陈潜，博士，副研究员，同济大学附属上海市第四人民医院科研部副部长，上海市青年科技启明星，上海市东方英才（青年），上海市麻醉与脑功能调控重点实验室PI。长期聚焦临床关键科学问题，致力于新型催化药物与功能化益生菌的开发，并探索其在神经认知障碍及肠道疾病的作用机制和应用潜力。在科研发表方面，以第一作者或通讯作者（含共同）在Signal Transduction and Targeted Therapy、Advanced Functional Materials、ACS Nano、Biomaterials、Journal of Controlled Release等国际知名期刊上发表SCI论文15篇，其中10篇影响因子大于10，包括3篇封面论文。单篇最高影响因子达52.7，最高引用200余次。已获授权专利6项。作为项目负责人，主持国家自然科学基金青年科学基金项目（C类）、上海市东方英才计划青年项目、上海市青年科技启明星计划、中国博士后科学基金第70批面上资助、2020年上海市“超级博士后”激励计划、上海市卫生健康委员会医学新技术研究与转化种子计划项目等多项科研项目。目前兼任Military Medical Research（IF 22.9）科学编辑，以及Cancer Drug Resistance、Medical Gas Research、Oncology and Translational Medicine等期刊的青年编委。
一、代表性论文：
(1) Miao Wang, Qian Chen*, Ziyi Cheng, Zideng Dai, Tan Wu, Bicheng Han, Fuhao Jia, Cheng Li,* and Hangrong Chen*, Advanced Functional Materials, 2025, e02635. （共同通讯作者，IF：19.0，中科院一区）
(2) Qing Liu, Qian Chen*, Xi Deng, Yutong Zhu, Zhangpeng Shi, Runjie Miao, Ming Ma, Nian Ran, Cheng Li, Hangrong Chen*, Fe/Co Bimetallic Nanozyme Disrupting Tumorous Self-Regulatory Pathways to Potentiate Ferroptosis. Chemical Engineering Journal, 2024, 152753.（共同通讯作者，IF：13.2，中科院一区）
(3) Xinyue Wang, Qian Chen*, Yefei Zhu, Kairuo Wang, Yongliang Chang, Xiawei Wu, Weichao Bao, Hangrong Chen, Yang Zhang*, Huanlong Qin*; Destroying Pathogen-Tumor Symbionts Synergizing with Catalytic Therapy of Colorectal Cancer by Biomimetic Protein-supported Single-Atom Nanozyme. Signal Transduction And Targeted Therapy, 2023, 8:277（共同通讯作者，IF：52.7，Q1，中科院一区，封面文章）
(4) Jiahao Du#; Mengting Zhou#; Qian Chen*; Yichao Tao; Jun Ren; Yang Zhang*; Huanlong Qin*; Disrupting Intracellular Iron Homeostasis by Engineered Metal-Organic Framework for Nanocatalytic Tumor Therapy in Synergy with Autophagy Amplification-Promoted Ferroptosis, Advanced Functional Materials, 2023, 2215244. （共同通讯作者；IF：19.0，中科院一区）
(5) Xiao Qu#, Fang Yin#, Manman Pei#, Qian Chen*, Yuanyuan Zhang, et al., Hangrong Chen, Yang Zhang*, Huanlong Qin*; Modulation of Intratumoral Fusobacterium nucleatum to Enhance Sonodynamic Therapy for Colorectal Cancer with Reduced Phototoxic Skin Injury, ACS Nano, 2023, 17, 11466−11480. （共同通讯作者；IF：16.0，中科院一区，封面文章）
(6) Qian Chen#, Yefei Zhu#, Kairuo Wang, Xinyue Wang, Yuanyuan Zhang, Mengting Zhou, Jiahao Du, Xiao Qu, Zhangpeng Shi, Yang Zhang*, Yu Chen*; Huanlong Qin*, Clearing Intratumoral Bacteria to Augment Tumor-Therapeutic Response by Engineering Antimicrobial Dendritic Mesoporous Silica Nanomedicine. Nano Today, 2023, 52 101994.（第一作者；IF：10.9，中科院二区）
(7) Kairuo Wang#, Qian Chen#, Li Ding#, Yefei Zhu, et al., Yuanyuan Zhang, Yang Zhang*, Huanlong Qin*, and Yu Chen*; Mucoadhesive probiotic-based oral microcarriers with prolonged intestinal retention for inflammatory bowel disease therapy, Nano Today, 2023, 50, 101876.（共同第一作者；IF：10.9，中科院二区）
