一、课题情况：主持八项国家及军队课题，参与多项国家及军队重大课题，现主持的在研课题经费600余万元。
1. 基于多维影像大数据智能分析的肝癌个体化微波消融治疗研究，科技部重大专项，2018ZX10723-204，566.66万元，主持，在研
2. 基于多模态影像三维导航系统的粒子植入自动化布源规则及方法研究，国家自然科学金，81671710，58万元，主持，在研
3. 超声引导三维可视化导航粒子植入治疗系统研发及应用研究，国家自然科学金，81471683，72万元，主持，已结题
4.
原发性肝细胞癌微灌注及弹性模量状态与复发机制研究，国家自然科学金，81171358，58万元，主持，已结题
5.
基于无创技术的胰腺癌早期诊断的方法学流程及超声检查操作规范，军队重点专项，12BJZ36，30万，主持，已结题
Research projects: In charge of eight national and military projects, participating
in many national and military major projects, and in charge of more than six
million RMB for current projects.
1. Study
on individualized microwave ablation of liver cancer based on multi-dimensional
image big data intelligent analysis. National Science and Technology Major
Project. 2018ZX10723-204, 5.67 million RMB, in charge, in research.
2. Research
on automatic source distribution rules and methods of particle implantation
based on multimodal image 3D navigation system. National Natural Science
Foundation of China. 81671710, 0.58 million RMB, in charge, in research.
3. Research
and application of ultrasound-guided three-dimensional visualization navigation
particle implantation therapy system. National Natural Science Foundation of
China. 81471683, 0.72 million RMB, in
charge, already concluded.
4. Study
on the state of perfusion and elastic modulus and the mechanism of recurrence
of primary hepatocellular carcinoma. National Natural Science Foundation of
China. 81171358,
0.58 million RMB, in charge, already concluded.
5. The
methodology flow and standard of ultrasonic examination for early diagnosis of
pancreatic cancer based on noninvasive technology. Military Major Project. 12BJZ36, 0.3
million RMB, in charge, already concluded.
二、文章发表：发表文章近200篇，其中培养的研究生（本人作为通讯作者）发表SCI收录论文24篇，单篇最高影响因子19.791（Advanced Materials , 2019年IF为25.81）。
Articles: Nearly 200 articles have been published, 24 of which are
written by the postgraduates, titled Yu Xiaoling as the corresponding author.
The highest influence factor is 19.791 (Advanced Materials, IF is 25.81 in
2019).
1 Hu Y, Chi C,
Wang S, Wang L, Liang P, Liu F, Shang W, Wang W, Zhang F, Li S, Shen H, Yu X*,
Liu H, Tian J.A
Comparative Study of Clinical Intervention and Interventional Photothermal
Therapy for Pancreatic Cancer.Adv Mater. 2017
Sep;29(33).
2 Zhan Y, Zhou F, Yu X*, Luo F, Liu F, Liang P, Cheng Z,
Han Z, Yu J. Quantitative dynamic contrast-enhanced ultrasound may help predict
the outcome of hepatocellular carcinoma after microwave ablation. Int J
Hyperthermia. 2019 Jan 1;35(1):105-111.
3 Li H, Li J, Zhan Y, Han Z, Liu F, Liang P, Yu X*.
Ultrasound-Guided 125I Seed Implantation in Treatment of Abdominal Wall
Metastases. Cancer Biother Radiopharm. 2019
May;34(4):218-223.
4 Hu Y, Qi E, Liu F, et al. The application of a three-dimensional
visualized seed planning and navigation system in125I seed implantation for
pancreatic cancer:[J]. Oncotargets Therapy, 2018, 11:619.
5 Zhou F, Shang W, Yu X, et al. Glypican‐3: A promising biomarker
for hepatocellular carcinoma diagnosis and treatment[J]. Medicinal Research
Reviews, 2017, 38(5).
6
Zhou F, Yu XL, Liang P, Cheng Z, Han ZY, Yu J, Liu F, Hu Y.
Microwave ablation is effective against liver metastases from gastric
adenocarcinoma. Int J Hyperthermia. 2017
Nov;33(7):830-835
7
Tan SL, Yu XL, Liang P, Liu F, Cheng Z, Han ZY, Yu J. Preventing intrahepatic infection after ablation of liver tumours in
biliary-enteric anastomosis patients. Int J Hyperthermia. 2017 Sep;33(6):664-669.
