复杂白内障的精准诊疗策略及其发病机制研究

遗传性眼病致病基因鉴定及靶向干预的基础与转化研究

眼科人工智能及医工交叉研究

Precision Diagnosis and Treatment Strategies and Pathogenesis on Complex Cataracts

Basic and Translational Research on Pathogenic Gene Identification and Targeted Intervention for Hereditary Eye Diseases

Artificial Intelligence in Ophthalmology and Interdisciplinary Medical - Engineering Research

主任医师，副教授，博士生导师，同济大学附属第十人民医院眼科行政主任、眼科教研室主任、规培基地主任。

中华医学会眼科学分会白内障及屈光手术学组委员；上海市医学会眼科专科分会委员兼秘书（常务委员）；上海市医学会白内障学组组长；上海市医师协会眼科委员会委员；上海市神经科学学会视觉神经科学分会委员会副主任委员；中国研究型医院学会眼科学与视觉科学专业委员会委员；中国康复医学会视觉康复专委会青年工作组委员；中国医学装备协会眼科专业委员会委员；教育部科技管理专家库成员；上海市老龄工作专家库成员；全国研究生教育评估监测专家库专家；SCI期刊Journal of Personalized Medicine（JCR Q2）编委、SCI期刊（JCR Q1）Annals of Medicine、Experimental Eye Research、Journal of Cataract and Refractive Surgery、Diagnostics、Scientific Reports审稿人

Chief physician, Associate Professor, Doctoral Supervisor， Administrative Director of Ophthalmology, Director of Ophthalmology Teaching and Research Section, and Director of Standardized Training Base, Tenth People’s Hospital affiliated to Tongji University.

Member of Cataract & Refractive Surgery Sub Committee, Chinese Ophthalmological Committee, Chinese Medical Association; Member and Secretary of Ophthalmology Branch Committee, Shanghai Medical Association (Standing Committee Member); Chair of Cataract Group, Ophthalmological Committee, Shanghai Medical Association; Member of Ophthalmology Committee, Shanghai Medical Doctor Association; Vice Chairman of the Visual Neuroscience Branch of the Shanghai Society for Neuroscience; Committee Member, Ophthalmology and Visual Science Professional Committee, Chinese Research Hospital Association; Youth Working Group Member, Visual Rehabilitation Specialty Committee, Chinese Association of Rehabilitation Medicine; Committee Member, Ophthalmology Specialty Committee, China Association of Medical Equipment; Member of the Expert Database for Science and Technology Management, Ministry of Education, China; Member of the Expert Database for Aging Work, Shanghai; Expert in the National Graduate Education Evaluation and Monitoring Expert Database; Editorial Board Member of SCI-indexed Journal of Personalized Medicine (JCR Q2), and Reviewer for SCI-indexed journals (JCR Q1) including Annals of Medicine, Experimental Eye Research, Journal of Cataract and Refractive Surgery, Diagnostics, and Scientific Reports.

复旦大学眼科学博士，获上海市卫健委银蛇奖提名（上海市卫生系统青年人才最高奖）、上海市医学会“青年菁英”、上海市优秀青年医师、教育部博士研究生学术新人奖、复旦大学“十佳百优”优秀青年医生、上海市科技进步二等奖（先天性白内障的微创治疗）。入选上海青年医师培养资助计划、复旦大学青年临床科学家培养计划。研究方向为复杂白内障及晶状体疾病的精准诊疗及发病机制研究，主持各类项目及人才计划共16项，包括国家自然科学基金项目2项、省部级课题4项。第一/通讯作者发表论文46篇，其中SCI论文36篇，包括JCR 1区论文22篇、中科院顶刊8篇。临床研究4次发表于中科院一区期刊美国眼科学临床顶刊Am J Ophthalmol、及欧洲眼科学顶刊Invest Ophthalmol Vis Sci、白内障领域权威SCI期刊J Cataract Refract Surg并受到主编述评引用。基础研究创新性成果2次发表于中科院TOP期刊Free Radic Biol Med、Metabolism（IF=16.7） 等。副主译学术论著1部，参编学术论著9部，包括英文论著1部。

