一、主持或参加科研项目及人才计划：
国家自然科学基金 面上项目，81971814，回肠FXR-FGF19/15信号通路在脓毒症胆汁淤积性肝损伤中的调控机制研究，55万，2020.01-2023.12。已结题，主持。
上海市浦东新区卫生系统卫生英才（拔尖人才）培养计划，2025PDWSYCBJ-04，肠道菌群代谢物缓解脓毒症肠道损伤的机制研究，80万，2025.07-2028.6，已立项，主持。
上海市浦东新区卫生系统学科带头人培养计划，PWRd2020-06，脓毒症肠-肝轴紊乱的病理机制研究。20万，2021.01-2024.12。在研，主持。
上海市2023年度“科技创新行动计划”医学创新研究专项，23Y11908300，基于第4代认知AI技术胆汁酸代谢组学分析在脓毒症早期识别中的预测作用的临床研究。25万，2023.12-2026.11。在研，主持。
同济大学附属东方医院特色专科疼痛科负责人，2024-DFTS-006, 750万，在研，主持。
上海市浦东新区卫生和计划生育委员会临床高峰学科建设项目，急危重症学科，疼痛亚专科研究基金，PWYgf2021-03，中西医结合急重症镇痛多中心临床研究，30万，2021.12.01-2024.11.30。在研，第一负责人。
上海市浦江人才计划，2020PJD050，肠道MyD88促脓毒症肠-肝轴紊乱的病理机制研究。30万，2020.11-2022.12。结题，主持。
江西省自然科学基金 面上项目，20192BAB205013，原发性硬化性胆管炎肝细胞凋亡致肠道菌群紊乱介导肠-肝轴损伤的病理机制研究，6万， 2019.01.01-2021.12.31。结题，主持。
上海市疼痛学青年基金，RFSH201811-01, 三氧水灌肠疗法治疗纤维肌痛综合征的临床研究。3万，2018.12-2021.12。结题，主持。
同济大学附属东方医院引进人才科研启动基金，2018DF10, 胆汁淤积性肝硬化肝细胞NLRP3炎性体激活致肠道菌群轴紊乱的病理机制研究。30万，2020.12- 2025.11。在研，主持。
上海市浦江人才，20PJ1416800，重症监护室的病毒防控数据治理系统。30万，2020.10-2023.7。结题，第二负责人。
同济大学附属东方医院临床研究项目，DFLC2022020，背根神经节早期神经纤维化调控治疗胸部带状疱疹后神经痛的临床研究，40万，2023.01-2027.12。在研，第二负责人。
二、代表性论著（*共同第一作者，#通讯作者）：
Jiaqi Lin, Xuejiao Zeng, Zehua Su, Xin Li, Yongze Yu, Shuwen Qian, Qianhao Hou, Wenying Duan, Zetian Wang, Chunzheng Liu, Jinyuan Zhang, Changshun Huang, Lijun Liao. Hyodeoxycholic acid relieves neuropathic pain by activating farnesoid X receptor signaling, Journal of Advanced Research, 2025, https://doi.org/10.1016/j.jare.2025.07.017. (通讯作者，IF 13/Q1)
Zetian Wang, Ningning Hu, Longqiu Yang, Qing Wang, Chunzheng Liu, Wenying Duan, Jiaqi Lin, Jinyuan Zhang, Xiuqin Yu, Changchun Huang, Yuling Li, Lijun Liao. Immunotherapy strategy for treating inflammatory bowel disease based on a nanozyme/total glucosides of paeony hybrid materials. Advanced Composites and Hybrid Materials. 2025，8:160-169. https://doi.org/10.1007/s42114-025-01249-6. (通讯作者，IF 21.8/Q1)
Xuejiao Zeng, Jiaqi Lin, Botao Liu, Zehua Su, Yongze Yu, Xin Li, Wenying Duan, Chunzheng Liu, Qianhao Hou, Jinyuan Zhang, Longqiu Yang, Xiaodong Liu, Bifa Fan, Lijun Liao. Hydrogen-rich water alleviates neuropathic pain through the modulation of bile acid/Takeda G-protein-coupled receptor 5-mediated autophagy. Pain. 2025 Oct 24. doi: 10.1097/j.pain.0000000000003830. (通讯作者，IF 5.5/Q1)
Shuwen Qian, Zehua Su, Jiaqi Lin, Qianhao Hou, Xiaomei Wang, Yuling Li, Jieying Wang, Changchun Huang, Zetian Wang, Francisco Javier Cubero, Xiangrui Wang, Lijun Liao. Inhibition of Farnesoid-x-receptor signaling during abdominal sepsis by dysbiosis exacerbates gut barrier dysfunction. Cell Commun Signal. 2025, 236 (23). https://doi.org/10.1186/s12964-025-02224-w. (通讯作者，IF 8.9/Q1)
