肿瘤学;肿瘤放射治疗与放射生物学;肿瘤治疗电场及电磁复合场抗肿瘤机制;高LET粒子辐射生物学;肿瘤免疫与放疗增敏机制;间充质干细胞(MSCs)辐射应答及骨髓微环境重建
Oncology; Radiation oncology and radiation biology; Tumor Treating Fields (TTFields) and electromagnetic field-based anticancer mechanisms; high-LET particle radiation biology; tumor immunology and radiosensitization; radiation responses of mesenchymal stromal cells (MSCs) and bone marrow microenvironment remodeling
同济大学附属上海市第四人民医院放疗科副主任,主治医师;中国医疗器械行业协会肿瘤粒子治疗器械与技术专业委员会青年委员;中国老年保健协会肿瘤电场治疗分会青年委员;Frontiers in Oncology专题“Radiation and Tumour Treating Fields: Mechanisms and Applications in Oncology”负责人;BMC Cancer、Journal of Drug Targeting等期刊审稿人
Associate Chief Physician, Department of Radiation Oncology, Shanghai Fourth People’s Hospital affiliated to Tongji University; Youth Committee Member of the Oncology Particle Therapy Equipment and Technology Committee, China Association for Medical Devices Industry; Youth Committee Member of the Tumor Treating Fields Branch, China Association of Gerontology and Geriatrics; Topic Coordinator for Frontiers in Oncology (“Radiation and Tumour Treating Fields: Mechanisms and Applications in Oncology”); Reviewer for BMC Cancer, Journal of Drug Targeting, etc.
近年来围绕肿瘤放疗、电磁场抗肿瘤机制及放射生物学开展系统研究。主持及参与上海市白玉兰人才计划(浦江项目)等课题多项。以第一作者或通讯作者在 Cancer Letters、APL Bioengineering、BMC Cancer、Frontiers in Oncology 等期刊发表SCI论文10余篇,其中:
Cancer Letters(IF=10.1):共同第一作者,研究高LET粒子辐射对间充质干细胞干性维持机制
APL Bioengineering(IF=6.6):通讯作者,揭示TTFields与微管电生理相互作用机制
BMC Cancer(IF=3.4):责任通讯作者,发现甲状腺功能异常可预测免疫治疗疗效
Frontiers in Oncology:共同第一作者/通讯作者,开展TTFields细胞内电场模拟研究
相关研究涵盖肿瘤电场治疗机制、电磁场与放疗协同、高LET辐射生物效应及肿瘤免疫调控等方向。
Research focuses on radiation oncology, tumor treating fields (TTFields), electromagnetic field-based cancer therapy, and radiation biology. As principal investigator, has led projects including the Shanghai Magnolia Talent Program (Pujiang Project) and participated in multiple grants.
Has published over 10 SCI-indexed papers as first or corresponding author in journals such as Cancer Letters, APL Bioengineering, BMC Cancer, and Frontiers in Oncology. Representative works include:
Cancer Letters (IF=10.1): Co-first author, demonstrating preservation of stemness in MSCs after high-LET irradiation
APL Bioengineering (IF=6.6): Corresponding author, elucidating electrodynamic interactions between TTFields and microtubules
BMC Cancer (IF=3.4): Corresponding author, identifying thyroid dysfunction as a predictor of immunotherapy efficacy
Frontiers in Oncology: Co-first/corresponding author, computational modeling of intracellular electric fields under TTFields
Research covers TTFields mechanisms, electromagnetic field–radiotherapy synergy, high-LET radiation biology, and tumor immunomodulation.