围术期神经认知功能障碍

postoperative neurocognitive dysfunction

同济大学附属上海市第四人民医院教务部部长兼临床技能虚拟仿真综合实训中心主任、麻醉与围术期医学科副主任。美国佛罗里达大学Shands医院临床麻醉访问学者。中华麻醉与围术期医学培训工程秘书长。中华医学会围术期大数据学组委员。中华医学会麻醉分会十三届神经外科麻醉学组委员，上海市医学会麻醉分会十一届神经外科麻醉学组副组长。吴阶平医学基金会麻醉管理学院教导处主任，同济大学“青年干部培养计划第一期”学员。

Director of Academic Affairs at Shanghai Fourth People's Hospital, Tongji University, concurrently holding the positions of Deputy Director of the Department of Anesthesia and Perioperative Medicine and Director of the Clinical Skills Virtual Simulation Training Center. As a visiting scholar at the Department of Clinical Anesthesia, Shands Hospital, University of Florida, USA. The professional portfolio includes key leadership roles as Secretary-General of the Chinese Anesthesia and Perioperative Medicine Training Program, Member of the Big Data in Perioperative Medicine Group under the Chinese Medical Association, Member of the Neurosurgical Anesthesia Group (13th Committee) of the Chinese Society of Anesthesiology, Vice-Chair of the Neurosurgical Anesthesia Group (11th Committee) of Shanghai Society of Anesthesiology, and Director of Education at the Anesthesia Management Institute under Wu Jieping Medical Foundation. Research focus spans postoperative neurocognitive disorders in Parkinson's disease, anesthesia therapy for childhood autism, and inflammatory immune mechanisms.

长期聚焦帕金森患者术后神经认知障碍、儿童孤独症麻醉治疗、炎症免疫开展临床和基础课题研究，主持国家自然科学基金、上海市科委基础重点项目、院临床创新项目、院学科助推重大项目、院科研启动基金等9项。获国家发明专利4项，软件著作10个，以第一作者或通讯作者发表SCI论著18篇。科技成果转化3项，转让金额50万元。

【Research Focus】

1. Postoperative neurocognitive dysfunction in Parkinson's disease

2. Anesthesia-based therapeutic strategies for childhood autism spectrum disorder (ASD)

3. Inflammatory immune mechanisms in neurological disorders

【Participated projects with research awards】

1. Roles and mechanisms of plasma MicroRNA-572 in elderly patients with post-operation cognitive dysfunction (Financed by the National Natural Science Foundation of China, 100,000 Yuan, 2014-2014 ,PI)

2. TRIM negatively regulates microglia activation and inflammatory cytokines production and its roles in pathophysiology(Financed by the National Natural Science Foundation of China, 200,000 Yuan, 2018-2020 ,PI)

3. Effect of scalp nerve block combined with intercostal nerve block on the quality of recovery in patients with Parkinson’s disease after deep brain stimulation: a prospective, randomized controlled trial.(Financed by Innovative Program of First Affiliated Hospital of Naval Medical University 300,000 Yuan, 2020YXK013,2021-2024,PI)

4. SIRT3 is improved by regulating microglial metabolic reprogramming mechanism of postoperative neurocognitive dysfunction(Financed by Discipline Boosting Program of Shanghai Fourth People's Hospital 300,000 Yuan,SY-XKZT-2022-1003.2023-2025,PI)

【Publication Record】

1．Dan Zhanga; Na Li; Yuanyuan Wang; Wenbin Lu; Yongyan Zhang; Yuanjie Chen; Xiaoming Denga; Xiya Yu.Methane ameliorates post-operative cognitive dysfunction by inhibiting microglia NF-κB/MAPKs pathway and promoting IL-10 expression in aged mice.International Immunopharmacology, 2019, 71(2019): 52-60.

2．Wenbin Lu; Zhengyu Jiang; Jie Huang; Jinjun Bian; Xiya Yu. Preoperative Serum Metabolites and Potential Biomarkers for Preoperative Cognitive Decline in Elderly Patients. Frontiers in Psychiatry, 2021, 12(665097).

3．Wenbin Lu, Keqin Zhang, Xinning Chang, Xiya Yu, Jinjun Bian .The association between systemic Immune-inflammation index and postoperative decline in elderly patients .Clinical Interventions in Aging. 2022 May 3;17:699-705.

4．Yuanqiang Dai, Ying Sheng, Yu Deng, Heng Wang, Zhenzhen Zhao, Xiya Yu, Tao Xu. Circ_0000647 promotes cell injury by modulating miR-126-5p/TRAF3 axis in oxygen-glucose deprivation and reperfusion-induced SK-N-SH cell model.Int Immunopharmacol. 2022 Mar;104:108464.

5．Ying Sheng;Hui Wang; Xinning Chang; Peipei Jin; Shengwei Lin; Shuang Qian; Jian Xie; Wenbin Lu; Xiya Yu, Effect of Scalp Nerve Block Combined with Intercostal Nerve Block on the Quality of Recovery in Patients with Parkinson's Disease after Deep Brain Stimulation: Protocol for a Randomized Controlled Trial, Brain Sci,2022 Jul 29;12(8):1007.

6．Weiji Qiu; Qiqing Shi; Fang Chen; Qian Wu; Xiya Yu; Lize Xiong, The derived neutrophil to lymphocyte ratio can be the predictor of prognosis for COVID-19 Omicron BA.2 infected patients, Front Immunol, 2022 Nov 2;13:1065345.

7．Wenbin Lu;Xinning Chang; Lulong Bo; Yiqing Qiu; Mingyang Zhang; Jiali Wang; Xi Wu; Xiya Yu, Risk Factors for Delirium after Deep Brain Stimulation Surgery under Total Intravenous Anesthesia in Parkinson's Disease Patients, Brain Sci,2022 Dec 22;13(1):25.

8．Dongmei Hong; Hui Zhang; Yong Yu; Huijie Qian; Xiya Yu; Lize Xiong. Total muscle-to-fat ratio influences urinary incontinence in United States adult women: a population-based study. Front Endocrinol (Lausanne). 2024 Mar 28:15:1309082.

9．Wei Wu;Wenbin Lu;Dongmei Hong;Xiya Yu, Lize Xiong.Association Between Hemoglobin-Albumin-Lymphocyte-Platelet Index and Mortality in Hospitalized COVID-19 Omicron BA.2 Infected Patients.Infect Drug Resist. 2024 Apr 12:17:1467-1476.

10．Wenbin Lu; Hui Wang; Shengwei Lin; Xinning Chang; Jiali Wang; Xi Wu; Xiya Yu. The association between the fibrinogen-to-albumin ratio and delirium after deep brain stimulation surgery in Parkinson's disease. Front Med (Lausanne). 2024 Apr 19:11:1381967.

11. Wenbin Lu; Xinning Chang; Wei Wu; Peipei Jin; Shengwei Lin; Lize Xiong; Xiya Yu.The Scalp Nerve Block Combined with Intercostal Nerve Block Improves Recovery After Deep Brain Stimulation in Patients with Parkinson's Disease: A Prospective, Randomized Controlled Trial. Clin Interv Aging.2024Nov 8:19:1881-1889.

【Transformation of scientific and technological achievements】

Achievements: 3 projects successfully transferred

Total Transfer Amount: ¥500,000 (CNY)