麻醉治疗：失眠及相关疑难病的有效麻醉治疗及其机制

Anesthesia therapy: effective anesthetic treatment of insomnia and related intractable diseases and its mechanism

中国医药教育协会麻醉专业委员会 常务委员

the Anesthesiology Committee of the Chinese Medical Education Association Standing member

1.Xu X, Yu B, Lv Y, Cai Q, Li M, Li G, Chen S, Li Q. Epidural block with lidocaine ameliorates kidney function deterioration and fibrosis of chronic kidney disease in rats. 利多卡因硬膜外阻滞改善大鼠慢性肾病肾功能恶化和纤维化。 Am J Med Sci. 2024:S0002-9629(24)01413-7.

2.Xu X, Yu B, Lv Y, Cai Q, Li M, Li G, Li Q. Efficacy and safety of epidural block with lidocaine for refractory severe plaque psoriasis: An open-label pilot study in real world setting. 利多卡因硬膜外阻滞治疗难治性严重斑块状银屑病的有效性和安全性：一项在现实世界环的开放标签研究J Dermatol. 2024;51(5):696-703.

3.Yin Q, Sun L, Cai X, Lou F, Sun Y, Wang B, Jiang B, Bao L, Li X, Song N, Tang S, Bai J, Wang Z, Wu Y, Zhou H, Wang H, Yu B, Li Q, Wang H. Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling-Mediated Sensory Neuron-Dendritic Cell Communication. 利多卡因通过阻断致病性 CGRP 信号介导的感觉神经元-树突状细胞通讯来改善银屑病J Invest Dermatol. 2022;142(8):2173-2183.

4.国家自然科学基金 痒觉中枢敏化在硬膜外阻滞调控神经-免疫互作治疗银屑病瘙痒症状中的作用机制 NSFC The mechanism of central itch sensitization in the regulation of neuro-immune interaction through epidural block for pruritus symptom面上项目 编号 82471291 2025.1-2028.12