8
Zhou F, Yu X, Liang P, Han Z, Cheng Z, Yu J, Liu
F, Hu Y. Does primary tumor location impact the prognosis of
colorectal liver metastases patients after microwave ablation? - Lessons from
10 years' experience. Oncotarget. 2017 Jun 28;8(59); 100791-100800
9
Sun Y, Zhou F, Liu F, Hu Y, Tan S, Liang P,
Linghu E, Yu X. Discrimination of serous cystadenoma from mucinous cystadenoma
in the pancreas with contrast-enhanced ultrasonography: a prospective study in
61 patients. Onco Targets Ther. 2017 Feb 28;10:1285-1294.
10
Zhou F, Yu X, Liang P, Cheng Z, Han Z, Yu J, Liu
F, Tan S, Dai G, Bai L. Combined microwave ablation and systemic chemotherapy for
liver metastases from oesophageal cancer: Preliminary results and literature
review. Int J
Hyperthermia. 2016;32(5):524-30.
11
Li M, Li Z, Yu X, Liang P, Gao Y, Han Z, Liu F,
Dong J. Percutaneous radio-frequency ablation of hepatocellular
carcinoma adjacent to the gastrointestinal tract. Int J
Hyperthermia. 2016;32(6):600-6.
12
Li M, Yu X, Liang P, Dong
B, Liu F. Ultrasound-guided percutaneous microwave ablation for hepatic
malignancy adjacent to the gallbladder. Int J Hyperthermia. 2015 Sep;31(6):579-87.
13
Wei Y, Yu
XL, Liang P, Cheng ZG, Han ZY, Liu FY, Yu J. Guiding and controlling
percutaneous pancreas biopsies with contrast-enhanced ultrasound:
target lesions are not localized on B-mode ultrasound. Ultrasound Med
Biol. 2015 Jun;41(6):1561-9
14
Zhang
D, Xie D, Wei X, Zhang D, Chen M, Yu X, Liang P. Microwave ablation of the liver abutting the stomach: insulating effect
of a chitosan-based thermosensitive hydrogel.Int J Hyperthermia. 2014 Mar;30(2):126-33.
15
Liu
LP, Yu XL, Liang P, Dong BW. Characterization of primary hepatic carcinosarcoma by contrast-enhanced
ultrasonography: a case report.
World J Gastroenterol.
2014 Feb 14;20(6):1630-4.
16
Cao
XL, Li H, Yu XL, Liang P, Dong BW, Fan J, Li M, Liu FY. Predicting early intrahepatic recurrence of hepatocellular carcinoma
after microwave ablation using SELDI-TOF proteomic signature. PLoS One. 2013 Dec 13;8(12):e82448.
17
Zhang
D, Liang P, Yu X, Cheng Z, Han Z, Yu J, Liu F. The value of artificial pleural effusion for percutaneous microwave
ablation of liver tumour in the hepatic dome: a retrospective case-control
study.Int J
Hyperthermia. 2013 Nov;29(7):663-70.
18
Qu
P, Yu X, Liang P, Cheng Z, Han Z, Liu F, Yu J. Contrast-enhanced ultrasound in the characterization of hepatocellular
carcinomas treated by ablation: comparison with contrast-enhanced magnetic
resonance imaging.
Ultrasound Med Biol.
2013 Sep;39(9):1571-9.
19
Li
M, Yu XL, Liang P, Liu F, Dong B, Zhou P. Percutaneous microwave ablation for liver cancer adjacent to the
diaphragm. Int J Hyperthermia.
2012;28(3):218-26.
20
Liu
FY, Yu XL, Liang P, Cheng ZG, Han ZY, Dong BW, Zhang XH. Microwave ablation assisted by a real-time virtual navigation system for
hepatocellular carcinoma undetectable by conventional ultrasonography.Eur J Radiol. 2012
Jul;81(7):1455-9.
21
Qi
C, Yu XL, Liang P, Cheng ZG, Liu FY, Han ZY, Yu J. Ultrasound-guided microwave ablation for abdominal wall metastatic
tumors: a preliminary study.
World J Gastroenterol.
2012 Jun 21;18(23):3008-14.
22
Liu
F, Yu X, Liang P, Cheng Z, Han Z, Dong B. Contrast-enhanced ultrasound-guided microwave ablation for hepatocellular
carcinoma inconspicuous on conventional ultrasound. Int J Hyperthermia. 2011;27(6):555-62.
23
Liu
FY, Yu XL, Liang P, Wang Y, Zhou P, Yu J. Comparison of percutaneous 915 MHz microwave ablation and 2450 MHz
microwave ablation in large hepatocellular carcinoma. Int J Hyperthermia. 2010;26(5):448-55.
