妊娠期相关疾病的发病机制及预测、预防和诊治；出生缺陷的产前诊断、染色体异常的产前筛查、染色体异常和单基因遗传性疾病的诊断；成人疾病的胎儿起源；胎盘源性疾病的发病机制研究

Pathogenesis, prediction, prevention, diagnosis, and treatment of pregnancy-related disorders; prenatal diagnosis of birth defects, prenatal screening for chromosomal abnormalities, and diagnosis of chromosomal anomalies and monogenic genetic diseases; Developmental Origins of Health and Disease (DOHaD); and research on the pathogenesis of placenta-associated disorders.

同济大学教授、主任医师、博士研究生导师。曾任同济大学附属妇产科医院（上海市第一妇婴保健院）院长，上海市妇幼保健所所长，现任同济大学附属东方医院妇产科主任、妇儿生殖医学部主任、医学人工智能创新中心主任、国际医院负责人，世界围产学会理事，国际围产医学科学院Fellow， WHO世界卫生组织产科专家委员,FIGO（国际妇产科联盟）专家委员会成员,亚太母胎医学专家联盟主席。中华围产学会名誉主任委员,上海市胎儿医学学会理事，中国DOHaD联盟创始人兼共同主席。

Professor, Chief Physician, and Doctoral Supervisor at Tongji University. Formerly served as President of Tongji University Affiliated Obstetrics and Gynecology Hospital (Shanghai First Maternity and Infant Hospital) and Director of Shanghai Municipal Maternal and Child Health Institute. Currently holds the positions of Director of the Department of Obstetrics and Gynecology at Tongji University Affiliated East Hospital, Director of the Maternal, Child and Reproductive Medicine Department, Director of the Medical Artificial Intelligence Innovation Center, and Head of International Hospital. Also serves as Council Member of the World Association of Perinatal Medicine, Fellow of the International Academy of Perinatal Medicine, Member of the Obstetrics Expert Committee of the World Health Organization (WHO), Member of the Expert Committee of the International Federation of Gynecology and Obstetrics (FIGO), and Chair of the Asia-Pacific Alliance of Maternal-Fetal Medicine Experts. Holds honorary titles including Honorary Chair of the Chinese Perinatal Society, Council Member of the Shanghai Fetal Medicine Association, and Founder and Co-Chair of the Chinese DOHaD Alliance.

长期从事围产医学相关的临床及科研工作，担任“The Journal of Maternal-Fetal & Neonatal Medicine” “Prenatal Diagnosis” “British Journal of Obstetrics and Gynecology”等杂志编委。承担了多项国家级和市级重点科研项目，先后主持7项NSFC面上项目,发表SCI文章72篇，主编/主译专著20余部，其中包括第10版《妇产科学》、《Williams产科学》、《Novak妇科学》及《TeLinde妇科手术学》等。先后承担科技部重点研发计划首席科学家、上海市优秀学科带头人、上海市医学领军人才、国家临床重点专科（产科）等多个科研或人才项目。

With long-term dedication to clinical practice and scientific research in perinatal medicine, he serves as an editorial board member for several prestigious journals, including The Journal of Maternal-Fetal & Neonatal Medicine, Prenatal Diagnosis, and BJOG: An International Journal of Obstetrics and Gynaecology. He has undertaken numerous national and municipal key research projects, having served as principal investigator for 7 NSFC General Programs. His/her academic output includes 72 SCI-indexed publications and over 20 monographs authored, edited, or translated, notably the 10th edition of Obstetrics and Gynecology, Williams Obstetrics, Novak's Gynecology, and Te Linde's Operative Gynecology. He has also led or participated in several major research and talent programs, serving as Chief Scientist for a National Key R&D Program, and holding titles such as Shanghai Outstanding Academic Leader, Shanghai Medical Leading Talent, and heading the National Clinical Key Specialty (Obstetrics).

发表文章 Publications

1. Meng L (#), Meng M (#), Zhang R, Wubulikasimu A, Peng H, Zhang L, Chang X, Ai G, Zou G, He Q, Wang K (*), Liu M (*), Duan T (*). Microbiome-producing SCFAs are associated with preterm birth via trophoblast function modulation. mBio. 2024; 15(12), e0270224. (期刊论文)

2. Ru P, Ni X, Xu W, Liu Y, Meng L, Yuan W, Gu Z, Shi J, Su X, Liu M(*), Duan T(*). Perinatal outcomes in patients undergoing repeat cerclage: A retrospective case series study. Int J Gynaecol Obstet. 2024 Apr;165(1):343-349. (期刊论文).

3. Xu W, Ni X, Liu Y, Meng L, Ru P, Gu Z, Yan Y, Yuan W, Su X, Liu M(*), Duan T(*). Transvaginal cerclage for prevention of preterm birth in twin pregnancies with cervical dilatation or shortening: A prospective observational study. Int J Gynaecol Obstet. 2024 Mar;164(3):942-950. (期刊论文).

