病原微生物快速检测和耐药机制研究Rapid detection of pathogenic microorganisms and drug resistance mechanism

同济大学附属东方医院南院医学检验科主任,中国女医师协会检验医学分会副主任委员、中华医学会检验医学分会临床微生物学组委员、上海市微生物学会临床微生物学专委会主任委员、上海市医学会分子诊断分会感染病学组组长、上海市医学会检验医学分会微生物学组组长、中国合格评定国家认可委员会主任评审员。

Director of the Department of Laboratory Medicine, Southern Branch of East Hospital Affiliated to Tongji University, Vice Chairman of the Laboratory Medicine Branch of the Chinese Association of Women Physicians, Member of the Clinical Microbiology Group of the Laboratory Medicine Branch of the Chinese Medical Association, Chairman of the Clinical Microbiology Committee of the Shanghai Microbiology Society, Head of the Infectious Diseases Group of the Molecular Diagnostics Branch of the Shanghai Medical Association, Head of the Microbiology Group of the Laboratory Medicine Branch of the Shanghai Medical Association, and Chief Reviewer of the China National Accreditation Committee for Conformity Assessment.

负责主持国家科技重大专项、上海市公共卫生重点学科、国家自然科学基金等纵向课题20余项，入选上海市优秀技术带头人、上海市卫生系统优秀学科带头人、浦东新区学科带头人，发表SCI和核心期刊论文100余篇、主编专著4部，申请专利8项。荣获全国卫生健康系统新冠肺炎疫情防控工作先进个人和中国女医师协会最美抗疫巾帼人物奖励。

Undertook more than 20 projects including National Science and Technology Major Projects, Shanghai Key Discipline of Public Health, National Natural Science Foundation of China, etc., selected as Shanghai Excellent Technology Leader, Shanghai Health System Excellent Discipline Leader, Pudong New Area Discipline Leader, and published 100 academic papers, chief-edited 4 professional books, and applied for 8 patents. The national advanced individual in the prevention and control of COVID-19 in the National Health System and the most beautiful Anti-COVID-19 woman award by the Chinese Women Physicians Association.

Representative paper:1.Zhang M, Wang L, Yu S, Sun G, Lei H, Wu W. Status of occupational protection in the COVID-19 Fangcang Shelter Hospital in Wuhan, China. Emerg Microbes Infect. 2020;9(1):1835-1842.

2.Lin Q, Wen D, Wu J, Liu L, Wu W*, Fang X*, Kong J*. Microfluidic Immunoassays for Sensitive and Simultaneous Detection of IgG/IgM/Antigen of SARS-CoV-2 within 15 min. Anal Chem. 2020 Jul 21;92(14):9454-9458.

3.Zhou A, Li J, Xu Z, Ni J, Guo J, Yao YF, Wu W. Whole-Genome Comparative and Pathogenicity Analysis of Salmonella enterica subsp. enterica Serovar Rissen. G3 (Bethesda). 2020 Jul 7;10(7):2159-2170.

4.Zhu C, Yu S, Zhao H, Shen H, Yang J, Zhao L, Wu W. Neutrophil-to-lymphocyte ratio predicts the clearance of SARS-CoV-2 RNA in mild COVID-19 patients- a retrospective analysis from Dongxihu Fangcang Hospital in Wuhan, China. Clin Chem Lab Med. 2020 Jul 1;58(9):e167-e170.

5.Guo W, Kuang Y, Wu J, Wen D, Zhou A, Liao Y, Song H, Xu D, Wang T, Jing B, Li K, Hu M, Ling J, Wang Q and Wu W. (2020) Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma. Front. Oncol. 10:52.doi: 10.3389/fonc.2020.00052

6.Sun Y, Guo J, Chen R, Hu L, Xia Q, Wu W*, Wang J, Hu F.Multicenter evaluation of three different MALDI-TOF MS systems for identification of clinically relevant filamentous fungi. Med Mycol. 2020 May 21:myaa037.

