消化道及腹盆部疾病影像诊断及分子影像（CT、MRI、SPECT、PET-CT）、介入治疗、人工智能医工交叉研究 Imaging diagnosis and molecular imaging (CT MRI、SPECT、PET-CT）、 Interdisciplinary research on interventional therapy and artificial intelligence in medical engineering

中国医药教育学会肝胆智能装备发展促进分会常务委员（2024），中国医师协会核医学医师分会第五届委员会智能影像与动态定量学组组员（2024），中国影像研究会第六、七届放射委员会委员（2020、2023），上海市中西医结合学会第二届核医学分会委员（2023），中华医学会放射学分会第十六届对比剂使用及安全工作组委员兼秘书（2022），2019年中国医促会放射学分会会员（2019），海峡两岸医药卫生交流协会第一届放射学专业委员会委员（2018），上海市生物医学工程学会放射医学工程专业委员会会员（2018），中华放射学分会第十四届介入专委会综合介入组委员（2016）。

Executive member of the Liver and Gallbladder Intelligent Equipment Development Promotion Branch of the Chinese Medical Education Association (2024), member of the Intelligent Imaging and Dynamic Quantification Group of the 5th Committee of the Nuclear Medicine Physician Branch of the Chinese Medical Association (2024), member of the 6th and 7th Radiology Committees of the Chinese Imaging Research Association (2020, 2023), member of the 2nd Nuclear Medicine Branch of the Shanghai Society of Integrated Traditional Chinese and Western Medicine (2023), member and secretary of the 16th Contrast Agent Use and Safety Working Group of the Radiology Branch of the Chinese Medical Association (2022), member of the Radiology Branch of the Chinese Medical Promotion Association in 2019 (2019), member of the 1st Radiology Professional Committee of the Cross Strait Medical and Health Exchange Association (2018), and member of the Radiology Engineering Professional Committee of the Shanghai Biomedical Engineering Society (2018), Member of the Comprehensive Intervention Group of the 14th Interventional Committee of the Chinese Radiology Society (2016).

承担及参与课题（Undertake and participate in the project）：

1、上海市创新医疗器械应用示范项目/uAngio 960肿瘤介入示范培训体系建立/23SHS01300-03，2023/12-2026/11，20万元，第二参与（子课题）上海市经信委/医用血管造影X射线机应用示范项目，23SHS01300，100万元，中山医院。Shanghai Innovative Medical Device Application Demonstration Project, uAngio 960 Tumor Intervention Demonstration Training System Establishment/23HS01300-03, 2023/12-2026/11, 200000 yuan, Second participant (sub project) Shanghai Municipal Commission of Economy and Information Technology/Medical Angiography X-ray Machine Application Demonstration Project, 23HS01300, 1 million yuan, Zhongshan Hospital

2、院级课题，“EXO-ICG-碘”介入成像诊疗结直肠肝转移瘤的实验研究，RCQD2406，2024/10-2027/9，50万元，主持。Research on the Experimental Study of "EXO-ICG Iodine" Interventional Imaging Diagnosis and Treatment of Colorectal Liver Metastasis at the Hospital Level, RCQD2406,2024/10-2027/9, RMB 500000. Leader

3、2019年度申康临床科技创新（新兴前沿）项目，SHDC12019122，光动力联合食管支架治疗食管恶性梗阻多中心临床研究，2019/11-2023/11，50万元，第二，已结题。The 2019 Shenkang Clinical Technology Innovation (Emerging Frontier) Project, SHDC12019122, is a multicenter clinical study on photodynamic therapy combined with esophageal stent for the treatment of malignant esophageal obstruction. RMB 500000, 2019/11- 2023/11. Second participant. Completed.

4、上海市科学技术委员会，19411971800，脊柱转移癌诊治体系的优化及新兴介入治疗技术的临床应用研究，2019/3-2022/3，20万，第二，已结题。Shanghai Municipal Commission of Science and Technology, 19411971800, Optimization of Diagnosis and Treatment System for Spinal Metastatic Cancer and Clinical Application Research of Emerging Interventional Treatment Technologies, 2019/3-2022/3, RMB200000, Second participant. Completed.

5、上海领军人才培养计划，2019/1-，110万元，团队成员之一，课题第二参与人，在研。The Shanghai Leading Talent Training Program, 2019/1-, RMB1.1 million, one of the team members and the second participant in the project.Currently under research.