Lijun Liao, Kai Markus Schneider, Mick Frissen, Till Strowig, Hanns-Ulrich Marschall, Huan Su, Daniela Kroy, Annika Wahlström, Eric J.C. Galvez, Antje Mohs, Jin Peng, Julia Jung, Johanna Reißing, Alexander Wree, Henning Wolfgang Zimmermann, Veerle Bieghs, Thomas Longerich, Christian Liedtke, Francisco Javier Cubero, Christian Trautwein. Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis. Gut. 2019 Aug;68(8):1477-1492. doi: 10.1136/gutjnl-2018-316670 (IF25.8/Q1)
Francisco Javier Cubero*, Jin Peng*, Lijun Liao*, Huan Su, Gang Zhao, Miguel Eugenio Zoubek, Ricardo Macias-Rodriguez, Astrid Ruiz-Margain, Johanna Reißing, Henning W. Zimmermann, Nikolaus Gassler, Tom Luedde, Christian Liedtke, Maximilian Hatting, Christian Trautwein. Inactivation of caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis. J Hepatol. 2018 Dec;69(6):1326-1334. DOI: 10.1016/j.jhep.2018.08.015 (* 共同第一作者，IF 26.8/Q1)
Qing Wang, Chunzheng Liu, Baitian Li, Xiuqin Yu, Xiaodong Liu, Jinyuan Zhang, Zetian Wang, Lijun Liao, Xiaodong Liu. Ozone controls the metabolism of tryptophan protecting against sepsis-induced intestinal damage by activating aryl hydrocarbon receptor. World Journal of Gastroenterology. 2025;31(17). doi:10.3748/wjg.v31.i17.105411 (通讯作者，IF 5.4/Q1)
Zetian Wang, Wei Luo, Qing Wang, Chunzheng Liu, Yanshan Gong, Baitian Li, Xuejiao Zeng, Jiaqi Lin, Zehua Su, Xin Li, Yongze Yu, Zhongmin Liu, Ling Gao, Lijun Liao. hUCMSCs Regulate Bile Acid Metabolism to Prevent Heart Failure–Induced Intestinal Injury by Inhibiting the Activation of the STAT3/NF-κB/MAPK Signaling Pathway via TGR5. Food Frontiers. 2024, 10 November 2024. Nov 20:11:1434767.https://doi.org/10.1002/fft2.516. (通讯作者，IF 6.9/Q1)
Hongwei Fang, Qianhao Hou, Wei Zhang, Zehua Su, Jinyuan Zhang, Jingze Li, Jiaqi Lin, Zetian Wang, Xiuqin Yu, Yu Yang, Qing Wang，Xin Li, Yuling Li, Guilun Hu, Shun Li, Xiangrui Wang, Lijun Liao#. Fecal Microbiota Transplantation Improves Clinical Symptoms of Fibromyalgia: A Randomized, Controlled Study. Journal of Pain. 2024 Sep;25(9):104535. doi: 10.1016/j.jpain.2024.104535. (通讯作者，IF 4.859/Q1)
Tao Zhang, Higuo Guo, Xianhui Cheng, Rongmu Xia, Sicong Lai, Lijun Liao. Protective properties of Ophiopogonin D in DSS-induced colitis: insights into microbiota modulation. Inflammopharmacology. 2024 Oct; 32(5):3553-3570. doi: 10.1007/s10787-024-01531-x. Epub 2024 Jul 22. (通讯作者，IF 4.6/Q2)
Qianhao Hou, Jinyuan Zhang, Zehua Su, Xiaomei Wang, Hongwei Fang, Shuwen Qian, Haobing Shi, Qing Wang, Yuling Li, Jiaqi Lin, Xiangrui Wang, Zetian Wang, Lijun Liao. Clinical Trial of Ozonated Water Enema for the Treatment of Fibromyalgia: A Randomized, Double-Blind Trial. Pain Physician. 2025 Jan;28(1):E13-E22. PMID: 39903016. (通讯作者，IF 2.5/Q2)
Baitian Li, Zetian Wang, Qing Wang, Chunzheng Liu, Wenying Duan, Jiaqi Lin, Jinyuan Zhang, Qianhao Hou, Lijun Liao. DL-tryptophan alleviates sepsis-related acute liver injury via AhR activation. J Inflamm Res. 2025 Jul 22;18:9669-9678. doi: 10.2147/JIR.S526621. PMID: 40727464. (通讯作者，IF 4.2/Q2)
