同济大学附属同济医院放疗科主任,医学博士,博士后,博士生导师,省部级卫生拔尖人才。致力于从事肿瘤放化疗的临床与转化医学研究,熟练掌握常见肿瘤的综合治疗,擅长头颈部肿瘤、肺癌、消化道肿瘤及妇科肿瘤放疗为主的综合治疗,专业基础扎实。主持国家自然基金3项(青年基金1项,面上项目2项),省部级项目6项,为首授权国家发明专利3项,美国专利1项。以第一作者/通讯作者发表SCI论文60余篇,相关论文发表在《Int J Radiat Oncol Biol Phys》《Radiotherapy and Oncology》《Advanced Science》《ACS Nano》《Cancer Letters》《Oncogene》等权威期刊,以第一完成人或主要完成人获得省部级及厅级科技奖励5项,带教硕博士生20余人。多次获得“最受欢迎研究生导师”称号。
【主持项目】
1、国家自然科学基金面上项目,82073339、REV7招募Aly调控热休克蛋白HSP70家族影响食管癌放射敏感性的机制研究、2021/01-2024/12、56万元、已结题、主持。
2、国家自然科学基金面上项目,81773224、尿嘧啶转移酶TUT4修饰miR-132/212调控放射性食管损伤的机制研究、2018/01-2021/12、55万元、已结题、主持。
3、国家自然科学基金青年基金,81402518、USP11去泛素化调控Nrf2/ARE通路对食管癌放射敏感性的影响及机制研究、2015/01-2017/12、23万元、已结题、主持。
【近三年发表论文】
1) Fuquan Zhang, Bingtao Huang, Yiming Xu, Guohong Cao, Mingjing Shen, Changmin Liu, Judong Luo* .MISP Suppresses Ferroptosis via MST1/2 Kinases to Facilitate YAP Activation in Non-Small Cell Lung Cancer. Advanced Science,2025 Apr;12(16):e2415814 (Q1,责任通讯作者,IF=14.1)
2) Xu B, Liu J, Fang M, Zhu H, Zhang Y, Zhang H, Lu X, Luo J*.Multicenter deep learning-based automatic delineation of CTV and PTV in uterine malignancy CT imaging.Radiother Oncol. 2025 Oct 19;214:111212. (责任通讯作者,Q1,放疗TOP期刊,IF=5.3)
3) Duan W, Liu H, Luo J*.Predicting Single-Cell Drug Sensitivity Utilizing Adaptive Weighted Features for Multi-Source Domain Adaptation.IEEE J Biomed Health Inform. 2025,29(8):6043-6054. (Q1,唯一通讯作者,IF=6.8)
4) Zhao M, Jin Y, Yan Z, He C, You W, Zhu Z, Wang R, Chen Y, Luo J*, Zhang Y, Yao Y.The splicing factor QKI inhibits metastasis by modulating alternative splicing of E-Syt2 in papillary thyroid carcinoma.Cancer Lett. 2024 Nov 1;604:217270. (Q1,共同通讯作者,IF=10.1)
5) Liu H, Zhang Y, Luo J*.Contrastive learning-based histopathological features infer molecular subtypes and clinical outcomes of breast cancer from unannotated whole slide images.Comput Biol Med. 2024;170:107997. (Q1,唯一通讯作者,IF=6.3)
6) Luo J, Gao Q, Wang M, Liu H, Zhu H.Single-cell and spatial transcriptome characterize coinhibitory cell-cell communications during histological progression of lung adenocarcinoma.Front Immunol. 2024 Oct 15;15:1430163. (Q1,第一作者,IF=5.9)
7) Li Q, Feng S, Yu Z, Wang Y, Tian L, Geng H, Guo C, Ning F, Luo J*, Liu C.Amelioration of Acute Radiation Dermatitis in Breast Cancer Patients by a Bioadhesive Barrier-Forming Gel (Episil): A Single-Center, Open, Parallel, Randomized, Phase I/II Controlled Trial.Clin Pharmacol Ther. 2024;115(5):1085-1091. (Q1,共同通讯作者,IF=5.5)
8) Yang Y, Xu B, Zhu H, Sun W, Liang A, Luo J.Combining CAR-T therapy with radiotherapy or not in refractory/relapsed diffuse large B-cell lymphoma: A comparative study.Clin Transl Radiat Oncol. 2025 Sep 2;55:101041. doi: 10.1016/j.ctro.2025.101041.(责任通讯作者)
9) Cai F, Li Y, Liu H, Luo J.Single-cell and Spatial Transcriptomic Analyses Implicate Formation of the Immunosuppressive Microenvironment during Breast Tumor Progression.J Immunol. 2024 Nov 1;213(9):1392-1401. (责任通讯作者)
10) Liu M, Sun Z, Tang Y, Zhang S, Luo J*. The Regulation of Exosome-Mediated miR-132-3p/miR-132-3p-UUU on Radiation-Induced Esophageal Injury. Radiat Res. 2023;200(2):151-161. (唯一通讯作者)
11) Wu J, Liu Y, Huang X, Cheng Y, Qian Z, Ni X, Chen S, Lin M, Luo J*. LncRNA DGCR5 Silencing Enhances the Radio-Sensitivity of Human Esophageal Squamous Cell Carcinoma via Negatively Regulating the Warburg Effect. Radiat Res. 2023;199(3):264-272. (责任通讯作者)
12) Tang Y, Yuan Q, Zhao C, Xu Y, Zhang Q, Wang L, Sun Z, Cao J, Luo J*, Jiao Y*.Targeting USP11 may alleviate radiation-induced pulmonary fibrosis by regulating endothelium tight junction.Int J Radiat Biol. 2022;98(1):30-40. (共同通讯作者)