6、院特色专业，肝肾囊肿的CT介入硬化治疗，2019/01-2020/12，6万，主持，已验收。Featured specialty of the hospital, CT interventional sclerotherapy for liver and kidney cysts, 2019/01-2020/12, RMB60000. Leader. Completed and accepted.

7、上海市科学技术委员会，18ZR1429400，多模态消融联合经皮椎体成形术治疗骨转移瘤的作用及免疫应答机制研究，2018/6-2021/5，20万，第二，已结题。Shanghai Municipal Commission of Science and Technology, 18ZR1429400, Study on the Effect and Immune Response Mechanism of Multimodal Ablation Combined with Percutaneous Vertebroplasty in the Treatment of Bone Metastasis, 2018/6-2021/5, RMB200000, Second participant. Completed.

8、国家自然科学基金面上项目，81771943，仿生食管水凝胶复合纤维支架治疗食管瘘的实验研究，2018/01-2019/12，25万元，第二，已结题。General Project of National Natural Science Foundation of China, 81771943, Experimental Study on Treatment of Esophageal Fistula with Biomimetic Esophageal Hydrogel Composite Fiber Stent, 2018/01-2019/12, RMB250000. Second participant. Completed.

9、2017年科技部国家重点研发计划数字诊疗装备研发重点专项（子课题），2017YFC0109204 ，基于锥束CT和灌注技术在脑血管介入治疗中的整合解决方案的研究，2017/07-2021/12，90.05万，第三，已结题。Key Special Project for Digital Diagnosis and Treatment Equipment Research and Development under the 2017 National Key R&D Program of the Ministry of Science and Technology (sub project), 2017YFC0109204, Research on Integrated Solution Based on Cone Beam CT and Infusion Technology in Cerebrovascular Intervention Therapy, 2017/07-2021/12, RMB 9000500. Third participant. Completed.

10、2016年上海市卫生和计划生育委员会科研课题面上项目，201640191，血清VEGF-C联合MR扩散加权成像对结直肠癌区域淋巴结转移的诊断价值，2017/01-2019/12，10万元，主持，已结题。The General Research Project of Shanghai Municipal Health and Family Planning Commission in 2016, 201640191, focuses on the diagnostic value of serum VEGF-C combined with MR diffusion-weighted imaging for regional lymph node metastasis in colorectal cancer. 2017/01-2019/12, RMB100000. Leader. Completed.

11、上海市医学领军人才培养计划，具有光敏剂纳米颗粒控释功能的可降解镁合金支架治疗食管恶性梗阻的实验研究，2016/1-2019/12，45万元，第二，已结题。The experimental study on the treatment of malignant esophageal obstruction with degradable magnesium alloy stent with photosensitizer nanoparticle controlled release function under the Shanghai Medical Leading Talent Training Program, 2016/01-2019/12. RMB450000 . Second participant. Completed.

12、国家自然科学基金面上项目，81571773，具有光敏剂纳米颗粒控释功能的可降解镁合金支架治疗食管恶性梗阻的实验研究，2016/01-2019/12，69.6万元，第二，已结题。National Natural Science Foundation of China General Project, 81571773, Experimental study on the treatment of malignant esophageal obstruction with degradable magnesium alloy stent with photosensitizer nanoparticle controlled release function, 2016/01-2019/12, RMB696000. Second participant. Completed.

第一作者或通讯作者发表的论文（Papers published by the first author or corresponding author）:

1.Yingying Yang; Jinrong Situ; Kai Yang*; Yingsheng Cheng*. A Novel Nanocatalyst for Combined Chemodynamic and Starvation Therapy in Cancer Treatment. Bioorganic & Medicinal Chemistry, 2024, ACCEPT.

2.Yining Tao, Chenxu Yan, Yue Wu, Dan Li, Juan Li, Yuchen Xie, Yingsheng Cheng, Yisheng Xu, Kai Yang*, WeiHong Zhu, Zhiqian Guo*. Uniting Dual-Modal MRI/Chemiluminescence Nanotheranostics: Spatially and Sensitively Self-Reporting Photodynamic Therapy in Oral Cancer, Advanced Functional Materials （2023, IF=19.00, Q1）

3.Yue Du, Yan Chen, Cai-hong Li, Bi Zhou, Jin-liang Wu, Liang-rui Gu, and Kai Yang*. Diagnostic Value of CT Window Technique for Primary Omentum Infarction. Computational and Mathematical Methods in Medicine, 2022, doi.org/10.1155/ 2022/ 4173738.3.（2022, IF=2.28, Q2）

