1. 中药有效成分抗肿瘤机制研究

Study on the Anti-Tumor Mechanisms of Active Components in Traditional Chinese Medicine

2. 肿瘤围术期中西医结合及营养干预临床及机制研究

Clinical and Mechanistic Study on Integrative Medicine and Nutritional Interventions During the Perioperative Period of Cancer

3. 纳米递送系统抗肿瘤转移研究

Research on Nano-Delivery Systems for Inhibiting Tumor Metastasis

同济大学附属普陀人民医院副院长、教授、主任医师

Vice President, Professor, Chief Physician, Putuo People’s Hospital Affiliated to Tongji University

国家中医药管理局重点学科——中西医结合临床（肿瘤方向）负责人

Head of the Key Discipline of the State Administration of Traditional Chinese Medicine — Clinical Integrative Medicine (Oncology)

上海市卫生健康系统重点学科——普外科负责人

Head of the Key Discipline of the Shanghai Health System — General Surgery

上海市中西医结合学会常务理事

Executive Director, Shanghai Association of Integrative Medicine

上海市中西医结合学会全科专委会主任委员

Chairman, General Practice Committee, Shanghai Association of Integrative Medicine

上海市抗癌协会肿瘤营养专委会副主任委员

Vice Chairman, Tumor Nutrition Committee, Shanghai Anti-Cancer Association

上海市抗癌协会肿瘤筛查与预防专委会副主任委员

Vice Chairman, Tumor Screening and Prevention Committee, Shanghai Anti-Cancer Association

上海中医药科技奖一等奖

First Prize, Shanghai Traditional Chinese Medicine Science and Technology Award

上海市中西医结合科技奖三等奖

Third Prize, Shanghai Association of Integrative Medicine Science and Technology Award

上海医学科技奖三等奖

Third Prize, Shanghai Medical Science and Technology Award

上海中医药科技奖著作奖 Monograph Award, Shanghai Traditional Chinese Medicine Science and Technology Award

【代表性论文】

Xu K, Zhan Y, Yuan Z, Qiu Y, Wang H, Fan G, Wang J, Li W, Cao Y, Shen X, Zhang J, Liang X, Yin P*. Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop. Mol Ther. 2019 27(10):1810-1824. (IF:12)

Chen J, Wang H, Jia L, He J, Li Y, Liu H, Wu R, Qiu Y, Zhan Y, Yuan Z, Cao Y, Li W, Xu K, Yin P*. Bufalin targets the SRC-3/MIF pathway in chemoresistant cells to regulate M2 macrophage polarization in colorectal cancer. Cancer Lett. 2021 513:63-74. (IF:10.1)

Yuan Z, Fan G, Wu H, Liu C, Zhan Y, Qiu Y, Shou C, Gao F, Zhang J, Yin P*, Xu K. Photodynamic therapy synergizes with PD-L1 checkpoint blockade for immunotherapy of CRC by multifunctional nanoparticles. Mol Ther. 2021 29(10):2931-2948. (IF:12)

Yang J, Wang J, Liu Y, Zhang Y, Huang W, Zou Y, Qiu Y, Cai W, Gao J, Zhou H, Wu Y, Liu W, Ding Q, Zhang Y, Yin PH*, Tan W. PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation. Cell Death Dis. 2021 12(7):707. (IF:9.6)

Li Y, Chen J, Xia Q, Shang J, He Y, Li Z, Chen Y, Gao F, Yu X, Yuan Z, Yin P*. Photothermal Fe3O4 nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy. J Nanobiotechnology. 2024 22(1):630. (IF:12.6)