非小细胞肺癌免疫治疗临床试验，以及治疗过程中肿瘤微环境变化的功能与机制研究，人工气管构建与功能验证。

Clinical trials, function and mechanism of micro-environment change in non-small cell lung cancer during immunotherapy; and construction and functional validation of artificial trachea.

【科研项目】

1. CHI3L1抑制慢性干扰素刺激介导的T细胞耗竭并增强NSCLC抗PD-1免疫治疗疗效的功能与机制研究。国家自然科学基金青年项目。

2. 依沃西单抗联合化疗新辅助治疗潜在可切除局部晚期 NSCLC：一项单臂、开放标签的Ⅱ期临床研究。上海市卫生健康委员会临床研究专项青年项目。

【代表性论文】

1. Safety and effectiveness of neoadjuvant PD-1 inhibitor (toripalimab) plus chemotherapy in stage II-III NSCLC (LungMate 002): an open-label, single-arm, phase 2 trial. BMC medicine. 2022 Dec 30;20(1):493.

2. Bevacizumab-Laden Nanofibers Simulating an Antiangiogenic Niche to Improve the Submuscular Stability of Stem Cell Engineered Cartilage. Small. 2022 Jun;18(23):e2201874.

3. Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma. Nat Commun. 2021 Nov 10;12(1):6479.

4. Biomimetic Trachea Engineering via a Modular Ring Strategy Based on Bone-Marrow Stem Cells and Atelocollagen for Use in Extensive Tracheal Reconstruction. Adv Mater. 2022 Feb;34(6):e2106755.

5. MAZ promotes tumor proliferation and immune evasion in lung adenocarcinoma. Oncogene. 2024 Dec;43(50):3619-3632.

6. Immuno-Isolation Strategy with Tacrolimus-Loaded Nanofilm Promotes Stable Stem Cell-Based Cartilage Regeneration. Adv. Funct. Mater. 2025, 35, 2414567.

7. A Strategy for Diabetic Wound Healing: Electrostatic Adsorption of Structural Stability Drugs with Antibacterial, Anti-inflammatory, and Angiogenic Effects. Adv. Funct. Mater. (2025): e25109.

【Scientific research project】

1. Functional and Mechanistic Study of CHI3L1 in Inhibiting Chronic Interferon-Stimulation-Induced T Cell Exhaustion and Enhancing the Efficacy of Anti-PD-1 Immunotherapy in NSCLC. The Natural Science Foundation of China project (Youth Project C).

2. Neoadjuvant Ivoxidan anti chemotherapy for potential resectable locally advanced NSCLC, a single arm, open label phase II clinical trail. Clinical Research Project of Shanghai health commission (Youth Project ).

【Representative papers】

1. Safety and effectiveness of neoadjuvant PD-1 inhibitor (toripalimab) plus chemotherapy in stage II-III NSCLC (LungMate 002): an open-label, single-arm, phase 2 trial. BMC medicine. 2022 Dec 30;20(1):493.

2. Bevacizumab-Laden Nanofibers Simulating an Antiangiogenic Niche to Improve the Submuscular Stability of Stem Cell Engineered Cartilage. Small. 2022 Jun;18(23):e2201874.

3. Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma. Nat Commun. 2021 Nov 10;12(1):6479.

4. Biomimetic Trachea Engineering via a Modular Ring Strategy Based on Bone-Marrow Stem Cells and Atelocollagen for Use in Extensive Tracheal Reconstruction. Adv Mater. 2022 Feb;34(6):e2106755.

5. MAZ promotes tumor proliferation and immune evasion in lung adenocarcinoma. Oncogene. 2024 Dec;43(50):3619-3632.

6. Immuno-Isolation Strategy with Tacrolimus-Loaded Nanofilm Promotes Stable Stem Cell-Based Cartilage Regeneration. Adv. Funct. Mater. 2025, 35, 2414567.

7. A Strategy for Diabetic Wound Healing: Electrostatic Adsorption of Structural Stability Drugs with Antibacterial, Anti-inflammatory, and Angiogenic Effects. Adv. Funct. Mater. (2025): e25109.