Doctor degree of Ophthalmology, Fudan University. Dr. Zheng has been nominated for the Silver Snake Award of the Shanghai Municipal Health Commission (the highest distinction for young talents in Shanghai's healthcare system); awarded Young Elite, Shanghai Medical Association; Outstanding Young Physician of Shanghai; Doctoral Academic Rising Star Award, Ministry of Education; "Top Ten and Hundred Excellent" Outstanding Young Doctor of Fudan University, and Second Prize of the Shanghai Science and Technology Progress Award (Minimally Invasive Treatment of Congenital Cataracts). She has been selected as Recipient of the Shanghai Young Physician Training and Support Program and Recipient of the Fudan University Young Clinical Scientist Training Program. Her research direction is the precision diagnosis and treatment and pathogenesis of complex cataracts and lens diseases. Dr. Zheng is Principal investigator of 16 projects and talent programs, including 2 National Natural Science Foundation of China (NSFC) projects and 4 provincial and ministerial-level projects. Dr. Zheng has published 46 papers as the first author or corresponding author, including 36 SCI papers, among which there are 22 papers in JCR Q1 and 8 papers in top journals of the Chinese Academy of Sciences. Clinical research papers have been published 4 times in top-tier journals including Am J Ophthalmol (CAS Q1, official journal of the American Academy of Ophthalmology), Invest Ophthalmol Vis Sci (official journal of the Association for Research in Vision and Ophthalmology), and J Cataract Refract Surg (the leading journal in cataract surgery), with one paper receiving editorial commentary. Two innovative fundamental research results have been published in CAS Top-tier journals including Free Radic Biol Med and Metabolism (IF = 16.7). Dr. Zheng served as associate chief translator of 1 academic monograph and participated in the compilation of 9 academic monographs, including 1 English monograph.

Publications（Past 5 years）:

1. Tianyu Zheng#, Peimin Lin#, Ao Miao#, Yating Tang, Yongxiang Jiang*, Jie Xu*. Comparative analysis of corneal endothelial cell loss after phacoemulsification in microcornea versusnormal-sized corneas. Clin Ophthalmol. 2026 Jul 8:20:616945.（IF=2.2, JCR Q2）

2. Yaoyan Qiu#, Wenting Cai#, Zihan Xie#, Chenxi Li, Fan Yang, Yiyong Qian*, Jingwu Song*, Tianyu Zheng*. Integrated analysis of the aqueous humor microbiome and lens capsule transcriptome in high myopia cataract: a pilot study. Front Med (Lausanne). 2026 Jun 16:13:1845205. （IF=3.6, JCR Q1）

3. Ruoyi Lin#, Zixin Cai#, Tianyu Zheng#, Yan Wu, Zihang Xu, Yunhong Luo, Feng Liang, Manhui Zhu*, Jing Yu*, Wenting Cai*. Macrophage-derived SPP1 promotes subretinal fibrosis by YAP1 phase separation in retinal pigment epithelium. Metabolism. 2026 Aug:181:156648.（IF=16.7, JCR Q1）

4. Fan Yang#, Jie Xu#, Peimin Lin, Mingyang Wang*, Tianyu Zheng*. Changes in and correlations between pupil parameters and visual quality after cataract surgery. Int J Ophthalmol. 2026 Aug 18;19(8):1518-1525.（IF=2.0, JCR Q3）

5. Xuehao Cui, Jiajia Yuan, Qiuchen Zhao, Patrick Yu-Wai-Man, Tianyu Zheng*. Sleep Regularity and Age-Related Eye Diseases: Prospective Analyses with Retinallmacing and Multimorbidity Assessment in the UK Biobank. Sleep. 2026 Apr 22:zsag111.（IF=7.0，JCR Q1）

6. Fan Yang#, Peimin Lin#, Dongjin Qian#, Jie Xu, Ao Miao, Jiahui Chen, Tianyu Zheng*. Laser Peripheral Iridotomy for Treating Recurrent Uveitis-Glaucoma-Hyphema Plus Syndrome with a Scleral Fixed Intraocular Lens: A Case Report. BMC Ophthalmol. 2026 Mar 21;26(1):222. (IF= 1.7, JCR Q3)

7. Yuye Zhang, Shiyu Tang, Zihan Xie, Fan Yang, Peimin Lin, Chenxi Li, Tianyu Zheng*. Influence of Ocular Biometric Parameters on IOL Power Calculation Accuracy in Short and Normal Axial Length Eyes.Ophthalmol Ther. 2026 Apr;15(4):1407-1423. (IF = 4.2, JCR Q1)

8. Tianyi Shen, Ruoyi Lin, Tianyu Zheng*, Jing Yu*, Wenting Cai*. Succinate Mediates Immune‐Angiogenic Response by Activating Macrophage M2 Polarization in Oxygen‐Induced Retinopathy. FASEB J. 2026 Feb 28;40(4):e71545. (IF=4.2, JCR Q1)

9. Mingyang Wang, Dongmei Li, Guodong Liu*, Tianyu Zheng*. A Prospective Validation Study of an Automated Ocular1 Proptosis Device in Thyroid Eye Disease. The Journal of Craniofacial Surgery. J Craniofac Surg. 2026 Jan 19. (IF = 1, JCR Q3)

10. Ao Miao#, Fan Yang#, Tianhui Chen#, Dongjin Qian, Yongxiang Jiang, Jie Xu*, Tianyu Zheng*. Lens Thickness-to-Anterior Chamber Depth Ratio: A Biometric Determinant of Chamber Angle Width in Han Chinese Cataract Patients. Invest Ophthalmol Vis Sci. 2025 Mar 3;66(3):42. (IF=5.0，JCR Q1)