4. Chang X (#), He Q (#), Wei M, Jia L, Wei Y, Bian Y, Duan T (*), Wang K (*). Human umbilical cord mesenchymal stem cell derived exosomes (HUCMSC-exos) recovery soluble fms-like tyrosine kinase-1 (sFlt-1)-induced endothelial dysfunction in preeclampsia. European journal of medical research, 2023, 28(1), 277 (期刊论文).

5. Guo L (#), Liu M, Duan T (*). Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia. Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2023, 32(3), 357–367 (期刊论文).

6. Zhang R (#), Jia L (#), Meng L, Peng H, Zhang D, He Q, Duan T (*), Wang K (*). PD-L1 enhances migration and invasion of trophoblasts by upregulating ARHGDIB via transcription factor PU.1. Cell death discovery, 2022, 8(1), 395 (期刊论文).

7. Zhao X, Frempong ST, Duan T*. Uric acid levels in gestational hypertensive women predict preeclampsia and outcome of small-for-gestational-age infants. J Matern Fetal Neonatal Med. 2021 Sep;34(17):2825-2831. (期刊论文)

8. Su X, Liu Y, Li G, Liu X, Huang S, Duan T(*), Du Q(*). Associations of Hypothyroxinemia With Risk of Preeclampsia-Eclampsia and Gestational Hypertension. Front Endocrinol (Lausanne). 2021 Nov 4;12:777152. (期刊论文)

9. Xinwen Chang(#); Julei Yao(#); Qizhi He; Ming Liu; ; Kai Wang(*); Tao Duan(*), Exosomes From Women With Preeclampsia Induced Vascular Dysfunction by Delivering sFlt (Soluble Fms-Like Tyrosine Kinase)-1 and sEng (Soluble Endoglin) to Endothelial Cells, HYPERTENSION, 2018.12.30, 72(6): 1381~1390 (期刊论文)；

10. Xinwen Chang(#); Hua Li(#); Yuhong Li; Qizhi He; Julei Yao; Tao Duan(*); Kai Wang(*), RhoA/MLC Signaling Pathway is Involved in Delta(9)-tetrahydrocannabinol-impaired Placental Angiogenesis, TOXICOLOGY LETTERS, 2018.4, 285: 148~155 (期刊论文)；

11. Hua Li(#); Julei Yao; Xinwen Chang; Jingting Wu; Kai Wang(*), Tao Duan(*), LIFR Increases the Release of Soluble Endoglin via the Upregulation of MMP14 Expression in Preeclampsia, REPRODUCTION, 2018.03, 155(3): 297~306 (期刊论文)；

12. Luming Sun(#); Gang Zou; Yingjun Yang; Fenhe Zhou; Tao Duan(*), Risk Factors For Fetal Death After Radiofrequency Ablation For Complicated Monochorionic Twin Pregnancies, PRENATAL DIAGNOSIS, 2018.3.12, 38(无): 499~503 (期刊论文)；

13. Julei Yao(#); Qizhi He(#); Ming Liu; Xinwen Chang; Jinting Wu; Tao Duan(*); Kai Wang(*), Effects of Delta(9)-tetrahydrocannabinol (THC) on Human Amniotic Epithelial Cell Proliferation and Migration, TOXICOLOGY, 2018.02, 394: 19~26 (期刊论文)；

14. Zou G(#), Liu T(*), Guo LH, Huang YY, Feng Y, Duan T(*). MicroRNA-32 silences WWP2 expression to maintain the pluripotency of human amniotic epithelial stem cells and islet-like cell differentiation, International Journal of Molecular Medicine, 2018, 41(4):1983~1991 (期刊论文)；

15. Jingping Zhu(#); Kai Wang; Ting Li; Jiayu Chen; Dandan Xie; Xinwen Chang; Julei Yao; Jinting Wu; Qian Zhou; Yuanhui Jia(*); Tao Duan(*), Hypoxia-induced TET1 Facilitates Trophoblast Cell Migration and Invasion Through HIF1 alpha Signaling Pathway, SCIENTIFIC REPORTS, 2017.08, 7(1): 1~11 (期刊论文)；

16. Xinwen Chang(#); Yiding Bian(#); Qizhi He; Julei Yao; Jinping Zhu; Jinting Wu; Kai Wang(*); Tao Duan(*), Suppression of STAT3 Signaling by Delta(9)-Tetrahydrocannabinol (THC) Induces Trophoblast Dysfunction, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017.06, 42(2): 537~550 (期刊论文)；

17. Chi FL(#), Li KM, Sun J, Duan T(*). Term Delivery in a Woman with Severe Uterine Dehiscence After a Previous Cesarean Section, Journal of Reproductive Medicine, 2017.03.04, 62:200~203 (期刊论文)；

