聚焦帕金森病及其他运动障碍性疾病的临床与基础研究，主要关注疾病的发病机制、早期诊断及精准治疗。主持国家自然科学基金青年项目（编号：82201404）和上海市卫健委卫生行业临床研究专项（编号：20244Y0148）。以第一作者或通讯作者在 PNAS、Annals of Neurology、Cell Communication and Signaling 等国际知名期刊发表论文10余篇，获授权发明专利1项。研究工作旨在推动运动障碍性疾病从基础机制到临床应用的贯通式研究，为疾病的防治提供新思路与新策略。
I have been devoted to both clinical and basic research on Parkinson’s disease and other movement disorders, with a primary focus on disease pathogenesis, early diagnosis, and precision therapy. I serve as the principal investigator of a Youth Program project funded by the National Natural Science Foundation of China (No. 82201404) and a Clinical Research Grant from the Shanghai Municipal Health Commission (No. 20244Y0148). As the first or corresponding author, I have published more than ten papers in internationally recognized journals, including PNAS, Annals of Neurology, and Cell Communication and Signaling, and hold one authorized invention patent. My research aims to bridge basic mechanisms with clinical applications, advancing potential translational studies of movement disorders and contributing novel insights and strategies for their prevention and treatment.
【代表性论文Representative works】
(1) Zhuoyu Zhang1*; Jingyu Yao1; Jingxiao Huo1; Ruolin Wang; Xueting Duan; Yang Chen; Huadong Xu; Changhe Wang*; Zuying Chai*; Rong Huang*; Action potential-independent spontaneous microdomain Ca2+ transients-mediated continuous neurotransmission regulates hyperalgesia, PNAS, 2025, 122(3): 1-11.
(2) Sha Zhu1; Ronghua Hong1; Zhuang Wu; Yunjun Bao; Yunping Song; Guojiong Hu; Zhongfei Bai; Feifei Zhu; Zhenhua Liao; Lizhen Pan; Qiang Guan; Zhuoyu Zhang*; Lingjing Jin*; Sternocleidomastoid Muscle Overactivity: A Potentially Critical Contributor to Postural Abnormalities in Parkinson's Disease, Annals of Neurology, 2025 Nov; 98(5): 967-976.
(3) Zhuoyu Zhang1*; Rong Huang*; Stronger stimulus triggers synaptic transmission faster through earlier started action potential, Cell Communication and Signaling, 2024, 22(1): 37
(4) Ronghua Hong1; Tianyu Zhang1; Zhuoyu Zhang1; Zhuang Wu; Ao Lin; Xiaoyun Su; Yue Jin; Yichen Gao; Kangwen Peng; Lixi Li; Lizhen Pan; Hongping Zhi; Qiang Guan*; Lingjing Jin*; A summary index derived from Kinect to evaluate postural abnormalities severity in Parkinson’s Disease patients, npj Parkinson's Disease, 2022, 8(96).
(5) Zhuoyu Zhang1; Ronghua Hong1; Ao Lin; Xiaoyun Su; Yue Jin; Yichen Gao; Kangwen Peng; Yudi Li; Tianyu Zhang; Hongping Zhi; Qiang Guan*; Lingjing Jin*; Automated and accurate assessment for postural abnormalities in patients with Parkinson's disease based on Kinect and machine learning, Journal of NeuroEngineering and Rehabilitation, 2021, 18(1): 169.
(6) Zhuoyu Zhang1; Yijue Shen1; Hang Luo; Fen Zhang; Li Jing; Yuanyuan Wu; Xiaofei Xia; Yunping Song; Wei Li*; Lingjing Jin*; MANF protects dopamine neurons and locomotion defects from a human α-synuclein induced Parkinson's disease model in C. elegans by regulating ER stress and autophagy pathways, Experimental Neurology, 2018, 308: 59-71.
