刘铭主任带领的产科团队在著名妇产科学家段涛教授的指导下开展临床及科研工作。作为早产专病带头人，刘铭主任创建了以宫颈长度筛查为核心的早产防治体系，并将高位宫颈环扎等技术打造为团队特色品牌。
在学科建设方面，刘铭主任牵头组建"上海市东方早产救治联盟"，联合全国200余家单位共同推动诊疗同质化；参与制定多项国家级行业指南与专家共识；并持续牵头举办全国性早产大会与系列培训，推动行业规范化发展与学术引领。团队现有卫生青年人才A类及临床研究PI各1名、在站博士后2名、博士及硕士研究生4名、科研护士2名，另有3名临床医生深度参与科研工作，实现临床与科研的有机融合，形成了衔接紧密的临床科研人才体系。
在研究方向上，团队主要从事早产与未足月胎膜早破的临床综合防治及基础机制研究，聚焦母胎免疫调控、羊膜上皮细胞功能与胎膜完整性维持的分子机制；同步推进早产专病数据库建设与孕期队列研究，持续积累高质量临床数据；开展随机对照试验（RCT），以高级别循证证据指导临床实践；并积极拓展医学人工智能领域，探索智能技术在产科诊疗、教学、科研和管理中的应用，推动学科向数智化方向发展。团队氛围融洽、支持有力，始终将学生的成长置于核心位置。除刘铭主任的悉心指导外，每位学生均配有一对一带教老师，在课题设计、临床实践、实验操作与论文撰写等各环节提供全程、密切的个性化指导。团队成员之间协作紧密、互帮互助，让每一位加入的学生都能在良好的科研氛围中快速成长、充分发展。
The obstetrics team led by Director Liu Ming conducts clinical and research work under the guidance of Professor Duan Tao, a distinguished expert in obstetrics and gynecology. As the leading specialist in preterm birth, Director Liu Ming has established a preterm prevention and management system centered on cervical length screening, and has built high-level cervical cerclage and related techniques into the team's signature clinical brand.
In terms of discipline development, Director Liu Ming spearheaded the formation of the "Shanghai Oriental Preterm Birth Rescue Alliance," uniting more than 200 institutions across the country to promote standardized diagnosis and treatment. The team has also contributed to the development of multiple national clinical guidelines and expert consensus statements, and has continuously organized national preterm birth conferences and training programs to drive the standardization and academic advancement of the field. The team comprises one Class A Municipal Young Health Talent and one Clinical Research PI, two postdoctoral researchers, four doctoral and master's students, and two research nurses. Three additional clinicians are deeply involved in research activities, bridging clinical practice and scientific inquiry to form a well-integrated talent pipeline.
The team's research focuses on the comprehensive clinical prevention and treatment of preterm birth and preterm premature rupture of membranes (PPROM), as well as the underlying biological mechanisms, with particular emphasis on maternal-fetal immune regulation, amniotic epithelial cell function, and the molecular mechanisms governing fetal membrane integrity. In parallel, the team is advancing the development of a dedicated preterm birth database and pregnancy cohort studies to continuously accumulate high-quality clinical data; conducting randomized controlled trials (RCTs) to guide clinical practice with high-level evidence; and actively expanding into medical artificial intelligence, exploring the application of intelligent technologies in obstetric care, education, research, and management — driving the discipline toward digital and intelligent transformation. The team fosters a warm and supportive environment, placing student development at the heart of everything it does. In addition to Director Liu Ming's personal mentorship, each student is paired with a dedicated one-on-one supervisor who provides close, individualized guidance throughout every stage — from research design and clinical training to laboratory work and thesis writing. With a culture of collaboration and mutual support, every student who joins the team is empowered to grow rapidly and reach their full potential.
主持或参加科研项目（课题），累计经费超 1800 万元（Research Projects Undertaken or Participated In, with total funding exceeding 18 million RMB）:
1. 同济大学 “医学 + X” 交叉研究重点项目，0Bsafe 孕产安全垂类模型构建及应用系统研究，2026.01-2028.12，100 万，在研，主持。Key Program of "Medicine + X" Interdisciplinary Research, Tongji University. Construction and Application of 0Bsafe Vertical Model for Maternal Safety. 2026.01–2028.12. 1,000,000 RMB. Ongoing. Principal Investigator.
