围绕脊柱脊髓损伤，已主持国家自然科学基金面上项目1项，上海市卫生健康委员会青年项目1项、同济医院院级项目5项（国自然培育项目、优秀人才计划项目、专利转化孵育项目、普陀区东部医联体科研项目、临床研究培育青年项目），参加国家重点研发计划、国家自然科学基金国际合作重点项目、国家自然科学基金重点项目等国家级及省部级项目10余项；发表论文20余篇，其中以第一作者发表Signal Transduction and Targeted Therapy、VIEW、BMC Surgery等SCI论文6篇；获批发明专利3项，实用新型专利1项；先后于中华医学会第二十二届骨科学术会议暨第十五届 COA 学术大会、第14及15届国际神经修复年会、第十九届亚太微创脊柱外科年会/全国微创脊柱外科高峰论坛等会议发言。获上海市科技进步奖一等奖、第15届国际神经修复年会（IANR）“青年科学家论坛奖”（Young Scientist Forum Award）、“上海市优秀住院医师”等奖励荣誉；
Regarding spinal cord injury, I have led one National Natural Science Foundation general project, one Shanghai Health Commission youth project, and five Tongji Hospital level projects (National Natural Science Cultivation Project, Excellent Talent Plan Project, Patent Transformation Incubation Project, Putuo District Eastern Medical Consortium Research Project, Clinical Research Cultivation Youth Project), and participated in more than 10 national and provincial level projects such as National Key Research and Development Program, National Natural Science Foundation International Cooperation Key Project, and National Natural Science Foundation Key Project; Published over 20 papers, including 6 SCI papers as first author on Signal Transduction and Targeted Therapy, VIEW, BMC Surgery, etc; Obtained 3 invention patents and 1 utility model patent; He has delivered speeches at various conferences including the 22nd Orthopedic Academic Conference and the 15th COA Academic Conference of the Chinese Medical Association, the 14th and 15th International Neurorepair Annual Conferences, the 19th Asia Pacific Minimally Invasive Spinal Surgery Annual Conference/National Minimally Invasive Spinal Surgery Summit Forum, etc. Received the first prize of Shanghai Science and Technology Progress Award, the Young Scientist Forum Award at the 15th International Neuro Repair Annual Conference (IANR), and honors such as "Outstanding Resident Physician in Shanghai"
【主持或参加科研项目（课题）情况】
1)国家自然科学基金面上项目，82371380，高表达Lgals3脊髓源性NSCs亚群修复脊髓损伤的作用及机制研究，2024.01-2027.12，49万元，在研，主持
2)国家自然科学基金委员会, 重点项目, 82330062, 感觉运动区块化功能类器官修复脊髓损伤研究, 2024-01至2028-12, 220万元, 在研, 参与
3)同济大学附属同济医院临床研究青年项目，ITJ(QN)2208，基于多模态数据建立椎体成形术治疗椎体压缩性骨折术中骨水泥椎管内渗漏的预测模型，2023.1-2024.12,10万元，在研主持
4)同济大学附属同济医院普陀区东部医联体科研项目，YLT2102，OVCF椎体成形术后再骨折的危险因素分析，2022.01-2022.12，2.5万元，在研，主持
5)同济大学附属同济医院专利转化孵育项目，一种术中辅助穿刺的体表定位装置，3万元，2022.01-2022.12，3万元，在研，主持
6)国家自然科学基金委员会，面上项目，82071370，C/EBPβ-AEP-Tau N368通路介导脊髓损伤后运动神经元凋亡机制研究，2021-01至2024-12，55万，在研，参加
7)同济大学附属同济医院，优秀学科后备人才计划项目，HBRC2003，MALAT1/miR-320调控小胶质细胞命运修复脊髓损伤的作用及机制研究，2021-01至2023-12,15万元，在研，主持
8)上海市卫生与计划生育委员会, 青年项目, 20174Y0091, 雷帕霉素调控细胞自噬保护脊髓损伤后髓鞘功能的机制研究, 2018-01至2020-12, 5万元, 已结题, 主持
【学术论文】
(1)Xiao Hu#, Wei Xu#, Yilong Ren#, Zhaojie Wang#, Xiaolie He#, Runzhi Huang, Bei Ma, Jingwei Zhao, Rongrong Zhu*, Liming Cheng*. Spinal cord injury: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther. 2023 Jun 26;8(1):245.（Q1 IF 39.3）
(2) Yadong Qian#, Xiao Hu#, Chen Li, Jingwei Zhao, Yanjing Zhu, Yan Yu, Ning Xie, Bin Ma, Zhili Zeng* , Liming Cheng*. Development of a nomogram model for prediction of new adjacent vertebral compression fractures after vertebroplasty. BMC Surg. 2023 Jul 10;23(1):197（Q3 IF 1.9）
(3)Wu Z#, Zhu R#, Yu Y, Wang J, Hu X, Xu W, Ren Y, Li C, Zeng Z, Ma B, Xie N, Lin G, Ma B, Zhu R, Ye K, Cheng L*. Spinal cord injury-activated C/EBPβ-AEP axis mediates cognitive impairment through APP C586/Tau N368 fragments spreading. Prog Neurobiol. 2023 Aug;227:102467.