Yongze Yu, Wen Xu, Xin Li, Xuejiao Zeng, Zehua Su, Qing Wang, Shun Li, Chunzheng Liu, Zetian Wang, Shanjin Wang, Lijun Liao#, Jinyuan Zhang#. MRI Radiomics based on paraspinal muscle for prediction postoperative outcomes in lumbar degenerative spondylolisthesis. European Spine Journal. 2025 Jun 2. doi: 10.1007/s00586-025-08959-x. PMID: 40455236. （共同通讯作者,IF=2.7/Q1）
Zehua Su, Jiaqi Lin, Xuejiao Zeng, Xin Li, Qianhao Hou, Qing Wang, Chunzheng Liu, Jiawen Qin, Yuling Li, Jinyuan Zhang, Xiangrui Wang, Shuwen Qian, Lijun Liao. Ozone water enema activates SIRT1-Nrf2/HO-1 pathway to ameliorate gut dysbiosis in mice receiving COVID-19 patient-derived faecal microbiota. J Med Microbiol. 2025 Sep;74(9):002038. doi: 10.1099/jmm.0.002038. (通讯作者，IF 2.4/Q3)
Xiaomei Wang, Yinsheng Chen, Shuwen Qian, Jia Kong, Zehua Su, Qingxiu Wang, Lijun Liao. Compound Probiotics Improve Neuropathic Pain Prognosis in a Murine Model of Chronic Constriction Injury. Journal of Pain Research. 2024 Dec 11;17:4213-4221. doi: 10.2147/JPR.S486259. （通讯作者, IF=2.5/Q2）.
Weizhi He, Kai Jiang, Hua Qiu, Lijun Liao#, Shasha Wang. 16-membered ring macrolides and erythromycin induce ermB expression by different mechanisms. BMC Microbiology. 2022 Jun 9; 22(1):152. doi.org/10.1186/s12866-022-02565-3（#共同通讯作者，IF 4.2/Q1）
Junyi Duan, Xin Chen, Yixing Wang, Gang Zhao, Jing Li, Yi Gao, Jinyuan Zhang, Xiangrui Wang, Lijun Liao#, Yuelai Chen. Acupoint catgut embedding as adjunctive therapy for patients with gallstones. Journal of Clinical Gastroenterology. 2022 Jan 1; 56(1): e77-e83. doi:10.1097/MCG.0000000000001487. (#共同通讯作者，IF 2.7/Q2)
Mick Frissen, Lijun Liao, Kai Schneider, Sonja Djudjaj, Philip Puchas, Johannes Haybaeck, Alexander Wree, Ulrike Rolle-Kampczyk, Martin von Bergen, Eicke Latz, Peter Boor and Christian Trautwein. Bidirectional role of NLRP3 during acute and chronic cholestatic liver injury. Hepatology. 2021 May;73(5):1836-1854. doi: 10.1002/hep.31494（IF 15.7/Q1）
Zehua Su, Jiaqi Lin, Xuejiao Zeng, Xin Li, Qianhao Hou, Qing Wang, Chunzheng Liu, Jiawen Qin, Yuling Li, Jinyuan Zhang, Xiangrui Wang, Shuwen Qian, Lijun Liao. Ozone water enema activates SIRT1-Nrf2/HO-1 pathway to ameliorate gut dysbiosis in mice receiving COVID-19 patient-derived faecal microbiota. J Med Microbiol. 2025 Sep;74(9):002038. doi: 10.1099/jmm.0.002038. PMID: 40960868; PMCID: PMC12444790 (IF 2.0/Q3)
Wenfang Gui, Mikal Jacob Hole, Antonio Molinaro, Karolina Edlund, Kristin K. Jørgensen, Huan Su, Brigitte Begher-Tibbe, Nikolaus Gaßler, Carolin V. Schneider, Uthayakumar Muthukumarasamy, Antje Mohs, Lijun Liao, Julius Jaeger, Christian J. Mertens, Ina Bergheim, Till Strowig, Jan G. Hengstler, Johannes R. Hov, Hanns-Ulrich Marschall, Christian Trautwein & Kai Markus Schneider. Colitis ameliorates cholestatic liver disease via suppression of bile acid synthesis. Nat Commun. 2023 Jun 6;14(1):3304. doi: 10.1038/s41467-023-38840-8. （IF 17.674/Q1）