2. 浦东新区卫健委研究者发起临床研究（队列建设），基于多中心母婴队列联合 AI 驱动早产预测模型构建与新型标志物探索，2026-PWDL-14，2026.01-2028.12，60 万，在研，主持。Researcher-Initiated Clinical Study (Cohort Construction), Pudong New Area Health Commission. Construction of AI-Driven Preterm Birth Prediction Model and Novel Biomarkers Based on Multicenter Maternal-Infant Cohort (No. 2026-PWDL-14). 2026.01–2028.12. 600,000 RMB. Ongoing. Principal Investigator.
3. 国家自然科学基金面上项目，巨噬细胞源性 TNF-α 介导羊膜上皮细胞 ZO-1 相分离在未足月胎膜早破中的作用与机制研究，82571948，2026.01-2029.12，49 万，在研，主持。General Program of the National Natural Science Foundation of China. Role and Mechanism of Macrophage-Derived TNF-α-Mediated ZO-1 Phase Separation in Amniotic Epithelial Cells in Preterm Premature Rupture of Membranes (No. 82571948). 2026.01–2029.12. 490,000 RMB. Ongoing. Principal Investigator.
4. 浦东新区卫健委研究者发起临床研究项目，基于多中心母婴队列联合 AI 驱动早产预测模型构建与新型标志物探索，无，2026.01-2028.12，60 万，在研，主持。Researcher-Initiated Clinical Study, Pudong New Area Health Commission. Construction of AI-Driven Preterm Birth Prediction Model and Novel Biomarkers Based on Multicenter Maternal-Infant Cohort. 2026.01–2028.12. 600,000 RMB. Ongoing. Principal Investigator.
5. 浦东新区临床医学新质专科建设项目，早产全周期防治，2024-PWXZ-15，2025.01-2027.12，1390 万，在研，主持。New Quality Clinical Specialty Construction Project of Pudong New Area. Full-Cycle Prevention and Treatment of Preterm Birth (No. 2024-PWXZ-15). 2025.01–2027.12. 13,900,000 RMB. Ongoing. Principal Investigator.
6. 浦东新区卫生系统医学人才培养计划，领先人才，PWR12024-03，2024.12-2027.11，30 万，在研，主持。Medical Talent Training Program of Pudong New Area Health System, Leading Talent (No. PWR12024-03). 2024.12–2027.11. 300,000 RMB. Ongoing. Principal Investigator.
7. 上海市卫健委科普引领人才专项，早识早防：早产全方位健康科普赋能计划，JKKPYL-2024-A10，2024.07-2026.06，30 万，在研，主持。Special Program for Science Popularization Leading Talents of Shanghai Municipal Health Commission. Early Recognition and Prevention: Comprehensive Health Science Popularization Empowerment Program for Preterm Birth (No. JKKPYL-2024-A10). 2024.07–2026.06. 300,000 RMB. Ongoing. Principal Investigator.
8. 海南省科技厅科普项目，聚焦孕产安全，促进健康海南，KPHD202425，2024.02-2025.02，8 万，结题，主持。Science Popularization Project of Hainan Provincial Department of Science and Technology. Focusing on Maternal Safety to Promote Healthy Hainan (No. KPHD202425). 2024.02–2025.02. 80,000 RMB. Completed. Principal Investigator.
9. 浦东新区科普项目，早产防治健康科普视频制作，KPZ2024-19，2023.10-2024.09，16 万，结题，主持。Science Popularization Project of Pudong New Area. Production of Health Science Popularization Videos for Preterm Birth Prevention and Treatment (No. KPZ2024-19). 2023.10–2024.09. 160,000 RMB. Completed. Principal Investigator.
10. 浦东新区卫健委学科建设项目，早产重点专科，KWZzK2022-11，2023.01-2026.12，40 万，在研，主持。Discipline Construction Project of Pudong New Area Health Commission. Key Specialty of Preterm Birth (No. KWZzK2022-11). 2023.01–2026.12. 400,000 RMB. Ongoing. Principal Investigator.
11. 院级临床研究课题，基于孕妇队列的 “全链式” 早产预测 - 预防体系的构建，2022.01-2025.12，20 万，在研，主持。Hospital-Level Clinical Research Project. Construction of a "Full-Chain" Preterm Birth Prediction and Prevention System Based on Pregnant Women Cohort. 2022.01–2025.12. 200,000 RMB. Ongoing. Principal Investigator.
12. 市级科普专项，生殖健康系列科普，2022.07-2023.06，10 万，结题，主持。Municipal-Level Science Popularization Program. Series of Science Popularization on Reproductive Health. 2022.07–2023.06. 100,000 RMB. Completed. Principal Investigator.