(8) Yifu Feng#, Qian Chen#, Chong Jin#, Yanyun Ruan, Qi Chen, Weidong Lin, Chumeng Zhu, Tinglin Zhang, Yang Zhang*, Jie Gao*, Jinggang Mo*. Microwave-activated Cu-doped zirconium metal-organic framework for a highly effective combination of microwave dynamic and thermal therapy, Journal of Controlled Release, 2023, 361:102-14. （共同第一作者；IF：11.5，中科院一区）
(9) Wang Miao; Chen Qian*; Xu Dong; Yang Zebin; Chen Jufeng; Zhang Yang*; Chen Hangrong*; Self-cycling redox nanoplatform in synergy with mild magnetothermal and autophagy inhibition for efficient cancer therapy, Nano Today, 2022, 43: 101374. （共同通讯作者；IF：10.9，中科院二区）
(10) Chen Qian#, Kangan Li#, Shihui Wen, et al., Guixiang Zhang*, Xiangyang Shi*. Targeted CT/MR dual mode imaging of tumors using multifunctional dendrimer-entrapped gold nanoparticles, Biomaterials. 2013;34:5200-9. （第一作者；IF：12.9，Q1，高被引论文，引用次数200余次，中科院一区
二、近年主持的主要科研项目及人才计划：
1、国家自然科学基金青年基金项目C，国家自然科学基金委员会，2025年1月-2027年12月，30万，主持；
2、上海市东方英才计划青年项目，上海市人才工作局，主持；
3、上海市青年科技启明星项目，上海市科学技术委员会，2024年12月-2027年11月，40万，主持；
4、上海市超级博士后激励计划，上海市人力资源和社会保障局，2021年1月-2023年5月，30万元，主持；
5、2025年“虹口青年英才”，虹口区人才工作局，主持；
6、医学新技术研究与转化种子计划项目，上海市卫生健康委员会，2026年1月-2028年12月，40万，主持；
7、中国博士后科学基第70批金面上资助二等，中国博士后科学基金会，2021年11月-2023年6月，8万元，主持；
8、 科研启动专项经费，上海市第四人民医院，2024年1月-2026年12月，30万，主持；
9、 学科助推计划基础研究项目，上海市第四人民医院，2024年3月-2026年2月，10万，主持。
Qian Chen, Ph.D.
Associate Research Fellow
Associate Director, Research and Development Department
Shanghai Fourth People's Hospital Affiliated to Tongji University
Honors and Titles:
Shanghai Rising-Star Program (Young Scientist)
Shanghai Oriental Talents (Youth)
Principal Investigator, Shanghai Key Laboratory of Anesthesia and Brain Functional Modulation
Research Focus:
Dr. Chen has long been dedicated to addressing critical clinical scientific issues, focusing on the development of novel catalytic drugs and functionalized probiotics. He innovatively proposed the "Catalytic Microecology-Therapy" and has extensively explored its potential applications in neurocognitive disorders and intestinal diseases.
Publications:
As first author or corresponding author (including co-authored roles), Dr. Chen has published 15 SCI papers in internationally renowned journals such as Signal Transduction and Targeted Therapy, Advanced Functional Materials, ACS Nano, Biomaterials, and Journal of Controlled Release. Among these, 10 papers have an impact factor (IF) > 10, including 3 cover papers. His highest IF paper reaches 52.7, with a maximum citation count of over 200.
