上海市中西医结合学会关节病专业委员会委员Members of the Association of Integrative Chinese and Western Medicine, Shanghai joint disease Professional Committee
1、主持课题
(1)国家自然科学基金青年项目,81802141,低氧/HIF-α通路在骨细胞参与磨损颗粒诱导假体周围骨溶解中的作用和机制研究,2019/01-2021/12,21万元,主持,在研。
(2)上海市科委青年科技英才扬帆计划项目, 18YF1419200,低氧/HIF-α通路调控骨细胞生物学行为在超高分子量聚乙烯颗粒诱导假体周围骨溶解中的作用及机制研究,2018/05-2021/04,20万元,主持,已结题。2、代表性论著
(1)Kang, Hui#; Yang, Kai#; Xiao, Lianbo#; Guo, Lei; Guo, Changjun; Yan, Yufei; Qi, Jin; Wang, Fei; Ryffel, Bernhard; Li, Changwei*; Deng, Lianfu*, Osteoblast hypoxia-inducible Factor-1 alpha Pathway activation restrains Osteoclastogenesis via the interleukin-33-MicroRNA34a-notch1 Pathway , FRONTIERS IN IMMUNOLOGY, 2017.10.16, 8: 1312 (期刊论文)
(2)Kang, Hui#; Yan, Yufei#; Jia, Peng#; Yang, Kai; Guo, Changjun; Chen, Hao; Qi, Jin; Qian, Niandong; Xu, Xing; Wang, Fei; Li, Changwei*; Guo, Lei*; Deng, Lianfu*, Desferrioxamine reducesultrahigh-molecular-weight polyethylene-induced osteolysis by restraining inflammatory osteoclastogenesis via heme oxygenase-1 , CELL DEATH & DISEASE, 2016.10.27,7(10):e2435 (期刊论文)
(3) Kang, H. #; Chen, H.#; Huang, P.; Qi, J.; Qian, N.; Deng, L.*; Guo, L.*, Glucocorticoids impair bone formation of bone marrow stromal stem cells by reciprocally regulating microRNA-34a-5p , OSTEOPOROSIS INTERNATIONAL, 2016.4, 27(4): 1493~1505 (期刊论文)
(4)Chen, Hao#; Jia, Peng#; Kang, Hui#; Zhang, Hongbo#; Liu, Yi; Yang, Peilang; Yan, Yufei; Zuo, Guilai; Guo, Lei; Jiang, Min; Qi, Jin; Liu, Yuanyuan*; Cui, Wenguo*; Santos, Helder A.*; Deng, Lianfu*, Upregulating Hif-1 by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound , ADVANCED HEALTHCARE MATERIALS,2016.4.20, 5(8): 907~918 (期刊论文)
(5) Li C.#; Chen K.#; Kang H.#; Yan Y.; Liu K.; Guo C.; Qi J.; Yang K.; Wang F.; Guo L.*; He C.*; Deng L.*,Double-stranded RNA released from damaged articular chondrocytes promotes cartilage degeneration via Toll-like receptor 3-interleukin-33 pathway, Cell Death Dis, 2017.11.2, 8(11): e3165 (期刊论文)