【近年来主持科研项目及人才计划项目情况】
1、2023年国家重点研发计划项目课题：先天性结构畸形早期智能诊断平台与指南标准构建及临床应用（2023YFC2705705）负责人，330万。
2、2018年国家自然科学基金项目：胸腺和胸腺外来源的调节性T细胞在妊娠耐受中的作用（81871217），57万元。
3、2015年国家自然科学基金项目：自然杀伤细胞在子痫前期发生中的作用及其机制研究（81571510），72万元。
4、2013年国家自然科学基金项目：Th17细胞和调节性T细胞失衡在iNKT细胞介导的流产中的作用（81370769），70万元。
5、2012年国家自然科学基金项目：iNKT细胞在炎症性早产中作用的研究（81200478），23万元。
6、2019年广州市科技计划项目：胸腺和胸腺外来源的调节性T细胞在妊娠耐受中的作用（201904010390），20万元。
7、2022年深圳市科创委面上项目（JCYJ20220530151809021）：CD71+红系细胞和髓外红系造血在妊娠耐受中的作用，15万元。
8、2014年广州市科技计划项目：母-胎界面iNKT细胞在流产中的作用及其机制探讨（2014Y00202）：20万元。
【发表文章】
1. Mei X, Li Y, Zhang X, Zhai X, Yang Y, Li Z, Li L (通讯). Maternal phlorizin intake protects offspring from maternal obesity-induced metabolic disorders in mice via targeting gut microbiota to activate the SCFA-GPR43 pathway. J Agric Food Chem. 2024; 72(9): 4703-4725.
2. Fu Y, Li Z, Lin W, Yao J, Jiang X, Shu Q, Mao X, Tu J, Liang X, Li L (通讯). Extramedullary hematopoiesis contributes to enhanced erythropoiesis during pregnancy via TGF-β signaling. Front Immunol. 2023; 14: 1295717. 2q 7.3
3. Li Z, Liang X, Chen X, Chen Y, Wang F, Wang S, Liao Y, Li L (通讯). The role of thymus- and extrathymus-derived regulatory T cells in maternal-fetal tolerance. Front Immunol. 2023; 14: 1109352.
4. Li L (通讯), Tu J, Jiang Y, Zhou J, Schust DJ (通讯). Regulatory T cells decrease invariant natural killer T cell-mediated pregnancy loss in mice. Mucosal Immunol. 2017; 10(3): 613-623.
5. Li Z, Wang S, Li L (通讯). Advanced oxidative protein products (AOPPs) drive trophoblast cells into senescence by inhibiting the autophagy: the potential implication of preeclampsia. Front Cell Dev Biol. 2022; 10: 810282.
6. Liang X, Wang R, Luo H, Liao Y, Chen X, Xiao X, Li L (通讯). The interplay between the gut microbiota and metabolism during the third trimester of pregnancy. Front Microbiol. 2022; 13: 1059227.
7. Wei Z, Hu Y, He X, Ling W, Yao J, Li Z, Wang Q, Li L (通讯). Biomaterializing the advances in uterine tissue engineering. iScience. 2022; 25(12):105657.
8. Wei Z, Zhang M, Zhang X, Fang X, Li L (通讯). Knockdown has_circ_0063526 inhibits endometriosis progression via regulating the miR-141-5p/EMT axis and downregulating estrogen receptors. Aging-US Aging (Albany NY). 2021; 13(24):26095-26117.
9. Li L, Fang Y, Dong G, Lin Y (通讯), Saito S (通讯). Depletion of iNKT cells reduces inflammation-induced preterm delivery in mice. J Immunol. 2012; 188(9): 4681-4689.
10. Li L (通讯), Zhou J, Wang W, Huang L, Tu J, Baiamonte L, et al. Effects of three long-acting reversible contraceptive methods on HIV target cells in the human uterine cervix and peripheral blood. Reprod Biol Endocrinol. 2019; 17(1):26.
11. Li L (通讯), Tu J, Jiang Y, Zhou J, Yabe S, Schust DJ (通讯). Effects of lipopolysaccharide on human first trimester villous cytotrophoblast cell function in vitro. Biol Reprod. 2016; 94(2): 33.
12. Li L, Yang J, Jiang Y, Tu J, Schust DJ (通讯). Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth. Mol Hum Reprod. 2015; 21(4): 369-381.
13. Li L (通讯), Kang J, Lei W. Role of Toll-like receptor 4 in inflammation-induced preterm delivery. Mol Hum Reprod. 2010; 16(4): 267-272.
14. Liu Lu, Huang XX, Xu CF, Chen CQ, Zhao WJ, Li DJ, Li LP (通讯), Wang Li (通讯), Du MR (通讯). Decidual CD8+ T cells exhibit both residency and tolerance signatures modulated by decidual stromal cells. J Transl Med. 2020; 18(1): 221.
15. Du M, Wang W, Huang L, Guan X, Lin W, Yao J, Li L (通讯). Natural killer cells in the pathogenesis of preeclampsia: a double-edged sword. J Matern Fetal Neonatal Med. 2022; 35(6):1028-1035.
16. Zhao W, Cui L, Huang X, Wang S, Li D, Li L (通讯), Sun Y (通讯), Du M (通讯). Activation of Rev-erbα attenuates lipopolysaccharide-induced inflammatory reactions in human endometrial stroma cells via suppressing TLR4-regulated NF-κB activation. Acta Biochim Biophys Sin. 2019; 51(9): 908-914.
17. Guan X, Huang L, Li L (通讯). Acute mesenteric venous thrombosis in a pregnant woman at 35 weeks of gestation: a case report and review of the literature. BMC Pregnancy Childbirth. 2018; 18(1):487.
18. Li L, Schust DJ (通讯). Isolation, purification and in vitro differentiation of cytotrophoblast cells from human term placenta. Reprod Biol Endocrinol. 2015; 13: 71.
19. Li L, Shi L, Yang X, Ren L, Yang J, Lin Y (通讯). Role of invariant NKT cells in lipopolysaccharide-induced pregnancy loss. Cell Immunol. 2013; 286(1-2): 1-10.
20. Li L, Yang J, Ren L, Fang Y, Lin Y (通讯). Invariant NKT cells increase lipopolysacchride-induced pregnancy loss by a mechanism involving Th1 and Th17 responses. J Matern Fetal Neonatal Med. 2013; 26(12): 1212-1218.
21. Li L, Yabe S, Schust DJ (通讯). Involvement of decidual invariant NKT cells in inflammation-induced preterm delivery. Inflamm Cell Signal. 2015; 2: e843.