4.Zhou Bi, Yi Fei, Chen Yan，Li Cai-hong，Cheng Ying-sheng，Yang Kai*. Reduced long noncoding RNA PGM5-AS1 facilitated proliferation and invasion of colorectal cancer through sponging miR-100-5p. European Review for Medical and Pharmacological Sciences. 2020; 24: 7972-7981.（2019，IF=3.024；Q2）

5.Kai Yang, Bi Zhou,Fei Yi, Yan Chen, Yingsheng Cheng. Colorectal Cancer Diagnostic Algorithm Based on Sub-Patch Weight Color Histogram in Combination of Improved Least Squares Support Vector Machine for Pathological Image. Journal of Medical Systems, 2019 Aug 14;43(9):306. doi: 10.1007/s10916-019-1429-8.(2018, SCI, IF=2.415，Q1)

6.Kai Yang, Jun Cao, Tian-Wen Yuan, Yue-Qi Zhu, Bi Zhou, Ying-Sheng Cheng. Silicone-covered biodegradable magnesium stent for treating benignesophageal stricture in a rabbit model. World Journal of Gastroenterology, 2019,25（25）：3207-3217(2018, SCI, IF=3.411，Q2)

7.Kai Yang, YueQi Zhu, Ni-Wei Chen, Zhi-Gang Wang, Ying-Sheng Cheng. Super Flexible Through-the-Scope Self-Expandable Metallic Stent Insertion for the Management of Malignant Tortuous Hepatic or Splenic Flexure Colonic Obstruction, Chinese Medical Journal, 2018；131(11):1381-1384 (2018, SCI, IF=1.555，Q1)

8.Yueqi Zhu, Kai Yang, Ruoyu Cheng, Yi Xiang, Tianwen Yuan,Bruno Sarmento, Yingsheng Cheng and Wenguo Cui. The current status of biodegradable stent to treat benign luminal disease. Materials Today. 2017, http://dx.doi.org/ 10.1016/j.mattod.2017.

05.002.(2017, SCI, IF=24.537, 共同第一作者，Q1).

9.Kai Yang, Ying-Sheng Cheng, Ji-Jin Yang, Xu Jiang and Ji-Xiang Guo. Primary hepatic neuroendocrine tumors:multi-modal imaging features withpathological correlations. Cancer imaging. 2017 Jul 6; 17(1):20. doi: 10.1186/s40644- 017-0120-x. (2017, SCI, IF=3.016，Q1)

10.Yueqi Zhu, Kai Yang, Yingsheng Cheng. Silicon-Covered Biodegradable Magnesium Stent Insertion in the Esophagus: A comparion with Plastic Stents. Therapeutic Advances in Gastroenterology.2017; 10(1):11-19 (SCI, IF 3.883, Q2)

11.陈燕，方统磊，田庆华，吴金亮，顾梁瑞，吴春根，杨凯*。恶性胆道梗阻引流前后的胆道微生物群改变初步研究。介入放射学杂志，2024，33(5): 483-489。

12.黄志龙，张深燕，方统磊，田庆华，吴金亮，顾梁瑞，吴春根，杨凯*。CT引导下聚桂醇硬化治疗肾囊肿。介入放射学杂志，2023，32(11): 1115-1118。

13.李彩红，杨凯*，周碧，吴春根。CT窗宽技术对原发性大网膜梗死的诊断价值，医学影像学杂志，2022；32(2): 273-275，280。

14.黄志龙，田庆华，周碧，张开华，王建波，吴春根，杨凯*。肝多发腺瘤1例诊疗分析。介入放射学杂志，2021，30(12): 1233-1235。

15.周碧，张开华，吴春根，杨凯*。肠系膜脂膜炎多层螺旋CT表现，中华实用诊断与治疗杂志，2018；32 (6): 586-588。

16.陈燕，周碧，申玉兰，吴春根，杨凯*。肝脏局灶性结节增生的多层螺旋CT和MRI表现及病理基础. 中华实用诊断与治疗杂志，2017；31(12): 1217-1219。

17.杨凯，朱悦琦，苑天文，等。硅膜-镁合金可降解支架置入兔食管可行性及组织反应——体外和体内初步研究. 介入放射学杂志. 2017；26(9): 818-822。