生殖医学/Reproductive medicine
生殖内分泌学/Reproductive endocrinology
卵巢刺激方案个体化应用研究/Research on the individualization of ovarian stimulation protocols

上海市中西医结合协会不孕不育专委会常务委员/Standing Committee Member of Shanghai Association of Chinese Integrative Medicine Infertility Expert Group
中国优生优育协会助孕与优生专委会委员/Commissioner of Special Committee of Assisted Reproductive and Improving Birth Outcome of Chinese Association for Improving Birth Outcome and Child Development

从事辅助生殖相关临床工作20余年，临床经验丰富，科研功底扎实，勇于在实践中探索新方法，提出了诸多革新性理念。2012年创造性的将天然孕激素用于卵巢刺激过程中，设计出世界首例基于冷冻胚胎移植的孕激素方案——“安琪坦方案”，目前孕激素方案已得到国内外同行的广泛认可及应用，2019年欧洲人类生殖与胚胎学学会（European Society of Human Reproduction and Embryology, ESHRE）将孕激素方案写入最新版的卵巢刺激指南；在此基础上，进一步研究设计出“晚卵泡期卵巢刺激方案”，该方案自晚卵泡期启动，单用Gn完成卵巢刺激，无需额外添加外源性垂体调控剂。

目前以第一作者或者通讯作者发表SCI文章13篇，主持课题4项，担任多个SCI期刊审稿人：Frontiers in endocrinology，American journal of reproductive immunology，Gynecological Endocrinology，Medicine，Scientific reports，Human fertility，Journal of Obstetrics and Gynaecology等。

主持科研课题4项：

(1)同济大学附属上海市第一妇婴保健院人才项目，2020RC02，晚卵泡期卵巢刺激方案的个体化应用研究，2020-5至2025-04，50万元。

(2)上海市科委医学引导类科技项目，18411963800，来曲唑在多囊卵巢综合征患者促排卵过程中的个体化应用研究，2018-10至2021-09，20万元。

(3)上海市科委医学引导类科技项目，17411963700，孕激素方案在多囊卵巢综合征患者控制性卵巢刺激过程中的应用与优化研究，2017-07至2020-06，20万元。

(4)上海市卫生局，2010276，FSH受体基因Asn680Ser多态性与卵巢反应性关系的研究，2011-01至2012-12，5万元。

代表性文章：

(1)Xiuxian Zhu, Jing Ye, Yonglun Fu*. Premature ovarian insufficiency patients with viable embryos derived from autologous oocytes through repeated oocyte retrievals could obtain reasonable cumulative pregnancy outcomes following frozen-embryo transfer. Ann Transl Med, 2021,9(7):539. (IF=3.932)

(2)Xiuxian Zhu, Jing Ye, Yonglun Fu*. Progesterone protocol versus gonadotropin-releasing hormone antagonist protocol in women with polycystic ovarian syndrome undergoing in vitro fertilization treatments with frozen-thawed embryo transfer: a prospective randomized controlled trial. Ann Transl Med, 2021,9(5):387.(IF=3.932)

(3) Xiuxian Zhu, Jing Ye, Yonglun Fu*. Late follicular phase ovarian stimulation without exogenous pituitary modulators, Front Endocrinol (Lausanne), 2020,11:487. (IF=5.555)

(4) Xiuxian Zhu, Yonglun Fu*. Randomized, controlled pilot study of low-dose human chorionic gonadotropin administration beginning from the early follicular phase for women with polycystic ovarian syndrome undergoing ovarian stimulation using the progesterone protocol. Front Endocrinol (Lausanne), 2019,10:875. (IF=3.644)

(5) Xiuxian Zhu, Yonglun Fu*. Evaluation of ovarian stimulation initiated from the late follicular phase using human menopausal gonadotropin alone in normal-ovulatory women for treatment of infertility: a retrospective cohort study, Front Endocrinol (Lausanne), 2019,10:448. (IF=3.644)

(6) Ningling Wang, Jiaying Lin, Qianqian Zhu , Yong Fan, Yun Wang, Yonglun Fu*, Yanping Kuang*.Comparison of neonatal outcomes and live-birth defects after progestin-primed ovarian stimulation versus conventional ovarian stimulation for in vitro fertilization: a large retrospective cohort study. Medicine (Baltimore),2018,97(34):e11906. (IF=1.87)

(7) Xiuxian Zhu, Hongjuan Ye, Yonglun Fu*. Duphaston and human menopausal gonadotropin protocol in normally ovulatory women undergoing controlled ovarian hyperstimulation during in vitro fertilization/intracytoplasmic sperm injection treatments in combination with embryo cryopreservation. Fertil Steril, 2017,108(3): 505~512. (IF=4.803)

(8) Xiuxian Zhu, Hongjuan Ye, Yonglun Fu*. Use of Utrogestan duringcontrolled ovarian hyperstimulation in normally ovulating women undergoing invitro fertilization or intracytoplasmic sperm injection treatments incombination with a "freeze all" strategy: a randomized controlled dose-finding study of 100 mg versus 200 mg. Fertil Steril, 2017, 107(2): 379~386. (IF=4.803)

(9) Xiuxian Zhu, Hongjuan Ye, Yonglun Fu*. The effect of frozen-thawed embryo transfer performed concurrently with hysteroscopy on the reproductive outcomes during assisted reproductive treatments. Sci Rep, 2017, 7(1): 11852. (IF=4.122)

(10) Xiuxian Zhu, Hongjuan Ye, Yonglun Fu*. Comparison of neonatal outcomes following progesterone use during ovarian stimulation with frozen-thawed embryo transfer. Sci Rep, 2017, 7(1): 7835. (IF=4.122)

(11) Xiuxian Zhu, Hongjuan Ye, Yonglun Fu*. The Utrogestan and hMG protocol in patients with polycystic ovarian syndrome undergoing controlled ovarian hyperstimulation during IVF/ICSI treatments. Medicine (Baltimore), 2016, 95(28): e4193. (IF=1.803)

(12) Xiuxian Zhu, Xiaole Zhang, Yonglun Fu*. Utrogestan as an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in vitro fertilization. Medicine (Baltimore), 2015, 94(21): e909. (IF=1.206)

(13) Yun Wang#, Yonglun Fu#, Songguo Xue, Ai Ai, Hong Chen, Qifeng Lyu, Yanping Kuang*. The M2 polarization of macrophage induced by fractalkine in the endometriotic milieu enhances invasiveness of endometrial stromal cells. Int J Clin Exp Pathol. 2013 Dec 15;7(1):194-203. (IF=1.783)