24
Liu
LP, Dong BW, Yu XL, Liang P, Zhang DK, An LC. Focal hypoechoic tumors of Fatty liver: characterization of conventional
and contrast-enhanced ultrasonography.J
Ultrasound Med. 2009 Sep;28(9):1133-42.
三、主编书籍：
受人民卫生出版社特邀主编首部介入超声学科建设示范教材“介入超声学科建设与规范”，副主编示范教材“中华介入超声学”；受Springer出版社特邀，主编英文教材“微波消融治疗实体肿瘤”。
Editing Books:
The first demonstration textbook for interventional ultrasound:
Construction and Standardization of Interventional Ultrasound. People’s Medical
Publishing House.
English textbook: Microwave Ablation Treatment of Solid Tumors.
Springer Publishing House.
四、获奖情况：
1. 2014年获国家技术发明二等奖（第二完成人），题目：微波消融设备的研发与临床应用。
2. 2012年获中华医学科技二等奖（第二完成人），题目：微波消融多脏器实体肿瘤的技术创新及应用。
3. 2012年获北京市科学技术二等奖（第二完成人），题目：提升微波消融新平台-水冷微波消融系统的研发及其临床应用。
4. 2004年获国家科学技术进步二等奖（第三完成人），题目：可控球形热场介入式微波治疗肿瘤技术及肝癌治疗疗效。
5. 2015年获实用新型专利一项，名称：一种用于介入手术的电磁定位导航粒子植入套针。
6. 2011年获国家发明专利一项，名称：微波消融针及其微波消融治疗仪。
7. 2009年获国家发明专利一项，名称：微波功率源及其微波消融治疗仪。
8. 2008年获实用新型专利一项，名称：用于915MHz的聚能微波消融针。
Awards:
1. Second prize of national technological invention, 2014, title: Development
and clinical application of microwave ablation equipment.
2. Second prize of Chinese medical science and technology, 2012,
title: Technical innovation and application of microwave ablation of solid
tumors in multiple organs.
3. Second prize of science and technology of Beijing, 2012, title:
Development and clinical application of water cooling microwave ablation system.
4. Second prize of national science and Technology Progress Award,
2004, title: Microwave treatment of tumor and therapeutic effect of liver
cancer with controllable spherical thermal field.
5. Patent for Utility Model, 2015, title: An electromagnetic
positioning and navigation particle implantation trocar for interventional
surgery.
6. National invention patent, 2011, title: Microwave ablation
needle and its instrument.
7. Patent for Utility Model, 2009, title: Microwave power source
and its ablation instrument.
8. National invention patent, 2008, title: Focused energy
microwave ablation needle for 915MHz.
五、学生培养：
共招收培养研究生26名，目前在读5名。培养的研究生多被北京各三甲医院录取，部分已经成为全国知名的介入超声青年专家，获得北京市优青人才项目、国科金面上和青年基金项目等。其中胡琰琰博士论文（题目：碘125粒子植入治疗及介入式光热治疗在胰腺癌治疗中的研究应用）获得2017年“全军优秀博士论文”，且该研究成果以封面文章发表于一区杂志Advanced Materials （IF：19.791 , 2019年IF为25.81）；周福波博士在读研究成果以第一或共同第一作者发表SCI论文9篇，总影响因子37.4；多名研究生在读期间曾一次或多次获“优秀学员”称号。培养的研究生积极参加学术大会并英文发言，同时多次为知名外宾担任大会同声传译工作。
Postgraduate Education
Yu
Xiaoling has recruited 26 postgraduates in total, and five of them are being at
school. Most postgraduates have been employed by many hospitals in Beijing.
Some of them have become national famous young experts of interventional
ultrasound, acquired Beijing Excellent Youth Talent Project, General program of
NSFC and Youth Fund Project of NSFC. Dr. Hu Yanyan’s doctoral dissertation,
titled A Comparative Study of Clinical Intervention and Interventional
Photothermal Therapy for Pancreatic Cancer, has won the prize of Excellent
Doctoral Dissertation of the Whole Army in 2017. Moreover, her research
findings have been published on Advanced Materials. Dr. Zhou Fubo has successfully
published nine articles as the first or co-first author, the summed IF of which
has reached 37.4. Many postgraduates once won the honorary title of outstanding
student for one or more times when at college. The postgraduates attended many
conferences and made speeches positively. Meanwhile, they worked as simultaneous
interpreters for several times.
