区Top，IF：11.2）(期刊论文)
2. Yang Y, Gu M, Wang W, Li S, Lu J, Sun Q, Hu M, Zhong L. Circulating Bone morphogenetic protein 9 (BMP9) as a new biomarker for noninvasive stratification of nonalcoholic fatty liver disease and metabolic syndrome. Clin Exp Med. 2024 Mar 16;24(1):55. doi: 10.1007/s10238-024-01316-0. PMID: 38492130; PMCID: PMC10944389.(期刊论文)
3. Li S, Zhang F, Lin R, Sun Q, Qu L, Zhong L. Shared Immune Associations Between COVID-19 and Inflammatory Bowel Disease: A Cross-Sectional Observational Study in Shanghai, China. J Inflamm Res. 2024 Mar 27;17:1929-1940. doi: 10.2147/JIR.S449746. PMID: 38558943; PMCID: PMC10981870.(期刊论文)
4. Hu J, Li S, Zhong X, Wei Y, Sun Q , Zhong L. Human umbilical cord mesenchymal stem cells attenuate diet-induced obesity and NASH-related fibrosis in mice. Heliyon. 2024 Feb 1;10(3):E25460, doi:https://doi.org/10.1016/j.heliyon.2024.e25460 (期刊论文)(IF:4/Q2, 通讯作者)
5. Zhuang W, Zhou J, Zhong L, Lv J, Zhong X, Liu G, Xie L, Wang C, Saimaier K, Han S, Shi C, Hua Q, Zhang R, Xie X, Du C. CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation. Cell Death Dis. 2023 Sep 14;14(9):608. doi: 10.1038/s41419-023-06126-y. PMID: 37709757; PMCID: PMC10502121.(IF:9/Q1，中科院1区，共同一作)
6. Zhong X, Li S, Li J, Hu Y, Ma C, Zhong L. Laparoscopic sleeve gastrectomy makes acid reflux symptoms worse or better?: a prospective short-term observational study in patients with morbid obesity. Surg Obes Relat Dis. 2023 May 3:S1550-7289(23)00497-5. doi: 10.1016/j.soard.2023.04.335. Epub ahead of print. PMID: 37277230. (期刊论文)（IF：3.709/Q1，中科院1区，通讯作者）
7. Zhong X , Li S , Hu J, Lu J ,Wang W , Hu M , Sun Q, Zhang S , Yang X , Yang C, Zhong L. Development and external validationof prognostic scoring models for portal veinthrombosis: a multicenter retrospective study. J Thrombosis , 2023, 21:9 https://doi.org/10.1186/s12959-023-00455-w (期刊论文)
8. Li S, Luo Y, Wang W, Lu J, Hu M, Sun Q, Yang X, Han J, Zhong L. A Novel Multiparameter Scoring Model for Noninvasive Early Prediction of Ischemic Colitis: A Multicenter, Retrospective, and Real-World Study. Clin Transl Gastroenterol. 2021 Jun 9;12(6):e00370. doi: 10.14309/ctg.0000000000000370. PMID: 34106095; PMCID: PMC8189633. (期刊论文)（IF：4.488/Q2）