18. Yuanhui Jia(#); Ting Li(#); Xiaojie Huang; Xianghong Xu; Xinyao Zhou; Linyan Jia; Jingping Zhu; Dandan Xie; Kai Wang; Qian Zhou; Liping Jin; Jiqin Zhang(*); Tao Duan(*), Dysregulated DNA Methyltransferase 3A Upregulates IGFBP5 to Suppress Trophoblast Cell Migration and Invasion in Preeclampsia. , Hypertension, 2017.2.01, 69(2): 356~366 (期刊论文)；

19. Xinli Xiang(#); Depeng Zhao(#); Chonglan Gao; Kai Wang; Qian Zhou; Jiuhong Kang; Tao Duan(*), Maternal Administration of Magnesium Sulfate Promotes Cell Proliferation in Hippocampus Dentate Gyrus in Offspring Mice After Exposing to Prenatal Stress, International Journal of Developmental Neuroscience, 2017.2, 56: 52~57 (期刊论文)；

20. Gang Zou(#); Te Liu; Lihe Guo; Yongyi huang; Ya Feng; Qin Huang; Tao Duan(*), miR-145 Modulates IncRNA-ROR and Sox2 Expression to Maintain Human Amniotic Epithelial Stem Cell Pluripotency and beta Islet-like Cell Differentiation Efficiency, GENE, 2016.10.10, 591(1): 48~57 (期刊论文)；

21. Wu JT(#), Yao JL, Wang K(*), Duan T(*). Expression of lysyl oxidase (LOX) in human placental amnion in preterm labor, International Journal of Clinical and Experimental Pathology, 2016.09.15, 9(9):9231~9236 (期刊论文)；

22. Zhou J(#), Ni XT, Huang XJ, Yao JL, He QZ, Wang K(*), Duan T(*). Potential Role of Hyperglycemia in Fetoplacental Endothelial Dysfunction in Gestational Diabetes Mellitus, Cellular Physiology and Biochemistry, 2016.09.08, 39(4):1317~1328 (期刊论文)；

23. Yanming Wu(#); Xiao Chen; Xinwen Chang; Yajing Huang; Shihua Bao; QizhivHe; Yan Li; Jing Zheng; Tao Duan(*); Kai Wang(*), Potential Involvement of Placental AhR in Unexplained Recurrent Spontaneous Abortion, REPRODUCTIVE TOXICOLOGY, 2016.1, 59: 45~52 (期刊论文)；

24. Zhou, Jian(#); Ni, Xiaotian(#); Huang, Xiaojie; Yao, Julei; He, Qizhi; Wang, Kai(*); Duan, Tao(*), Potential Role of Hyperglycemia in Fetoplacental Endothelial Dysfunction in Gestational Diabetes Mellitus. , Cellular Physiology and Biochemistry, 2016, 39(4): 1317~1328 (期刊论文)；

25. Yajing Huang(#); Yanming Wu; Xinwen Chang; Yan Li; Kai Wang(*); Tao Duan(*), Effects of Human Umbilical Cord Mesenchymal Stem Cells on Human Trophoblast Cell Functions In Vitro. , Stem Cells Int, 2016, 2016: 9156731~9156731 (期刊论文)；

26. Zheng Bian; Chenzi Shixia; Tao Duan, First-Trimester Maternal Serum Levels of sFLT1, PGF and ADMA Predict Preeclampsia., PLOS ONE,2015.4, 10(4):e0124684 (期刊论文)；

27. Meng Meng(#); Xuchao Li(#); Huijuan Ge(#); Fang Chen; Mingyu Han; Yanyan Zhang; Dongyang Kang; Weiwei Xie; Zhiying Gao; Xiaoyu Pan; Pu Dai; Fanglu Chi; Shengpei Chen; Ping Liu; Chunlei Zhang; Jianjun Cao; Hui Jiang; Xun Xu; Wei Wang(*); Tao Duan(*), Noninvasive Prenatal Testing For Autosomal Recessive Conditions By Maternal Plasma Sequencing In A Case Of Congenital Deafness. , Genetics in Medicine, 2014.12, 16(12): 972~976 (期刊论文)；

28. Shen ZJ(#), Wu YM(#), Chen X, Chang XW, Zhou Q, Zhou J, Ying H, Zheng J, Duan T(*), Wang K(*), Decreased Maternal Serum 2-Methoxyestradiol Levels are Associated with the Development of Preeclampsia, Cellular Physiology and Biochemistry, 2014.12.04, 34(06):2189~2199 (期刊论文)；

29.Yuyan Ai(#); Qidong Liu; Yanyi Li; Tao Duan(*), Progesterone Signaling/miR-200a/zeb2 Axis Regulates Self-renewal of Mouse Embryonic Stem Cells , Biomedicine & Pharmacotherapy, 2014.3, 68(2): 201~208 (期刊论文)