7.Liu JL, Li TM, Zhong N, Wang X, Jiang J, Zhang WX, Tang R, Guo YJ, Liu Y, Hu J, He LH, Tang J, Wu WJ*, Li M.Current status of oxacillin-susceptible mecA-positive Staphylococcus aureus infection in Shanghai, China: A multicenter study. J Microbiol Immunol Infect. 2020 Aug 7:S1684-1182.

8.Lingyun Ji, Aiping Zhou, Xiaoyu Yu , Zhenghua Dong , Huaping Zhao , Hui Xue , Wenjuan Wu, Differential expression analysis of the SRB1 gene in fluconazole-resistant and susceptible strains of Candida albicans, J Antibiot (Tokyo). 2020 May;73(5):309-313.

9.Guo, Wenzheng; Hu, Min; Wu, Jingjing; Zhou, Aiping; Liao, Yueling; Song, Hongyong; Xu, Dongliang; Kuang, Yanbin; Wang, Tong; Jing, Bo; Li, Kaimi;; Ling, Jing; Wen, Donghua ;Wu, Wenjuan * Gprc5a depletion enhances the risk of , smoking-induced lung tumorigenesis and mortality ,Biomedicine & Pharmacotherapy , 114 (2019) 108791.

10.Wang H, Wang Y, Yang QW, Ni YX, Lin LK, Luo YP, Sun ZY, Li M, Wu WJ, Zhang QQ, Su DH, Yu H, Kang M, Xu HP, Liu W, Yang Q, Jian C, Guo LN, Yang WH, Xiao M, Hsueh PR, Xu YC. A national survey on fungal infection diagnostic capacity in the clinical mycology laboratories of tertiary care hospitals in China. J Microbiol Immunol Infect. 2020 Mar 27:S1684-1182.

11.Yuetian Yu#, Cheng Zhu#, Hui Shen, Chunyan Liu, Ruru Guo, Yuan Gao, Wenjuan Wu*, Liangjing Lu*, Galactomannan detection in bronchoalveolar lavage fluid corrected by urea dilution for the diagnosis of invasive pulmonary aspergillosis among nonneutropenic patients, Journal of Thoracic Disease, 2018, 11(2): 465-476.

12.Xiaoyu Yu#, Fei Fu#, Wenna Kong, Qiankun Xuan, Donghua Wen, Xiaoqing Chen, Yong-Ming He, Li-Hua He, Jian Guo, Ai-Ping Zhou, Yang-Hong Xi, Li-Jun Ni, Yu-Feng Yao*, Wen-Juan Wu*, Streptococcus agalactiae Inhibits Candida albicans Hyphal Development and Diminishes Host Vaginal Mucosal TH17 Response, Frontier in Microbiology, 2018, 9:198.

13.Jingjing Wu#, Wenzheng Guo#, Donghua Wen#, Guangyue Hou, Aiping Zhou, Wenjuan Wu, Deubiquitination and stabilization of programmed cell death ligand 1 by ubiquitin-specific peptidase 9, X-linked in oral squamous cell carcinoma., Cancer Medicine, 2018.8, 7(8): 4004-4011.

14.Baoshan Wan#, Qiufen Zhang#, Jinjing Ni, Shuxian Li, Donghua Wen, Jun Li, Haihan Xiao, Ping He, Hongyu Ou, Jing Tao, Qihui Teng, Jie Lu, Wenjuan Wu*, Yufeng Yao*, Type VI secretion systemcontributes to Enterohemorrhagic Escherichia coli virulence by secretingcatalase against host reactive oxygen species (ROS), PLoS Pathog, 2017.3.13, 3(3): 1-28.

15.Xueen Fang, Hongmei Cao, Wenjuan Wu*, Jilie Kong*, A novel bio-microcircuit for bio-assays., RSC Advances, 2016.12, 6(79): 75875-75879.