13. 浦东新区卫健委联合攻关项目，基于 RFAS 评分构建自发性早产预警体系的研究及应用推广，PW2021D-11，2021.12-2024.11，20 万，结题，主持。Joint Research Project of Pudong New Area Health Commission. Development and Application of Spontaneous Preterm Birth Early Warning System Based on RFAS Scoring (No. PW2021D-11). 2021.12–2024.11. 200,000 RMB. Completed. Principal Investigator.
14. 上海市卫健委科研课题，早产早期筛查与综合规范化体系的建立及推广应用，2019SY044，2019.07-2022.06，60 万，结题，主持。Research Project of Shanghai Municipal Health Commission. Establishment and Application of a Comprehensive Standardized System for Early Screening of Preterm Birth (No. 2019SY044). 2019.07-2022.06. 600,000 RMB. Completed. Principal Investigator.
5年内代表性 SCI 论文（Representative SCI Papers in the Past 5 Years）：
1. Liu Y, Meng L, Ni X, et al. Comparison of two strategies to prevent preterm birth in twins complicated by cervical insufficiency: a retrospective cohort study. J Matern Fetal Neonatal Med. 2026;39(1):2601448. (Corresponding author, IF 1.7)
2. Meng L, Yang J, Gao Y, et al. The role of amniotic epithelial cells in preterm birth: mechanisms and clinical implications. Front Cell Dev Biol. 2025;13:1590212. (Co-corresponding author, IF 4.3)
3. Wang Y, Wang W, Lei S, et al. Association between history of pregnancy loss and preterm birth: the mediating role of maternal anxiety. BMC Pregnancy Childbirth. 2025;25(1):958. (Corresponding author, IF 2.7)
4. Meng L, Meng M, Zhang R, et al. Microbiome-producing SCFAs are associated with preterm birth via trophoblast function modulation. mBio. 2024;15(12):e02702-24. (Co-corresponding author, IF 4.7)
5. Ni X, Su X, Shi Y, et al. Association between adenomyosis volume and adverse perinatal outcomes: multicenter cohort study. Ultrasound Obstet Gynecol. 2024;64(5):678-686. (Corresponding author, IF 6.3)
6. Ni X, Liu M. Rapid remission of severe impetigo herpetiformis following combined treatment with secukinumab and corticosteroids. Eur J Dermatol. 2023;33(6):712-713. (Corresponding author，IF 1.5)
7. Fan X, Ma Y, Zhu Y, et al. The potential presence of infection may be indicated through non-invasive prediction of procalcitonin and C-reactive protein levels within the initial three days after cervical cerclage: a retrospective case-control study. BMC Pregnancy Childbirth. 2024;24(1):474. (Corresponding author，IF 2.7)
8. Ru P, Ni X, Xu W, et al. Perinatal outcomes in patients undergoing repeat cerclage: A retrospective case series study. Int J Gynaecol Obstet. 2023. (Corresponding author，IF 2.4)
9. Xu W, Ni X, Liu Y, et al. Transvaginal cerclage for prevention of preterm birth in twin pregnancies with cervical dilatation or shortening: A prospective observational study. Int J Gynaecol Obstet. 2023. (Corresponding author，IF2.4)
10. Yu G, Yang L, Liu M, et al. Extreme Temperature Exposure and Risks of Preterm Birth Subtypes Based on a Nationwide Survey in China. Environ Health Perspect. 2023;131(8):087009. (Co-first author, IF 9.8)
11. Ni XT, Wang WS, Liu Y, et al. The Bradykinin System Contributes to the Regulation of Prostaglandin-Endoperoxide Synthase 2 Expression in Human Amnion Fibroblasts: Implications for Term and Preterm Birth. Front Endocrinol (Lausanne). 2022;13:873727. (Co-corresponding author，IF4.6)
12. Ye J, Chen Y, Yang H, et al. A nationwide cross-sectional survey of episiotomy practice in China. Lancet Reg Health West Pac. 2021;19:100345. (Co-corresponding author, IF 8.1)
13. Liu M, Xue M, Yang Q, et al. Association between migration status and caesarean section delivery based on a modified Robson classification in China. BMC Pregnancy Childbirth. 2021;21(1):215. (First author,IF 2.7)
14. Yang X, Liu M, Li M, et al. Epigenetic modulations of noncoding RNA: a novel dimension of Cancer biology. Mol Cancer. 2020;19(1):64. (Co-corresponding author,IF 33.9)
15.Liu M, Xue M, Yan X, et al. Factors associated with C-Section Delivery based on a modified Robson Classification in China: Does migration status matter. BMC Pregnancy Childbirth. (First author,IF 2.7)