(4)Xiao Hu#, Yanjing Zhu#, Yadong Qian, Ruiqi Huang, Shuai Yin, Zhili Zeng, Ning Xie, BinMa, Yan Yu, Qing Zhao, ZhouruiWu, JianjieWang, Wei Xu, Yilong Ren, Chen Li, Rongrong Zhu*, Liming Cheng*. Prediction of subsequent osteoporotic vertebral compression fracture on CT radiography via deep learning.VIEW, 2022,2022012. : DOI:10.1002/VIW.20220012. （IF 8.6）
(5) Li C#, Wu Z#, Zhou L#, Shao J, Hu X, Xu W, Ren Y, Zhu X, Ge W, Zhang K, Liu J, Huang R, Yu J, Luo D, Yang X, Zhu W, Zhu R, Zheng C, Sun YE*, Cheng L*. Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury. Signal Transduct Target Ther. 2022 Mar 2;7(1):65
(6) Zhao Ziru#, Hu Xiao#, Wu Zhourui#, Chen Qi, Shao Qihui*. A Selective P2Y Purinergic Receptor Agonist 2-MesADP Enhances Locomotor Recovery after Acute Spinal Cord Injury. Eur Neurol. 2020;83(2):195-212.（Q3 IF 2.4）
(7) Zhu Rongrong#*; Hu Xiao#; Xu Wei#; Wu Zhourui; Zhu Yanjing; Ren Yilong; Cheng Liming*, LncRNA MALAT1 inhibits hypoxia/reoxygenation-induced human umbilical vein endothelial cell injury via targeting the microRNA-320a/RAC1 axis, Biological Chemistry, 2020, 401(3):349-60.（Q3 IF 3.7）
(8) Xu Wei#; Hu Xiao#; Qi Xi; Zhu Rui; Li Chen; Zhu Yanjing; Yin Shuai; Cheng Liming* ; Zhu Rongrong*; Vitamin D ameliorates angiotensin II-induced human endothelial progenitor cell injury via the PPAR-γ/HO-1 pathway, Journal of Vascular Research, 2019, 56(1):17-27.（Q4 IF 1.7）
(9) Luo Dandan; Ge Weihong*; Hu Xiao; Li Chen; Lee Chia-Ming; Zhou Liqiang; Wu Zhourui; Yu Juehua; Lin Sheng; Yu Jing; Xu Wei; Chen Lei; Zhang Chong; Jiang Kun; Zhu Xingfei; Li Haotian; Gao Xinpei; Geng Yanan; Jing Bo; Wang Zhen; Zheng Changhong; Zhu Rongrong; Yan Qiao; Lin Quan; Ye Keqiang; Sun Eve Yi*; Cheng Liming*; Unbiased transcriptomic analyses reveal distinct effects of immune deficiency in CNS function with and without injury, Protein & Cell, 2019, 10(8):566-82.
(10) Gao Shane; Guo Xuanxuan; Zhao Simeng; Jin Yinpeng; Zhou Fei; Yuan Ping; Cao Limei; Wang Jian; Qiu Yue; Sun Chenxi; Kang Zhanrong; Gao Fengjuan; Xu Wei; Hu Xiao; Yang Danjing; Qin Ying; Ning Ke; Shaw Pamela J; Zhong Guisheng*; Cheng Liming*; Zhu Hongwen*; Gao Zhengliang*; Chen Xu*; Xu Jun*; Differentiation of human adipose-derived stem cells into neuron/ motoneuron -like cells for cell replacement therapy of spinal cord injury, Cell Death & Disease, 2019, 10(8):597.
(11) 胡笑，谢宁*，程黎明。胸椎骨折经皮椎体成形术后合并血胸一例。中华创伤杂志，2020；36（5）;478-480.
(12) 胡笑，曾至立*，贾永伟，徐委，王建杰，占新华，赵经纬，程黎明。下腰椎爆裂性骨折不同手术方案的选择。外科研究与新技术，2017, 6(2)：73-77.
(13) 胡笑，曾至立，程黎明*。下腰椎骨折的诊疗进展，中国矫形外科杂志。2017；25(2):141-143.