Huan Su, Madhuri Haque, Svea Becker, Karolina Edlund, Julia Duda, Qingbi Wang, Johanna Reißing, Hanns-Ulrich Marschall, Lena S. Candels, Mohamed Mohamed, Wilhelm Sjöland, Lijun Liao, Till Strowig, Jörg Rahnenführer, Jan G. Hengstler, Christian Trautwein. Long-term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals. Liver International. 2023 Aug;43(8):1699-1713. doi: 10.1111/liv.15587（IF 8.754/Q1）
Kai Markus Schneider, Carsten Elfers, Ahmed Ghallab, Carolin Victoria Schneider, Eric J C Galvez, Antje Mohs, Wenfang Gui, Lena Susanna, Theresa Hildegard Wirtz, Sebbastian Zuehlke, Michael Spiteller, Maiju Myllys, Alain Route, Amirouche Ouzerdine, Benjamin Lelouvier, Konrad Kilic, Lijun Liao, Anika Nier, Eicke Latz, Ina Bergheim, Christoph A Thaiss, Jan G Hengstler, Till Strowig, Christian Trautwein. Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury. Cellular and Molecular Gastroenterology and Hepatology. 2021;11(4):909-933. doi: 10.1016/j.jcmgh.2020.11.002. （IF 9.225/Q1）
Wencheng Zhang, Yangyang Cui, Mengqi Lu, Mingyang Xu, Yuting Li, Haimeng Song, Yi Luo, Jinjia Song, Yong Yang, Xicheng Wang, Lijun Liao, Yunfang Wang, Lola Reid, Zhiying He. Hormonally and chemically defined expansion conditions for organoids of biliary tree Stem Cells. Bioact Mater. 2024 Sep 10;41:672-695. doi: 10.1016/j.bioactmat.2024.08.010. PMID: 39309110（IF 18/Q1）
Kai Markus Schneider, Lena Susanna Candels, Johannes R Hov, Maiju Myllys, Reham Hassan, Carolin Victoria Schneider, Annika Wahlström, Antje Mohs, Sebastian Zühlke, Lijun Liao, Carsten Elfers, Konrad Kilic, Marcus Henricsson, Antonio Molinaro, Maximilian Hatting, Ayham Zaza, Dirk Drasdo, Mick Frissen, A Sloan Devlin, Eric J C Gálvez, Till Strowig, Tom H Karlsen, Jan G Hengstler, Hanns-Ulrich Marschall, Ahmed Ghallab, Christian Trautwein. Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling. Nature Metabolism. 2021 Sep;3(9):1228-1241. doi: 10.1038/s42255-021-00452-1. (IF 19.86/Q1)
Kai Markus Schneider, Veerle Bieghs, Felix Heymann, Wei Hu, Daniela Dreymueller, Lijun Liao, Mick Frissen, Andreas Ludwig, Nikolaus Gassler, Oliver Pabst, Eicke Latz, Gernot Sellge, John Penders, Frank Tacke, Christian Trautwein. CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis. Hepatology. 2015, 62(5):1405–1416. doi: 10.1002/hep.27982.（IF 17.425/Q1）
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侯千暠，胡静怡，黄钻元，张金源，曾雪骄，李鑫，林佳琪，李语玲，廖丽君.青春双歧杆菌对溃疡性结肠炎小鼠的缓解作用.微生物学报,1-17[2024-09-29].https://doi.org/10.13343/j.cnki.wsxb.20240402.
师浩兵, 侯千暠, 廖丽君#. 肠-肝轴紊乱与脓毒症关系的研究进展. 中华危重病急救医学，2022,34(07):769-772.
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