Patents:
Authorized patents: 6
Editorial Roles:
Scientific Editor: Military Medical Research (IF: 22.9)
Youth Editorial Board Member: Cancer Drug Resistance, Medical Gas Research, Oncology and Translational Medicine
Research Grants (as Principal Investigator):
National Natural Science Foundation of China (Youth Program, Category C), 2025-2027, 300,000 CNY.
Shanghai Oriental Talents Program (Youth Project).
Shanghai Rising-Star Program, 2024-2027, 400,000 CNY.
Shanghai "Super Postdoctoral" Incentive Program, 2021-2023, 300,000 CNY.
2025 "Hongkou Youth Talents," Hongkou District Talent Bureau.
Seed Program for Medical New Technology Research and Translation, Shanghai Municipal Health Commission, 2026-2028, 400,000 CNY.
70th Batch of China Postdoctoral Science Foundation (General Program, Second Class), 2021-2023, 80,000 CNY.
Research Start-up Fund, Shanghai Fourth People's Hospital, 2024-2026, 300,000 CNY.
Discipline Boosting Program (Basic Research Project), Shanghai Fourth People's Hospital, 2024-2026, 100,000 CNY.
Selected Publications:
Wang, M.; Chen, Q.; Cheng, Z.; Dai, Z.; Wu, T.; Han, B.; Jia, F.; Li, C.; Chen, H.* Advanced Functional Materials, 2025, e02635. (Co-corresponding author, IF: 19.0, CAS Q1)
Liu, Q.; Chen, Q.; Deng, X.; Zhu, Y.; Shi, Z.; Miao, R.; Ma, M.; Ran, N.; Li, C.; Chen, H. Chemical Engineering Journal, 2024, 152753. (Co-corresponding author, IF: 13.2, CAS Q1)
Wang, X.; Chen, Q.; Zhu, Y.; Wang, K.; Chang, Y.; Wu, X.; Bao, W.; Chen, H.; Zhang, Y.; Qin, H.* Signal Transduction and Targeted Therapy, 2023, 8:277. (Co-corresponding author, IF: 52.7, CAS Q1, Cover Paper)
Du, J.#; Zhou, M.#; Chen, Q.; Tao, Y.; Ren, J.; Zhang, Y.; Qin, H.* Advanced Functional Materials, 2023, 2215244. (Co-corresponding author, IF: 19.0, CAS Q1)
Qu, X.#; Yin, F.#; Pei, M.#; Chen, Q.; Zhang, Y.; et al.; Chen, H.; Zhang, Y.; Qin, H.* ACS Nano, 2023, 17, 11466−11480. (Co-corresponding author, IF: 16.0, CAS Q1, Cover Paper)
Chen, Q.#; Zhu, Y.#; Wang, K.; Wang, X.; Zhang, Y.; Zhou, M.; Du, J.; Qu, X.; Shi, Z.; Zhang, Y.; Chen, Y.; Qin, H.* Nano Today, 2023, 52, 101994. (First author, IF: 10.9, CAS Q2)
Wang, K.#; Chen, Q.#; Ding, L.#; Zhu, Y.; et al.; Zhang, Y.; Qin, H.; Chen, Y. Nano Today, 2023, 50, 101876. (Co-first author, IF: 10.9, CAS Q2)
Feng, Y.#; Chen, Q.#; Jin, C.#; Ruan, Y.; Chen, Q.; Lin, W.; Zhu, C.; Zhang, T.; Zhang, Y.; Gao, J.; Mo, J.* Journal of Controlled Release, 2023, 361:102-14. (Co-first author, IF: 11.5, CAS Q1)
Wang, M.; Chen, Q.; Xu, D.; Yang, Z.; Chen, J.; Zhang, Y.; Chen, H.* Nano Today, 2022, 43, 101374. (Co-corresponding author, IF: 10.9, CAS Q2)
Chen, Q.#; Li, K.#; Wen, S.; et al.; Zhang, G.; Shi, X. Biomaterials, 2013, 34, 5200-9. (First author, IF: 12.9, CAS Q1, Highly Cited Paper, Citations: 200+)