11. Peimin Lin#, Jie Xu#, Fan Yang#, Dan Li, Rong Zhang, Yongxiang Jiang*, Tianyu Zheng*. Elevated concentrations of amyloid-β oligomers and their proapoptotic effects on age-related cataract. FASEB J. 2024 Sep;38(17):e23861. (IF=4.4，JCR Q1)

12. Jie Xu#, Fan Yang#, Peimin Lin, Dongjin Qian, Tianyu Zheng*. Biometric factors associated with the postoperative visual performance of a multifocal intraocular lens. Heliyon. 2024 May 24;10(11):e31867. (IF=3.4, JCR Q1)

13. Ao Miao#, Jie Xu#, Kai Wei#, Peimin Lin, Liangliang Niu, Yumeng Shi, Dongjin Qian, Yi Lu, Yongxiang Jiang*, Tianyu Zheng*. Comparison of B-Scan ultrasonography, ultra-widefield fundus imaging, and indirect ophthalmoscopy in detecting retinal breaks in cataractous eyes. Eye (Lond). 2024 Sep;38(13):2619-2624. (IF=2.8, JCR Q1)

14. Peimin Lin#, Jie Xu#, Ao Miao#, Yi Lu*, Yongxiang Jiang*, Tianyu Zheng*. Novel compound heterozygous variants in LTBP2 associated with relative anterior microphthalmos. 2024 Nov;34(6):1750-1760. (IF=1.5, JCR Q3)

15. Ao Miao#, Peimin Lin#, Dongjin Qian, Jie Xu, Yi Lu, Tianyu Zheng*. Association between Endothelial Cell Density and Corneal Thickness in Medium, Short, and Long Eyes of Han Chinese Cataract Patients. Am J Ophthalmol. 2024 Jun:262:10-18. (IF=4.1, JCR Q1)

16. Ao Miao#, Peimin Lin#, Shaolong Ren#, Jie Xu, Fan Yang, Dongjin Qian, Yi Lu, Tianyu Zheng*. Influence of Ocular Biometry Parameters on the Predictive Accuracy of IOL Power Formulas in Patients with High Myopia. Ophthalmol Ther. 2024 Jan;13(1):435-448. (IF=2.6，JCR Q2)

17. Peimin Lin#, Jie Xu#, Ao Miao#, Canqing Xu, Dongjin Qian, Yi Lu*, Tianyu Zheng*. A Comparative Study on the Accuracy of IOL Calculation Formulas in Nanophthalmos and Relative Anterior Microphthalmos. Am J Ophthalmol. 2023 Jan;245:61-69. (IF=4.1, JCR Q1)

后续发表letter reply：

Tianyu Zheng#, Ao Miao, Peimin Lin, Jie Xu, Canqing Xu, Dongjin Qian, Yi Lu*. Reply to Comment on: A Comparative Study on the Accuracy of IOL Calculation Formulas in Nanophthalmos and Relative Anterior Microphthalmos. Am J Ophthalmol. 2023;251:198. (IF=4.1, JCR Q1)

18. Jie Xu#, Peimin Lin#, Shaohua Zhang, Yi Lu*, Tianyu Zheng*. Risk factors associated with intraocular lens decentration after cataract surgery. Am J Ophthalmol.2022 Oct;242:88-95. (IF=4.1, JCR Q1)

19. Yating Tang#, Jie Xu#, Yi Lu*, Tianyu Zheng*. Three Novel Mutations of Microphthalmos Identified in Two Chinese Families. Phenomics. 2022 May 7;2(4):254-260. (IF=3.7, JCR Q2)

20. Ao Miao#, Yating Tang#, Xiangjia Zhu, Dongjin Qian, Tianyu Zheng*, Yi Lu*. Associations between Anterior Segment Biometry and High Axial Myopia in 3438 Cataractous Eyes in the Chinese Population. BMC Ophthalmol. 2022 Feb 12;22(1):71. (IF= 1.7，JCR Q3)

21. Jie Xu#, Dan Li#, Yi Lu*, Tianyu Zheng*. Aβ monomers protect lens epithelial cells against oxidative stress by upregulating CDC25B. Free Radic Biol Med. 2021 Nov 1:175:161-170. (IF=7.1, JCR Q1)

22. Jie Xu, Tianyu Zheng*, Yi Lu*. Comparative Analysis of Visual Performance and Astigmatism Tolerance with Monofocal, Bifocal, and Extended Depth-of-Focus Intraocular Lenses Targeting Slight Myopia. J Ophthalmol. 2020 Oct 24:2020:9283021. (IF=1.8，JCR Q3)

23. Tianyu Zheng#, Jie Xu#, Yi Lu*. Comparison of the accuracy of four Pentacam corneal astigmatism values in non-toric pseudophakic eyes. Graef Arch Clin Exp. 2020 Apr;258(4):795-803. (IF=2.4，JCR Q2)