颅脑及脊髓肿瘤、颅脑创伤的诊疗研究Diagnosis and treatment of cerebrospinal tumor and traumatic brain injury

上海市第十人民医院崇明分院神经外科执行主任，博士生导师Executive Director of Neurosurgery, Chongming Branch of Shanghai Tenth People

发表论文60余篇，参加课题6项，获得实用性专利1项Published more than 60 papers, participated in 6 research topics, obtained practical patents 1

近三年论著：Articles in the past three years:[1] Fu J Q , Chen Z , Hu Y J , et al. A single factor induces neuronal differentiation to suppress glioma cell growth[J]. CNS Neuroscience & Therapeutics, 2018.

[2] Xu X, Zhang F, Chen X, et al. MicroRNA-518b functions as a tumor suppressorin glioblastoma by targeting PDGFRB:[J]. Molecular Medicine Reports, 2017, 16(4):5326-5332.

[3] Chen Z, Fu J, Fei X, Chen XZ, et al. Knockdown of ribosomal protein S15A induces human glioblastoma cell apoptosis[J]. World Journal of Surgical Oncology,2016, 14(1):1-7.

[4] Xue F, Shen R, Chen X. Analysis of gene profiles in glioma cells identifies potential genes, miRNAs, and target sites of migratory cells.[J]. Tumori, 2015, 101(5):542.

[5] Tang X, Chen XZ, Xu Y, et al. CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells.[J]. Cellular Signalling, 2015,27(9):1694-1702.

[6] Shi X, Chen XZ, Peng H, et al. Lentivirus-mediated silencing of spindle and kinetochore-associated protein 1 inhibits the proliferation and invasion of neuronal glioblastoma cells.[J]. Molecular Medicine Reports, 2015, 11(5):3533.

获得专利：Patents:[1] 钟荣德,陈先震,高亮,万志刚,张欣. 神经外科颅骨缺损修补用钛网结构.专利号：2016211582890. 授权日期：2017-08-22.