上海市第二届医师协会理事
上海市医师协会第二届病理科医师分会会长
中国医师协会呼吸分会病理工作委员会副主任委员
国家呼吸病临床医学研究中心“全国呼吸病临床-病理诊治联盟”副会长
上海市病理专培基地专家委员会组长
上海市同济医院国家病理住培基地主任
上海市同济医院病理专培基地主任
上海市医师协会病理科医师分会胸部病理学组组长
上海市医学会呼吸分会呼吸病理学组组长
中国合格评定国家认可委员会医学实验室主任评审员
上海市医学会临床病理质控委员会委员
上海市医学会医疗鉴定专家库专家
上海市抗癌协会肿瘤病理专业委员会委员
国家自然科学基金面上项目通讯评议专家
《Journal of Cytology》审稿专家
《中华病理学杂志》审稿专家
《中华医学学杂志》审稿专家
《中华结核和呼吸杂志》审稿专家
Director of the Second Shanghai Medical Association
President of the Second Pathology Branch of Shanghai Medical Doctor Association
Vice Chairman of the Pathology Working Committee of the Respiratory Branch of the Chinese Medical Doctor Association
Vice President of National Respiratory Disease Clinical-Pathology Diagnosis and Treatment Alliance of National Respiratory Disease Clinical Research Center
Leader of Expert Committee of Shanghai Pathology Specialized Training Base
Director of National Pathology Residential Training Base of Shanghai Tongji Hospital
Director of Pathology Specialized Training Base of Shanghai Tongji Hospital
Head of the Thoracic Pathology Group of the Pathologists Branch of the Shanghai Medical Association
Head of Respiratory Pathology Group, Respiratory Branch of Shanghai Medical Association
Chief Assessor of Medical Laboratory of China National Accreditation Service for Conformity Assessment
Member of the Clinical Pathology Quality Control Committee of Shanghai Medical Association
Expert of Shanghai Medical Association Medical Appraisal Expert Database
Member of the Tumor Pathology Professional Committee of Shanghai Anti-Cancer Association
National Natural Science Foundation of China General Project Communication Review Expert
Reviewer of "Journal of Cytology"
Reviewer of "Chinese Journal of Pathology"
Reviewer of "Chinese Journal of Medical Science"
Reviewer of "Chinese Journal of Tuberculosis and Respiration"
全国知名呼吸病理专家,上海市同济医院病理科主任,具有丰富的临床病理诊断经验。在呼吸系统疾病和纵隔疾病,特别是在肺癌、间皮瘤、结核病和结节病、间质性肺疾病(ILD)、职业性尘肺等疾病的诊断上达到国内领先水平。同时,致力于间质性肺病(ILD)的基础和临床研究工作。承担和参加完成省部级以上科研课题20余项。其中主持国家自然科学基金面上项目1项,国家卫计委科研发展基金项目1项,上海市科委医学重点项目2项,上海市卫计委医学重点项目1项。发表学术论文200余篇,第一作者或通信作者发表SCI收录论文50余篇,中华系列杂志40余篇。多次受邀为《中华病理学杂志》和《中华结核和呼吸杂志》等核心期刊撰写ILD相关的基础及临床专论和述评。作为执笔人和通信作者,撰写“非特异性间质性肺炎病理诊断中国专家共识(草案)”和“中国特发性肺纤维化临床⁃影像⁃病理诊断规范”分别发表在《中华结核和呼吸杂志》(2018. 41(11):833-839)和《中华病理学杂志》(2018.47(2):81-86)。
A well-known respiratory pathologist in the country, with rich experience in clinical pathology diagnosis. In the diagnosis of respiratory diseases and mediastinal diseases, especially lung cancer, mesothelioma, tuberculosis and sarcoidosis, interstitial lung disease (ILD), occupational pneumoconiosis and other diseases, it has reached the leading domestic level. At the same time, it is committed to the basic and clinical research work of interstitial lung disease (ILD). Undertake and participate in the completion of more than 20 scientific research projects at or above the provincial and ministerial level. Among them, he presided over 1 general project of the National Natural Science Foundation of China, 1 scientific research development fund project of the National Health and Family Planning Commission, 2 medical key projects of the Shanghai Municipal Science and Technology Commission, and 1 medical key project of the Shanghai Health and Family Planning Commission. He has published more than 200 academic papers, the first author or corresponding author has published more than 30 SCI papers, and more than 40 Chinese journals. He has been invited many times to write basic and clinical monographs and reviews related to ILD for core journals such as the “Chinese Journal of Pathology” and the “Chinese Journal of Tuberculosis and Respiratory Medicine”.
