在国内外专业杂志发表本专业领域内的相关论文87篇(包括SCI收录30篇),以第一作者或通讯作者,发表论文53篇,其中SCI收录的全文论著17篇。荣获包括教育部科技进步奖二等奖、上海市科学技术奖二等奖、上海医学科技奖一等奖等奖项共6项。
主持2项国家自然基金项目和1项上海市自然科学基金面上项目,1项国家自然基金项目已结题(项目批准号:81170398),1项在研国家自然基金项目:MCU在肝细胞死亡、炎症与肝纤维化形成中的关键作用及其作为潜在治疗新靶点的研究。2020-01至2023-12;项目批准号:81970531。1项在研上海市自然基金项目:BAZ2B在NASH相关肝纤维化形成中的作用及其表观遗传机制。2022-04-01至2025-03-31;项目编号:22ZR1448500。
近5年发表主要论文
Li X, Jin Q, Yao Q, Zhou Y, Zou Y, Li Z, Zhang S, Tu C. Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic Macrophage Recruitment and Activation. Front Immunol. 2017; 8:801. doi: 10.3389/fimmu.2017.00801.
Li X, Jin Q, Yao Q, Xu B, Li L, Zhang S, Tu C. The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice. Front Pharmacol. 2018; 9:72. doi:10.3389/fphar.2018.00072.
Li X, Yao Q, Huang J, Jin Q, Xu B, Chen F, Tu C. Morin Hydrate Inhibits TREM-1/TLR4-Mediated Inflammatory Response in Macrophages and Protects Against Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Front Pharmacol. 2019; 10:1089. doi: 10.3389/fphar.2019.01089.
Yao Q, Li S, Li X, Wang F, Tu C. Myricetin Modulates Macrophage Polarization and Mitigates Liver Inflammation and Fibrosis in a Murine Model of Nonalcoholic Steatohepatitis. Front Med (Lausanne). 2020; 7:71. doi:10.3389/fmed.2020.00071
Li S, Li X, Chen F, Liu M, Ning L, Yan Y, Zhang S, Huang S, Tu C. Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction. J Nutr Biochem. 2022;100:108888. doi: 10.1016/j.jnutbio.2021.108888.