论文发表:
1. Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson's disease. Cui Can, Yingying Han, Hongxia Li, Hongxiang Yu, Bei Zhang and Gang Li. Frontiers in cellular and infection microbiology 2022.
2. Mechanical Thrombectomy for Acute Stroke Due to Large-Vessel Occlusion Presenting With Mild Symptoms. Liu Feifeng, Hao Shen, Chen Chen, Huan Bao, Lian Zuo, Xiahong Xu, Yumei Yang, A. Cochrane, Yaping Xiao and Gang Li. Frontiers in neurology 2021.
3. Stroke Patients with Faster Core Growth have Greater Benefit from Endovascular Therapy. Longting Lin, Hao Zhang, Chushuang Chen, Andrew Bivard, Kenneth Butcher, Carlos Garcia-Esperon, Neil J. Spratt, Christopher R. Levi, Mark W. Parsons, Gang Li. Stroke 2021.
4. High-Density Lipoprotein Cholesterol and the Risk of First Ischemic Stroke in a Chinese Hypertensive Population. Yue Zhang,Jingyi Li, Chengzhang Liu, Hongxiang Yu,Chen Chen,Chonglei Bi, Chongqian Fang, Hai Ma,Aimin Li,Qing Dong, Lishun Liu,Binyan Wang, Xiao Huang, Xiaoshu Cheng, Pierre Zalloua,Xiping Xu, Yong Huo, and Gang Li. Clinical Interventions in Aging,2021,05
5. Association of HMOX-1 with sporadic Alzheimer’s disease in southern Han Chinese. Bei Zhang, Hong-Xiang Yu, Nan Zhi, Can Cui, Ying-Ying Han, Min Hu, Hao Shen, Huan Bao, Gang Li. European Journal of Neurology, 2021.
6. Increased GABAergic Development in iPSC-Derived Neurons from Patients with Sporadic Alzheimer’s Disease, Yueyu Tang, Yingying Han, Hongxiang Yu, Bei Zhang, and Gang Li. Neuroscience Letters,2020,06
7. Association between ZNF184 and symptoms of Parkinson's disease in southern Chinese. Zhang B, Cui C, Yu H, Li G. Neurol Sci. 2020 Mar 3. doi: 10.1007/s10072-020-04309-5.
8. Association between fatigue and motor progression in Parkinson's disease in southern Chinese. Yu HX, Guo MR, Li G, Zhang B. Neurol Sci. 2020 Jan;41(1):161-164. Epub 2019 Sep 4
9. Therapeutic Effect on Acute Cerebral Infarction is Enhanced after Nanoceria-Labeling on Human Umbilical Cord Mesenchymal Stem Cells. Zuo L, Feng Q, Han Y, Chen M, Guo M, Liu Z, Cheng Y, Li G. Therapeutic Advances in Neurological Disorders, 2019 Jul 30;12:1756286419859725.
10. Clinical and laboratory factors related to acute isolated vertigo or dizziness and cerebral infarction. Zuo L, Zhan Y, Liu F, Chen C, Xu L, Calic Z, Cordato D, Cappelen-Smith C, Hu Y, Li G. Brain Behav. 2018, 8:e01092.
11. Establishment of TUSMi003-A, an induced pluripotent stem cell (iPSC) line from a 62-year-old Chinese Han patient with Alzheimer's disease with ApoE3/4 genetic background. Wang Y, Yu H, Zhang Y, Zhang J, Chen K, Sun H, Meng S, Li G, Lei Y, Zhao J. Stem Cell Res. 2018, 27:57-60.
承担的主要课题:
(一)在研:
外源性和内源性干细胞的多模示踪及评价,科技部国家重点研发计划,项目编号:2018YFA010790,课题主干,2018.07至2022.12;2632万
EphrinB3介导神经干细胞增殖分化对阿尔茨海默病发病及相关机制, 国家自然科学基金(面上项目),82071192,2021.01至2024.12,55万;
SV2A配体调控阿尔茨海默病关键神经免疫细胞功能的作用及其机制研究,国家自然科学基金(面上项目),81870843,2019年1月至2022年12月,56万;
利用诱导转分化的人神经前体细胞治疗AD的临床研究,张江国家自主创新示范区干细胞转化医学产业基地项目,临床研究负责人(基础研究负责人:裴钢 院士);
人脐带间充质干细胞治疗急性缺血性脑卒中的临床研究,张江国家自主创新示范区干细胞转化医学产业基地项目,临床研究负责人(基础研究负责人:时玉舫 教授);
卒中超急性期院前降压研究前瞻性随机多中心终点盲法的平行研究(INTERACT4),注册号NCT03790800,与乔治全球健康研究院为共同PI单位
(二)已结题:
神经系统和心脏相关重大疾病组织干细胞和病理组织库,科技部国家重点研发计划,课题组组长;项目编号:2016YFA0101300;负责课题《神经系统和心脏相关重大疾病病理组织库》,序号:2016YFA0101301;2016.07至 2021.07,732万;
面向阿尔茨海默病的社区可穿戴实时监测网络建立与应用研究,上海市科委重大项目,16511105000,主持,2016.07至2018.06;
SV2A配体抑制CD8+T淋巴细胞脱颗粒对急性脑缺血神经保护作用研究,国家自然科学基金(面上项目),81271289,第一申请人, 2013.1至2016.12。
Ongoing Research Projects:
1) Tissue repair and functional reconstruction of clinical tracer transplanted stem cells, National Key Research and Development Program of the Ministry of Science and Technology, backbone of the subject, 2018YFA0107903, 2018/07-2022/12
2) EphrinB3 mediates the proliferation and differentiation of neural stem cells on the pathogenesis and related mechanisms of Alzheimer's disease, National Natural Science Foundation of China, 82071192, 2021/01-2024/12
3) The role and mechanism of SV2A ligand in regulating the functions of key neuroimmune cells in Alzheimer's disease, National Natural Science Foundation of China 8187084, 2019.01 to 2022.12
4) Clinical research on the use of induced transdifferentiated human neural precursor cells to treat AD, Zhangjiang National Independent Innovation Demonstration Zone Stem Cell Translation Medicine Industrial Base Project, clinical research leader (Research leader: Academician Pei Gang)
5) Clinical research on human umbilical cord mesenchymal stem cells in the treatment of acute ischemic stroke, Zhangjiang National Independent Innovation Demonstration Zone Stem Cell Translation Medicine Industrial Base Project, clinical research leader (Research leader: Professor Shi Yufang)
6) A prospective randomized multicenter blinded parallel study of prehospital blood pressure study in the hyperacute phase of stroke (INTERACT4), NCT03790800
Finished Projects:
1) Pathological tissue bank for major diseases related to the nervous system and heart", Ministry of Science and Technology of China ,2016YFA0101301,2016.07 /2021.07;
2) Research on the establishment and application of community wearable real-time monitoring network for Alzheimer's disease, Shanghai Science and Technology Commission, 16511105000, 2016.07/ 2018.06
3) SV2A ligand inhibits the neuroprotection of CD8+ T lymphocyte degranulation on acute cerebral ischemia, National Natural Science Foundation of China ,81271289, first applicant, 2013.1 /2016.12,