计算调控基因组学与系统生物医学

以重大疾病的发生发展机制为核心科学问题，综合运用疾病动物模型和临床样本，结合基因组、转录组、蛋白组等多组学高通量数据，开展计算生物学与实验相结合的系统生物医学研究。

【主要研究方向】

1、开发生物医学问题导向的算法与多组学分析流程；

2、聚焦于肿瘤、肺纤维化、自身免疫性疾病、神经系统疾病等，基于动物模型和临床队列，系统挖掘关键基因与信号通路，解析其在疾病发生发展中的调控机制，并通过分子与细胞实验验证其功能，为精准诊疗策略和新药靶点提供理论基础与候选分子。

Computational Regulatory Genomics and Systems Biomedicine

We focus on the fundamental mechanisms underlying the initiation and progression of major human diseases. By integrating disease animal models and clinical specimens with high-throughput multi-omics datasets—including genomics, transcriptomics, and proteomics—we conduct systems-level biomedical research that combines computational biology with experimental validation.

【Major research directions】

(1) Developing algorithms and multi-omics analysis pipelines tailored to specific biomedical questions. We design and implement computational methods tailored to specific biomedical questions, enabling efficient and integrative analysis of diverse multi-omics datasets.

(2) Identifying novel pathogenic genes, pathways, and regulatory mechanisms underlying major diseases. Focusing on cancer, pulmonary fibrosis, autoimmune diseases, and neurological disorders, we leverage both animal models and clinical cohorts to systematically identify critical genes and signaling pathways. We further elucidate their regulatory roles in disease initiation and progression and validate their functions through molecular and cellular experiments, thereby providing mechanistic insights and candidate targets for precision medicine and therapeutic development.

同济大学附属肺科医院副研究员

同济大学高等研究院研究员

全国研究生教育评估监测专家库专家

学术编委，BMC Medical Genomics

Cell reports、Advanced science、hLife、British Journal of Pharmacology等期刊审稿人

Associate Research Fellow, Shanghai Pulmonary Hospital, Tongji University

Research Fellow, Institute for Advanced Study, Tongji University

Expert Member, National Expert Panel for Graduate Education Evaluation and Monitoring

Editorial Board Member, BMC Medical Genomics

Ad Hoc Reviewer for multiple international journals, including Cell Reports, Advanced Science, hLife, and the British Journal of Pharmacology

近年来研究工作聚焦在基于重大疾病临床样本以及疾病动物细胞模型的新颖调控因子发掘、分子机制解析以及疾病干预研究。作为第一作者或通讯作者（含共同）在Med、Nature Ecology & Evolution、 Nature Communications、 Advanced Science、Molecular Biology & Evolution、Cell Reports、Autophagy、Nucleic Acids Research、PLoS Genetics、Science China Life Sciences等期刊发表研究论文20余篇，其中影响因子>10的论文10篇，中科院一区文章16篇，引用次数超3200次。主持国家自然科学基金面上项目、青年项目等, 作为课题骨干与科技部重点研发与江苏省重点项目。

【近3年通讯作者(含共通)研究型论文】

1. Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination. 2024. Med. IF=12.8 (最后通讯)

2. Integrative analysis identifies region- and sex-specific gene networks and Mef2c as a mediator of anxiety-like behavior. 2024. Cell reports. IF=7.5 (最后通讯)

3．Local exosome inhibition potentiates mild photothermal immunotherapy against breast cancer. 2025. Advanced Science. IF=15.1(共通排二)

4. CSNK1A1/CK1alpha suppresses autoimmunity by restraining the CGAS-STING1 signaling. 2024. Autophagy. IF=14.6 (共通排二)

5. Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation. 2023. Autophagy. IF=16.016 (共通排二)

6. UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation. 2022. Autophagy. IF=13.3 (共通排二)

7. STING signaling in islet macrophages impairs insulin secretion in obesity. 2024. Sci China Life Sci. IF=9.1(共通排二)

8. m(6)A-mediated modulation coupled with transcriptional regulation shapes long noncoding RNA repertoire of the cGAS-STING signaling. 2022. CSBJ. IF= 6.15 (最后通讯）

9. IsomiRome analysis reveals dysregulation of 5’isomiRs during SARS-CoV-2 infection. 2025. CSBJ. IF= 4.1 (最后通讯）

10. Transcriptome-based characterization of 3’2’-cGAMP signaling mediated immune responses. 2024. CSBJ. IF= 4.5 (最后通讯）

11. Time-course RNA-Seq profiling reveals isoform-level gene expression dynamics of the cGAS-STING pathway. 2022. CSBJ. IF=6.15 (独立通讯)

Dr. Hu’s research has focused on the discovery of novel pathogenic genes, elucidation of molecular mechanisms, and development of potential therapeutic strategies using clinical samples from major human diseases, together with disease-related cellular and animal models. He has published more than 20 research articles as senior author (first author or corresponding author, including co-first and co-corresponding author) in high-impact journals such as Med, Nature Ecology & Evolution, Nature Communications, Advanced Science, Molecular Biology & Evolution, Cell Reports, Autophagy, Nucleic Acids Research, PLoS Genetics, and Science China Life Sciences. Among these publications, 10 papers have an impact factor greater than 10, 16 are categorized as CAS Zone 1, and his work has been cited more than 3,200 times. Dr. Hu has served as Principal Investigator for multiple projects funded by the National Natural Science Foundation of China, including both General Program and Young Scientists Fund projects. In addition, he has participated as a key contributor in national Key R&D Programs supported by the Ministry of Science and Technology, as well as major provincial research initiatives funded by Jiangsu Province.

Publication list in the Past Three Years (Corresponding Author or Co-Corresponding Author)

1. Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination. 2024. Med. IF=12.8 (Corresponding Author)

2. Integrative analysis identifies region- and sex-specific gene networks and Mef2c as a mediator of anxiety-like behavior. 2024. Cell reports. IF=7.5 (Corresponding Author)

3．Local exosome inhibition potentiates mild photothermal immunotherapy against breast cancer. 2025. Advanced Science. IF=15.1(Co-Corresponding Author)

4. CSNK1A1/CK1alpha suppresses autoimmunity by restraining the CGAS-STING1 signaling. 2024. Autophagy. IF=14.6 (Co-Corresponding Author)

5. Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation. 2023. Autophagy. IF=16.016 (Co-Corresponding Author)

6. UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation. 2022. Autophagy. IF=13.3 (Co-Corresponding Author)

7. STING signaling in islet macrophages impairs insulin secretion in obesity. 2024. Sci China Life Sci. IF=9.1(Co-Corresponding Author)

8. m(6)A-mediated modulation coupled with transcriptional regulation shapes long noncoding RNA repertoire of the cGAS-STING signaling. 2022. CSBJ. IF= 6.15 (Corresponding Author）

9. IsomiRome analysis reveals dysregulation of 5’isomiRs during SARS-CoV-2 infection. 2025. CSBJ. IF= 4.1 (Corresponding Author）

10. Transcriptome-based characterization of 3’2’-cGAMP signaling mediated immune responses. 2024. CSBJ. IF= 4.5 (Corresponding Author）

11. Time-course RNA-Seq profiling reveals isoform-level gene expression dynamics of the cGAS-STING pathway. 2022. CSBJ. IF=6.15 (Corresponding Author)