承担科研项目:
1. 2022-2024年国家自然科学基因面上项目“环境污染物BaP诱导的GPRC5A通过调控巨噬细胞极化参与IPF发病的机制研究”(项目编号,57万,第一责任人)
2. 2019-2022年上海市科学技术委员会 科研计划项目(课题):“SHOX2和 RASSF1A基因甲基化联合检测在肺癌细 胞学早期病理诊断中的临床应用价值”(项目编号 19411964700,20万,主持)
3. 2019-2022年上海市科学技术委员会:“基于苯并(a)芘诱导的GPRC5A/TGF-β信号通 路在特发性肺纤维化中的调控作用及机制研究” (项目编号 :19ZR1448500,20万,主持)
4. 2014-2016年上海市卫生局医学重点专项基金 “诱导痰石蜡包埋块技术在下呼吸道非肿瘤性疾病诊断中的应用价值”(项目编号20134034,10万,第一责任人)
5. 2013-2015年国家卫计委医药卫生科技发展研究中心课题“细胞DNA定量分析技术在肺癌及癌前病变早期检测中的临床应用”(项目编号W2013GJ61,第一责任人,50万,已结题)
6. 2009-2013年上海市科学技术委员会医学重点科技攻关专项基金“生物芯片技术检测细胞因子在IPF中的表达及意义”(项目编号09411951600,25万,主持,已结题)
7. 2003-2007上海市科学技术发展基金课题:“特发性间质性肺炎的ATS/ERS分类与临床的相关性研究”(项目编号034119868,20万,主持,已结题)
8. 2021-2024 上海市同济医院临床研究培育重点项目“应用于胸腹水良恶性肿瘤鉴别的多基因甲基化组合的筛选和临床应用价值”(项目编号 ITJ(ZD)2105,50万,主持)
科研成果及奖励:
1.2021年上海市医学科技三等奖,第一完成人
2.2009年上海市医学科技三等奖(证书号20080322)
3.2012年上海市医学科技三等奖(证书号2012032604)
4.2013年上海市科技进步三等奖(证书号20134178-3-R04)
5.2013年上海医学科技奖(成果推广,证书号2013T0204)
6.2013年“生物芯片技术检测细胞因子在IPF中的表达及意义” 被鉴定为上海市科学技术成果,登记号:9312013J1245。
7.2009年“特发性间质性肺炎的ATS/ERS分类与临床的相关性研究” 被鉴定为上海市科学技术成果,登记号:931209Y0646
8.第四届“仁心医者-上海市杰出专科医师奖”
学术论文:
部分代表论文:
1.Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer. Clin Cancer Res.2018; 24(19):4854-4864. (Corresponding author, IF=13.801)
2.Aberrant phosphorylation of SMAD4 Thr277-mediated USP9x-SMAD4 interaction by free fatty acids promotes breast cancer metastasis. Cancer Research,2017;(Co-first author, IF=13.312)
3.GPRC5A reduction contributes to pollutant benzo[a]pyrene injury viaaggravating murine fibrosis, leading to poor prognosis of IIP patients. Science of the Total Environment 739 (2020) 139923 (Corresponding author, IF=10.753)
4.Performance Evaluation of SHOX2 and RASSF1A Methylation for the Aid in Diagnosis of Lung Cancer Based on the Analysis of FFPE Specimen. Frontiers in Oncology.2020. (Corresponding author, IF=5.738)
5.Analysis of Microarray-Identified Genes and MicroRNAs Associated with Idiopathic Pulmonary Fibrosis.Mediators Inflamm,2017,2017: 1804240. Published online 2017 May 14. doi: 10.1155/2017/1804240(Corresponding author,IF=4.529)
6.Severe Acute Respiratory Syndrome (SARS) and venous thromboembolism in multiple organs. Am J Respir Crit Care Med,2010;182(3): 436-437. (First author, IF=30.528)
7.Histology subtypes and polyp size are associated with synchronous colorectal carcinoma of colorectal serrated polyps: a study of 499 serrated polyps. Am J Cancer Res,2015;(1):363-374. (Corresponding author, IF=5.942)
8.Liu Q , Qiao M , Lohinai Z , et al. CCL19 associates with lymph node metastasis and inferior prognosis in patients with small cell lung cancer[J]. Lung Cancer, 2021, 162:194-202.(IF=6.081)
9.Chinese expert consensus on the standardized procedure and technique of transbronchial cryobiopsy.[J]. Journal of thoracic disease, 2019, 11(12):4909-4917(IF=3.005)
10.中国医师协会呼吸医师分会病理工作委员会.非特异性间质性肺炎病理诊断中国专家共识(草案).中华结核和呼吸杂志.2018. 41(11):833-839. (通信作者)
11.中华医学会病理学分会胸部疾病学组. 中国特发性肺纤维化临床⁃影像⁃病理诊断规范. 中华病理学杂志.2018.47(2):81-86
12.经支气管冷冻活检技术临床应用专家共识[J].中华结核和呼吸杂志,2019(06):405-412.
13.张素霞,周红,宇小婷,朱旭友,韩非,袁诚,易祥华.全自动DNA定量分析检测对恶性胸腔积液诊断的价值.中华病理学杂志,2015;(通信作者).
14.吴运瑾,易祥华.美国胸会/欧洲呼吸学会(2013)特发性间质性肺炎的国际多学科分类解读.中华病理学杂志,2015;44(3):158-163.
15.顾盼,方霞,易祥华等.特发性肺纤维化和特发性非特异性间质性肺炎中细胞因子的表达及分析.中华结核和呼吸杂志,2014,37(9):664-670. (通信作者).
16.张宗梅,易祥华.1,25(OH)2D3抗肺纤维化及其机制和研究进展.中华病理学杂志,2013; (通信作者).
17.方霞,顾盼,易祥华等.β-catenin表达下调对非小细胞肺癌细胞株PC9/AB2吉非替尼耐药性的影响.中华病理学杂志,2013;(通信作者)
18.易祥华,何国钧,刘鸿瑞,李惠萍.呼吸性细支气管炎伴间质性肺病和脱屑性间质性肺炎的比较分析.中华结核和呼吸杂
19.罗本芳,李惠萍,易祥华,陶巨蔚,吕寒静,方霞,张宗梅,张龙,任胜祥,楮海青,李霞,曾郁.肺泡蛋白沉积症患者痰液沉淀物的超微结构特点及其诊断价值.中华结核和呼吸杂志,2012;(通信作者)